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HUMAN:TRIO
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TRIO | |
| Protein Name(s) | Triple functional domain protein
PTPRF-interacting protein | |
| External Links | ||
| UniProt | O75962 | |
| EMBL | AK131423 AC010419 AC016549 AC016654 AC016656 AC026456 CH471102 CH471102 BC035585 BC017268 U42390 AF091395 AB209754 | |
| CCDS | CCDS3883.1 | |
| RefSeq | NP_009049.2 | |
| UniGene | Hs.130031 | |
| PDB | 1NTY 2NZ8 | |
| PDBsum | 1NTY 2NZ8 | |
| ProteinModelPortal | O75962 | |
| SMR | O75962 | |
| BioGrid | 113055 | |
| DIP | DIP-37578N | |
| IntAct | O75962 | |
| MINT | MINT-1397752 | |
| STRING | 9606.ENSP00000339299 | |
| PhosphoSite | O75962 | |
| MaxQB | O75962 | |
| PaxDb | O75962 | |
| PRIDE | O75962 | |
| Ensembl | ENST00000344135 ENST00000344204 | |
| GeneID | 7204 | |
| KEGG | hsa:7204 | |
| UCSC | uc003jff.3 uc003jfh.1 | |
| CTD | 7204 | |
| GeneCards | GC05P014143 | |
| HGNC | HGNC:12303 | |
| HPA | HPA008157 | |
| MIM | 601893 | |
| neXtProt | NX_O75962 | |
| PharmGKB | PA36982 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000119030 | |
| HOGENOM | HOG000044462 | |
| HOVERGEN | HBG108598 | |
| InParanoid | O75962 | |
| KO | K08810 | |
| OMA | IEERGRN | |
| OrthoDB | EOG7B8S3F | |
| PhylomeDB | O75962 | |
| TreeFam | TF318080 | |
| Reactome | REACT_11051 REACT_13638 REACT_18283 REACT_18407 REACT_22351 | |
| SignaLink | O75962 | |
| ChiTaRS | TRIO | |
| EvolutionaryTrace | O75962 | |
| GeneWiki | TRIO_(gene) | |
| GenomeRNAi | 7204 | |
| NextBio | 28234 | |
| PRO | PR:O75962 | |
| Proteomes | UP000005640 | |
| Bgee | O75962 | |
| CleanEx | HS_TRIO | |
| ExpressionAtlas | O75962 | |
| Genevestigator | O75962 | |
| GO | GO:0005829 GO:0005524 GO:0005085 GO:0004674 GO:0005089 GO:0097190 GO:0007411 GO:0048011 GO:0043065 GO:0043547 GO:0051056 GO:0007264 GO:0007185 | |
| Gene3D | 1.20.900.10 2.30.29.30 2.60.40.10 3.40.525.10 | |
| InterPro | IPR001251 IPR000219 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR001849 IPR011993 IPR000719 IPR002290 IPR008271 IPR001452 IPR018159 IPR002017 IPR028570 | |
| PANTHER | PTHR22826:SF104 | |
| Pfam | PF13716 PF07679 PF00069 PF00621 PF00018 PF00435 | |
| SMART | SM00408 SM00233 SM00325 SM00220 SM00516 SM00326 SM00150 | |
| SUPFAM | SSF48065 SSF50044 SSF52087 SSF56112 | |
| PROSITE | PS50191 PS50010 PS50835 PS50003 PS50011 PS00108 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045599 |
negative regulation of fat cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q0KL02 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035023 |
regulation of Rho protein signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007185 |
transmembrane receptor protein tyrosine phosphatase signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Reactome:R-HSA-194840 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
Reactome:R-HSA-193648 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-419166 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
Reactome:R-HSA-418856 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
enables |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Debant, A et al. (1996) The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. U.S.A. 93 5466-71 PubMed GONUTS page
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