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DICDI:GBPC

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) gbpC (synonyms: gefT, rasGEFT)
Protein Name(s) Cyclic GMP-binding protein C

Ras guanine nucleotide exchange factor T RasGEF domain-containing protein T

External Links
UniProt Q8MVR1
EMBL AF481923
AAFI02000175
RefSeq XP_635392.1
ProteinModelPortal Q8MVR1
STRING 44689.DDB0191359
PaxDb Q8MVR1
EnsemblProtists DDB0191359
GeneID 8627976
KEGG ddi:DDB_G0291079
dictyBase DDB_G0291079
eggNOG KOG0192
COG0515
COG1100
InParanoid Q8MVR1
OMA EENAINT
PRO PR:Q8MVR1
Proteomes UP000002195
UP000002195
GO GO:0005737
GO:0005524
GO:0030553
GO:0005525
GO:0005543
GO:0004674
GO:0005088
GO:0031589
GO:0019934
GO:0007163
GO:0051272
GO:0043547
GO:0045860
GO:0046579
GO:0050920
GO:0007264
Gene3D 1.10.10.10
1.10.840.10
2.60.120.10
3.40.50.300
3.80.10.10
InterPro IPR018490
IPR000595
IPR032171
IPR000591
IPR004182
IPR011009
IPR032675
IPR001611
IPR013684
IPR027417
IPR000719
IPR017441
IPR000651
IPR023578
IPR001895
IPR014710
IPR020859
IPR001245
IPR008271
IPR011991
Pfam PF00027
PF16095
PF00610
PF02893
PF07714
PF00617
PF00618
PF08477
PRINTS PR00109
SMART SM00100
SM00568
SM00147
SUPFAM SSF46785
SSF48366
SSF51206
SSF52058
SSF52540
SSF56112
PROSITE PS50042
PS50186
PS51450
PS00107
PS50011
PS00108
PS50009
PS50212
PS51424

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0031252

cell leading edge

PMID:19346484[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(GO:0051602)

Seeded From UniProt

complete

involved_in

GO:0051602

response to electrical stimulus

PMID:19346484[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050920

regulation of chemotaxis

PMID:18673369[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050920

regulation of chemotaxis

PMID:15827084[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046579

positive regulation of Ras protein signal transduction

PMID:18703517[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045860

positive regulation of protein kinase activity

PMID:16546177[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031589

cell-substrate adhesion

PMID:15827084[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:15827084[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:18673369[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019934

cGMP-mediated signaling

PMID:22119747[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007163

establishment or maintenance of cell polarity

PMID:15827084[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005938

cell cortex

PMID:22119747[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

PMID:22119747[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22119747[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

PMID:22119747[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:22119747[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005088

Ras guanyl-nucleotide exchange factor activity

PMID:18703517[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

PMID:12011437[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001895
InterPro:IPR036964

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0007264

small GTPase mediated signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001895
InterPro:IPR036964

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000591

P

Seeded From UniProt

complete

involved_in

GO:0051272

positive regulation of cellular component movement

PMID:15473840[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0344

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0030553

cGMP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0142

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Sato, MJ et al. (2009) Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc. Natl. Acad. Sci. U.S.A. 106 6667-72 PubMed GONUTS page
  2. 2.0 2.1 Ragaz, C et al. (2008) The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell. Microbiol. 10 2416-33 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Bosgraaf, L et al. (2005) RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. J. Cell. Sci. 118 1899-910 PubMed GONUTS page
  4. 4.0 4.1 van Egmond, WN et al. (2008) Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. J. Biol. Chem. 283 30412-20 PubMed GONUTS page
  5. Goldberg, JM et al. (2006) Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways. FEBS Lett. 580 2059-64 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Kortholt, A et al. (2012) Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. J. Biol. Chem. 287 2749-58 PubMed GONUTS page
  7. Goldberg, JM et al. (2002) Identification of four candidate cGMP targets in Dictyostelium. Proc. Natl. Acad. Sci. U.S.A. 99 6749-54 PubMed GONUTS page
  8. Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page