MOUSE:PREX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prex2 (synonyms: Depdc2)
Protein Name(s)	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein P-Rex2 PtdIns(3,4,5)-dependent Rac exchanger 2 DEP domain-containing protein 2
External Links
UniProt	Q3LAC4
EMBL	AM109952 AC102481 AC102529 AC102631 AC164600 AK018093 AK138884 AK142414
CCDS	CCDS48217.1
RefSeq	NP_083801.1
UniGene	Mm.123247
ProteinModelPortal	Q3LAC4
PhosphoSite	Q3LAC4
MaxQB	Q3LAC4
PaxDb	Q3LAC4
PRIDE	Q3LAC4
Ensembl	ENSMUST00000027056
GeneID	109294
KEGG	mmu:109294
UCSC	uc007ahs.2 uc007aht.1
CTD	80243
MGI	MGI:1923385
eggNOG	COG5422
GeneTree	ENSGT00760000118925
HOGENOM	HOG000115690
HOVERGEN	HBG053677
InParanoid	Q3LAC4
OMA	ESMEGYY
OrthoDB	EOG7V49XH
TreeFam	TF328639
NextBio	361887
PRO	PR:Q3LAC4
Proteomes	UP000000589
Bgee	Q3LAC4
ExpressionAtlas	Q3LAC4
Genevestigator	Q3LAC4
GO	GO:0005886 GO:0030675 GO:0030676 GO:0008344 GO:0048813 GO:0007186 GO:0014065
Gene3D	1.10.10.10 1.20.900.10 2.30.29.30 2.30.42.10
InterPro	IPR000591 IPR000219 IPR001331 IPR001478 IPR001849 IPR011993 IPR011991
Pfam	PF00610 PF00595 PF00621
SMART	SM00049 SM00228 SM00233 SM00325
SUPFAM	SSF48065 SSF50156
PROSITE	PS50186 PS00741 PS50010 PS50106 PS50003

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0030676	Rac guanyl-nucleotide exchange factor activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001107229 UniProtKB:Q70Z35	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3040696 PANTHER:PTN001107229 UniProtKB:Q70Z35	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1923385 PANTHER:PTN001107229 RGD:1306534	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:18334636	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3783295	P	occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0030676	Rac guanyl-nucleotide exchange factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q70Z35	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014065	phosphatidylinositol 3-kinase signaling		ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3856561	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:18334636	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3783295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q70Z35	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane		ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q70Z35	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
enables	GO:0030676	Rac guanyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q70Z35 ensembl:ENSP00000288368	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q70Z35 ensembl:ENSP00000288368	P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q70Z35 ensembl:ENSP00000288368	F		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
enables	GO:0030676	Rac guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037367	F		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000591 InterPro:IPR001331	P		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F		Seeded From UniProt	complete
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References

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