MOUSE:ITSN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Itsn1 (synonyms: Ese1, Itsn)
Protein Name(s)	Intersectin-1 EH and SH3 domains protein 1
External Links
UniProt	Q9Z0R4
EMBL	AF132481 AF132478 AC126053 AC131691 AC134837 AF169621 AF356517
CCDS	CCDS37402.1 CCDS49913.1
RefSeq	NP_001103745.1 NP_034717.2
UniGene	Mm.40546
PDB	3HS8 3JV3
PDBsum	3HS8 3JV3
ProteinModelPortal	Q9Z0R4
SMR	Q9Z0R4
BioGrid	200851
IntAct	Q9Z0R4
MINT	MINT-86500
STRING	10090.ENSMUSP00000066361
PhosphoSite	Q9Z0R4
MaxQB	Q9Z0R4
PaxDb	Q9Z0R4
PRIDE	Q9Z0R4
Ensembl	ENSMUST00000056482 ENSMUST00000114002
GeneID	16443
KEGG	mmu:16443
CTD	6453
MGI	MGI:1338069
eggNOG	COG5422
GeneTree	ENSGT00760000118985
HOGENOM	HOG000010175
HOVERGEN	HBG052159
InParanoid	Q9Z0R4
TreeFam	TF324293
Reactome	REACT_204733 REACT_209641 REACT_210090 REACT_257656
ChiTaRS	Itsn1
EvolutionaryTrace	Q9Z0R4
NextBio	289695
PRO	PR:Q9Z0R4
Proteomes	UP000000589
CleanEx	MM_ITSN1
ExpressionAtlas	Q9Z0R4
Genevestigator	Q9Z0R4
GO	GO:0030054 GO:0005905 GO:0030139 GO:0030027 GO:0043005 GO:0005886 GO:0045202 GO:0005509 GO:0019209 GO:0005089 GO:0006897 GO:0043524 GO:0042327 GO:0051897 GO:0007264
Gene3D	1.10.238.10 1.20.900.10 2.30.29.30 2.60.40.150
InterPro	IPR000008 IPR000219 IPR011992 IPR018247 IPR002048 IPR000261 IPR001331 IPR001849 IPR011993 IPR001452
Pfam	PF00168 PF00621 PF00018 PF14604
PRINTS	PR00452
SMART	SM00239 SM00054 SM00027 SM00233 SM00325 SM00326
SUPFAM	SSF48065 SSF49562 SSF50044
PROSITE	PS50004 PS00741 PS50010 PS00018 PS50222 PS50031 PS50003 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043524	negative regulation of neuron apoptotic process	PMID:23054079^[1]	ECO:0000314			P		Fg1 Inhibition of Intersectin-1 causes apoptotic endothelial cell death. Fg2 acute inhibition of expression causes lung micro vessel loss. Fg3 Intersectin-1 inhibitor induces lung injury. Fg4 Chronic inhibition causes significant endothelial cell death	complete CACAO 7422
part_of	GO:0098833	presynaptic endocytic zone	PMID:23633571^[2]	ECO:0006004	super-resolution microscopy evidence used in manual assertion		C	part_of:(GO:0044305) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098833	presynaptic endocytic zone	PMID:23633571^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0044305) part_of:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:18676989^[3]	ECO:0006039	genetically encoded fluorescent electrophysiology assay evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:18676989^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:23633571^[2]	ECO:0006004	super-resolution microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:23633571^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001288	positive regulation of caveolin-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
part_of	GO:0098871	postsynaptic actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
part_of	GO:0097708	intracellular vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:17875942^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:17875942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:17875942^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:11744688^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019209	kinase activator activity	PMID:17875942^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007264	small GTPase mediated signal transduction	PMID:11744688^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
colocalizes_with	GO:0005905	clathrin-coated pit	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2935	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q15811	C		Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019209	P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15811 ensembl:ENSP00000370719	F		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15811 ensembl:ENSP00000370719	F		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15811 ensembl:ENSP00000370719	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15811 ensembl:ENSP00000370719	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15811 ensembl:ENSP00000370719	C		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
involved_in	GO:2001288	positive regulation of caveolin-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	P		Seeded From UniProt	complete
involved_in	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
part_of	GO:0098871	postsynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
part_of	GO:0097708	intracellular vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVE9 ensembl:ENSRNOP00000044773	C		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15811-2	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q15811-2	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-3928643 Reactome:R-MMU-3928626 Reactome:R-MMU-3928605	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0268	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bardita, C et al. (2013) In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis 18 57-76 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Sakaba, T et al. (2013) Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc. Natl. Acad. Sci. U.S.A. 110 8266-71 PubMed GONUTS page
↑ ^3.0 ^3.1 Yu, Y et al. (2008) Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. Hum. Mol. Genet. 17 3281-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Das, M et al. (2007) Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol. Cell. Biol. 27 7906-17 PubMed GONUTS page
↑ ^5.0 ^5.1 Jenna, S et al. (2002) The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. J. Biol. Chem. 277 6366-73 PubMed GONUTS page

[PMID:23054079-1] Bardita, C et al. (2013) In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis 18 57-76 PubMed GONUTS page

[PMID:23633571-2] 2.0 ^2.1 ^2.2 ^2.3 Sakaba, T et al. (2013) Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc. Natl. Acad. Sci. U.S.A. 110 8266-71 PubMed GONUTS page

[PMID:18676989-3] 3.0 ^3.1 Yu, Y et al. (2008) Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities. Hum. Mol. Genet. 17 3281-90 PubMed GONUTS page

[PMID:17875942-4] 4.0 ^4.1 ^4.2 ^4.3 Das, M et al. (2007) Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol. Cell. Biol. 27 7906-17 PubMed GONUTS page

[PMID:11744688-5] 5.0 ^5.1 Jenna, S et al. (2002) The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. J. Biol. Chem. 277 6366-73 PubMed GONUTS page

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MOUSE:ITSN1

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