GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
LEGPH:DRRA
Contents
| Species (Taxon ID) | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 / DSM 7513). (272624) | |
| Gene Name(s) | drrA (synonyms: sidM) | |
| Protein Name(s) | Multifunctional virulence effector protein DrrA
Defects in Rab1 recruitment protein A Adenosine monophosphate-protein transferase AMPylator Guanosine monophosphate-protein transferase GMPylator Rab1 guanine nucleotide exchange factor | |
| External Links | ||
| UniProt | Q5ZSQ3 | |
| EMBL | DQ845395 AE017354 | |
| RefSeq | WP_010948166.1 YP_096471.1 | |
| PDB | 2WWX 3JZ9 3JZA 3L0I 3L0M 3N6O 4MXP | |
| PDBsum | 2WWX 3JZ9 3JZA 3L0I 3L0M 3N6O 4MXP | |
| IntAct | Q5ZSQ3 | |
| MINT | MINT-7720716 | |
| STRING | 272624.lpg2464 | |
| EnsemblBacteria | AAU28524 | |
| GeneID | 19834029 | |
| KEGG | lpn:lpg2464 | |
| PATRIC | 22332221 | |
| eggNOG | NOG12793 | |
| HOGENOM | HOG000126893 | |
| KO | K15480 | |
| OMA | IRENEGN | |
| OrthoDB | EOG6X6R8N | |
| BioCyc | LPNE272624:GHDI-2463-MONOMER | |
| Proteomes | UP000000609 | |
| GO | GO:0044161 GO:0044162 GO:0016020 GO:0005524 GO:0005085 GO:0070273 GO:0070733 GO:0044600 GO:0017137 GO:0009405 GO:0043547 GO:0018117 GO:0018260 GO:0006612 GO:0032313 | |
| InterPro | IPR028057 | |
| Pfam | PF14860 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006612 |
protein targeting to membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P62820) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070733 |
protein adenylyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044600 |
protein guanylyltransferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043087 |
regulation of GTPase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018260 |
protein guanylylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018117 |
protein adenylylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017137 |
Rab GTPase binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005623 |
cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0006612 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017137 |
Rab GTPase binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043087 |
regulation of GTPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044161 |
host cell cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044162 |
host cell cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Blümer, J et al. (2013) RabGEFs are a major determinant for specific Rab membrane targeting. J. Cell Biol. 200 287-300 PubMed GONUTS page
- ↑ Mukherjee, S et al. (2011) Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature 477 103-6 PubMed GONUTS page
- ↑ Schoebel, S et al. (2010) High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep. 11 598-604 PubMed GONUTS page
b
h
l
p
