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MOUSE:ARHG6

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Arhgef6
Protein Name(s) Rho guanine nucleotide exchange factor 6

Alpha-PIX Rac/Cdc42 guanine nucleotide exchange factor 6

External Links
UniProt Q8K4I3
EMBL AF393831
AK040468
RefSeq NP_690014.2
UniGene Mm.261443
PDB 1V61
PDBsum 1V61
ProteinModelPortal Q8K4I3
SMR Q8K4I3
BioGrid 215941
IntAct Q8K4I3
MINT MINT-4117855
PhosphoSite Q8K4I3
MaxQB Q8K4I3
PaxDb Q8K4I3
PRIDE Q8K4I3
DNASU 73341
GeneID 73341
KEGG mmu:73341
UCSC uc009thd.2
CTD 9459
MGI MGI:1920591
eggNOG NOG314429
HOGENOM HOG000231381
HOVERGEN HBG050569
InParanoid Q8K4I3
KO K05729
PhylomeDB Q8K4I3
Reactome REACT_204733
REACT_209641
REACT_210090
REACT_255191
EvolutionaryTrace Q8K4I3
NextBio 338019
PRO PR:Q8K4I3
Proteomes UP000000589
Bgee Q8K4I3
ExpressionAtlas Q8K4I3
Genevestigator Q8K4I3
GO GO:0005911
GO:0030027
GO:0005089
GO:0035556
GO:0030032
Gene3D 1.10.418.10
1.20.900.10
2.30.29.30
InterPro IPR001715
IPR000219
IPR001331
IPR001849
IPR011993
IPR001452
IPR003096
Pfam PF00307
PF00169
PF00621
PF14604
PRINTS PR00452
PR00888
SMART SM00033
SM00233
SM00325
SM00326
SUPFAM SSF47576
SSF48065
SSF50044
PROSITE PS50021
PS00741
PS50010
PS50003
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030032

lamellipodium assembly

PMID:18325335[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

PMID:18325335[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:23793062[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001331

F

Seeded From UniProt

complete

enables

GO:0005089

Rho guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

F

Seeded From UniProt

complete

involved_in

GO:0035023

regulation of Rho protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001331

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0344

F

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0291

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Matsuda, C et al. (2008) Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett. 582 1189-96 PubMed GONUTS page
  2. Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page