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HUMAN:BIG1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ARFGEF1 (synonyms: ARFGEP1, BIG1) | |
| Protein Name(s) | Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Brefeldin A-inhibited GEP 1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 p200 ARF guanine nucleotide exchange factor p200 ARF-GEP1 | |
| External Links | ||
| UniProt | Q9Y6D6 | |
| EMBL | AF084520 AF111162 AK001788 AL117446 | |
| CCDS | CCDS6199.1 | |
| PIR | T17241 | |
| RefSeq | NP_006412.2 XP_005251191.1 | |
| UniGene | Hs.656902 | |
| PDB | 3LTL | |
| PDBsum | 3LTL | |
| ProteinModelPortal | Q9Y6D6 | |
| SMR | Q9Y6D6 | |
| BioGrid | 115816 | |
| DIP | DIP-29748N | |
| IntAct | Q9Y6D6 | |
| MINT | MINT-1728435 | |
| STRING | 9606.ENSP00000262215 | |
| PhosphoSite | Q9Y6D6 | |
| DMDM | 116241267 | |
| MaxQB | Q9Y6D6 | |
| PaxDb | Q9Y6D6 | |
| PeptideAtlas | Q9Y6D6 | |
| PRIDE | Q9Y6D6 | |
| Ensembl | ENST00000262215 | |
| GeneID | 10565 | |
| KEGG | hsa:10565 | |
| UCSC | uc003xxo.2 | |
| CTD | 10565 | |
| GeneCards | GC08M068085 | |
| HGNC | HGNC:15772 | |
| HPA | HPA023399 HPA023822 | |
| MIM | 604141 | |
| neXtProt | NX_Q9Y6D6 | |
| PharmGKB | PA134908197 | |
| eggNOG | COG5307 | |
| GeneTree | ENSGT00760000119036 | |
| HOGENOM | HOG000181045 | |
| HOVERGEN | HBG004846 | |
| InParanoid | Q9Y6D6 | |
| KO | K18442 | |
| OMA | ICECFEN | |
| PhylomeDB | Q9Y6D6 | |
| TreeFam | TF300714 | |
| ChiTaRS | ARFGEF1 | |
| EvolutionaryTrace | Q9Y6D6 | |
| GeneWiki | ARFGEF1 | |
| GenomeRNAi | 10565 | |
| NextBio | 40097 | |
| PRO | PR:Q9Y6D6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y6D6 | |
| CleanEx | HS_ARFGEF1 | |
| ExpressionAtlas | Q9Y6D6 | |
| Genevestigator | Q9Y6D6 | |
| GO | GO:0005737 GO:0005829 GO:0005794 GO:0000139 GO:0016363 GO:0005730 GO:0005634 GO:0048471 GO:0030532 GO:0005802 GO:0005086 GO:0005085 GO:0017022 GO:0034237 GO:0010256 GO:0006887 GO:0007030 GO:0030837 GO:0034259 GO:0043547 GO:0090284 GO:0090303 GO:0015031 GO:0032012 GO:2000114 GO:0016192 | |
| Gene3D | 1.10.1000.11 1.25.10.10 | |
| InterPro | IPR011989 IPR016024 IPR015403 IPR023394 IPR000904 | |
| Pfam | PF09324 PF01369 | |
| SMART | SM00222 | |
| SUPFAM | SSF48371 SSF48425 | |
| PROSITE | PS50190 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2000114 |
regulation of establishment of cell polarity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090303 |
positive regulation of wound healing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090284 |
positive regulation of protein glycosylation in Golgi |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034260 |
negative regulation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030837 |
negative regulation of actin filament polymerization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030532 |
small nuclear ribonucleoprotein complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017022 |
myosin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017022 |
myosin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010256 |
endomembrane system organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016192 |
vesicle-mediated transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000070561 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028538 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005086 |
ARF guanyl-nucleotide exchange factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028538 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A631 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A631 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A631 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005086 |
ARF guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032012 |
regulation of ARF protein signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006887 |
exocytosis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Li, CC et al. (2011) Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. Proc. Natl. Acad. Sci. U.S.A. 108 19228-33 PubMed GONUTS page
- ↑ 2.0 2.1 Shen, X et al. (2007) BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1. Proc. Natl. Acad. Sci. U.S.A. 104 1230-5 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Saeki, N et al. (2005) BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J. Biol. Chem. 280 10128-34 PubMed GONUTS page
- ↑ Li, H et al. (2003) Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). Proc. Natl. Acad. Sci. U.S.A. 100 1627-32 PubMed GONUTS page
- ↑ Padilla, PI et al. (2008) Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin. Proc. Natl. Acad. Sci. U.S.A. 105 3357-61 PubMed GONUTS page
- ↑ 6.0 6.1 Boal, F & Stephens, DJ (2010) Specific functions of BIG1 and BIG2 in endomembrane organization. PLoS ONE 5 e9898 PubMed GONUTS page
- ↑ 7.0 7.1 Yamaji, R et al. (2000) Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 97 2567-72 PubMed GONUTS page
- ↑ Padilla, PI et al. (2004) Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. Proc. Natl. Acad. Sci. U.S.A. 101 2752-7 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Togawa, A et al. (1999) Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J. Biol. Chem. 274 12308-15 PubMed GONUTS page
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- GO:0048471 ! perinuclear region of cytoplasm
- GO:0090303 ! positive regulation of wound healing
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0043547 ! positive regulation of GTPase activity
- Primates
- GO:0034237 ! protein kinase A regulatory subunit binding
- GO:0015031 ! protein transport
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