HUMAN:ARHGG

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ARHGEF16 (synonyms: EPHEXIN4, NBR)
Protein Name(s)	Rho guanine nucleotide exchange factor 16 Ephexin-4
External Links
UniProt	Q5VV41
EMBL	D89016 BT007270 AL512413 AL512413 BC002681 BC051838
CCDS	CCDS46.2
RefSeq	NP_055263.2 XP_006710641.1
UniGene	Hs.87435
PDB	1X6B
PDBsum	1X6B
ProteinModelPortal	Q5VV41
SMR	Q5VV41
BioGrid	118085
IntAct	Q5VV41
MINT	MINT-3295714
STRING	9606.ENSP00000367629
PhosphoSite	Q5VV41
DMDM	74747198
MaxQB	Q5VV41
PaxDb	Q5VV41
PRIDE	Q5VV41
DNASU	27237
Ensembl	ENST00000378371 ENST00000378373 ENST00000378378
GeneID	27237
KEGG	hsa:27237
UCSC	uc001akg.4
CTD	27237
GeneCards	GC01P003370
HGNC	HGNC:15515
HPA	HPA010609
neXtProt	NX_Q5VV41
PharmGKB	PA24971
eggNOG	COG5422
GeneTree	ENSGT00550000074493
HOGENOM	HOG000007536
HOVERGEN	HBG059167
InParanoid	Q5VV41
OMA	QTEHHHL
OrthoDB	EOG73NG2P
PhylomeDB	Q5VV41
TreeFam	TF316357
Reactome	REACT_11051 REACT_13638 REACT_18407
ChiTaRS	ARHGEF16
EvolutionaryTrace	Q5VV41
GenomeRNAi	27237
NextBio	50111
PRO	PR:Q5VV41
Proteomes	UP000005640
Bgee	Q5VV41
CleanEx	HS_ARHGEF16
ExpressionAtlas	Q5VV41
Genevestigator	Q5VV41
GO	GO:0005829 GO:0030165 GO:0030971 GO:0017048 GO:0005089 GO:0032864 GO:0032863 GO:0097190 GO:0060326 GO:0048011 GO:0043065 GO:0090004 GO:0051056 GO:0007264
Gene3D	1.20.900.10 2.30.29.30
InterPro	IPR000219 IPR001849 IPR011993 IPR001452
Pfam	PF00169 PF00621 PF14604
SMART	SM00233 SM00325 SM00326
SUPFAM	SSF48065 SSF50044
PROSITE	PS50010 PS50003 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0017147	Wnt-protein binding	PMID:21139582	ECO:0000021		UniProtKB:O14907 UniProtKB:Q5VV41	F		The introduction of this paper states that Tip-I has been shown to be a protein involved in the wnt(Reynaud et al,2000; Kanamori et al,2003) Experimental evidence in this paper show the interaction od TipI and GEF 16. Figure 1 Interactions, regulation and stability of GEF16. (A) Yeast mating assay confirming that Tip-1 binds to short carboxyl terminal GEF16 fragments isolated from the primary Tip-1 yeast two-hybrid screen. (B) Glutathione transferase pull-down of Tip-1 with IVTT full-length wildtype and mutant GEF16 (wtGEF16/mutGEF16). The wtGEF16 contains the PDZ-binding domain ETDV, whereas mutGEF16 has the TDV residues deleted. Tip-1-GST fusion protein and GST control protein were bound to glutathione-sepharose beads. These were mixed with equal amounts of the IVTT wtGEF16 or mutGEF16 proteins, and then washed with binding buffer. Bound proteins were separated by SDS–PAGE and visualised by western immunoblotting with anti-GEF16. The GST-Tip-1 protein bound to the wtGEF16, but did not bind to the mutant form, whereas the GST control did not bind either product.	complete
	GO:0043088		PMID:21139582	ECO:0000314					Fluorescent kinetic analysis of Cdc42 activation by GEF16 in the presence of high-risk HPV16 E6 and Tip-1. Different combinations of 2 mM concentrations of the recombinant proteins GEF16, Tip-1 and HPV16 E6 were added after 4 min of initial readings being taken with Cdc42 and assay buffers alone. Each combination was carried out in triplicate. It can be seen that Cdc42 activation by GEF16 is enhanced in the presence of Tip-1 and E6. HPV16 E6, Tip-1, ARHGEF16 and Cdc42 activation.	complete
enables	GO:0045296	cadherin binding	PMID:25468996	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	PMID:21139582	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:21139582	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14907	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:20679435	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:20679435	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	PMID:20679435	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:20679435	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29317	F		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	PMID:20679435	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	PMID:20679435	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84095	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	PMID:20679435	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	P		Seeded From UniProt	complete
involved_in	GO:0051056	regulation of small GTPase mediated signal transduction	Reactome:R-HSA-194840	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-193648	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-419166 Reactome:R-HSA-205039 Reactome:R-HSA-194913	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F		Seeded From UniProt	complete
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References

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