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PMID:20360857

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Citation

Boal, F and Stephens, DJ (2010) Specific functions of BIG1 and BIG2 in endomembrane organization. PLoS ONE 5:e9898

Abstract

Transport of molecules from one subcellular compartment to another involves the recruitment of cytosolic coat protein complexes to a donor membrane to concentrate cargo, deform the membrane and ultimately to form an independent carrier. Small-GTP-binding proteins of the Arf family are central to many membrane trafficking events. Arfs are activated by guanine nucleotide exchange factors (GEFs) which results in their recruitment to membranes and subsequent engagement with Arf-effectors, many of which are coat proteins. Among the human BFA-sensitive large Arf-GEFs, the function of the two closely related BIG1 and BIG2 is still not clear, and recent studies have raised the question of functional redundancy between the two proteins.

Links

PubMed PMC2845624 Online version:10.1371/journal.pone.0009898

Keywords

Bacterial Proteins/metabolism; Cloning, Molecular; Endosomes/metabolism; GTP-Binding Proteins/metabolism; Gene Expression Regulation; Golgi Apparatus/metabolism; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Guanine Nucleotide Exchange Factors/physiology; HeLa Cells; Humans; Intracellular Membranes/metabolism; Luminescent Proteins/metabolism; Protein Transport; RNA Interference; RNA, Small Interfering/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BIG2

involved_in

GO:0007032: endosome organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BIG2

involved_in

GO:0010256: endomembrane system organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BIG1

involved_in

GO:0010256: endomembrane system organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BIG1

involved_in

GO:0007030: Golgi organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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