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DICDI:GBPC
Contents
| Species (Taxon ID) | Dictyostelium discoideum (Slime mold). (44689) | |
| Gene Name(s) | gbpC (synonyms: gefT, rasGEFT) | |
| Protein Name(s) | Cyclic GMP-binding protein C
Ras guanine nucleotide exchange factor T RasGEF domain-containing protein T | |
| External Links | ||
| UniProt | Q8MVR1 | |
| EMBL | AF481923 AAFI02000175 | |
| RefSeq | XP_635392.1 | |
| ProteinModelPortal | Q8MVR1 | |
| STRING | 44689.DDB0191359 | |
| PaxDb | Q8MVR1 | |
| EnsemblProtists | DDB0191359 | |
| GeneID | 8627976 | |
| KEGG | ddi:DDB_G0291079 | |
| dictyBase | DDB_G0291079 | |
| eggNOG | KOG0192 COG0515 COG1100 | |
| InParanoid | Q8MVR1 | |
| OMA | EENAINT | |
| PRO | PR:Q8MVR1 | |
| Proteomes | UP000002195 UP000002195 | |
| GO | GO:0005737 GO:0005524 GO:0030553 GO:0005525 GO:0005543 GO:0004674 GO:0005088 GO:0031589 GO:0019934 GO:0007163 GO:0051272 GO:0043547 GO:0045860 GO:0046579 GO:0050920 GO:0007264 | |
| Gene3D | 1.10.10.10 1.10.840.10 2.60.120.10 3.40.50.300 3.80.10.10 | |
| InterPro | IPR018490 IPR000595 IPR032171 IPR000591 IPR004182 IPR011009 IPR032675 IPR001611 IPR013684 IPR027417 IPR000719 IPR017441 IPR000651 IPR023578 IPR001895 IPR014710 IPR020859 IPR001245 IPR008271 IPR011991 | |
| Pfam | PF00027 PF16095 PF00610 PF02893 PF07714 PF00617 PF00618 PF08477 | |
| PRINTS | PR00109 | |
| SMART | SM00100 SM00568 SM00147 | |
| SUPFAM | SSF46785 SSF48366 SSF51206 SSF52058 SSF52540 SSF56112 | |
| PROSITE | PS50042 PS50186 PS51450 PS00107 PS50011 PS00108 PS50009 PS50212 PS51424 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0031252 |
cell leading edge |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(GO:0051602) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051602 |
response to electrical stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050920 |
regulation of chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050920 |
regulation of chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046579 |
positive regulation of Ras protein signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045860 |
positive regulation of protein kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031589 |
cell-substrate adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030553 |
cGMP binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030553 |
cGMP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019934 |
cGMP-mediated signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007163 |
establishment or maintenance of cell polarity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005886 |
plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005088 |
Ras guanyl-nucleotide exchange factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030553 |
cGMP binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007264 |
small GTPase mediated signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051272 |
positive regulation of cellular component movement |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030553 |
cGMP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sato, MJ et al. (2009) Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc. Natl. Acad. Sci. U.S.A. 106 6667-72 PubMed GONUTS page
- ↑ 2.0 2.1 Ragaz, C et al. (2008) The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell. Microbiol. 10 2416-33 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Bosgraaf, L et al. (2005) RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. J. Cell. Sci. 118 1899-910 PubMed GONUTS page
- ↑ 4.0 4.1 van Egmond, WN et al. (2008) Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. J. Biol. Chem. 283 30412-20 PubMed GONUTS page
- ↑ Goldberg, JM et al. (2006) Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways. FEBS Lett. 580 2059-64 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Kortholt, A et al. (2012) Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. J. Biol. Chem. 287 2749-58 PubMed GONUTS page
- ↑ Goldberg, JM et al. (2002) Identification of four candidate cGMP targets in Dictyostelium. Proc. Natl. Acad. Sci. U.S.A. 99 6749-54 PubMed GONUTS page
- ↑ Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page
c
p
- GO:0005543 ! phospholipid binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0045860 ! positive regulation of protein kinase activity
- GO:0046579 ! positive regulation of Ras protein signal transduction
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
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