RAT:BIG1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Arfgef1
Protein Name(s)	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 BIG1 Brefeldin A-inhibited GEP 1 ADP-ribosylation factor guanine nucleotide-exchange factor 1
External Links
UniProt	D4A631
EMBL	CH473984
RefSeq	NP_001263985.1 XP_008761719.1
UniGene	Rn.6834
ProteinModelPortal	D4A631
IntAct	D4A631
PRIDE	D4A631
Ensembl	ENSRNOT00000007766
GeneID	312915
KEGG	rno:312915
UCSC	RGD:1560793
CTD	10565
RGD	1560793
GeneTree	ENSGT00760000119036
InParanoid	D4A631
KO	K18442
OMA	ETQDQGM
OrthoDB	EOG7QVM1S
PhylomeDB	D4A631
TreeFam	TF300714
NextBio	665369
PRO	PR:D4A631
Proteomes	UP000002494
GO	GO:0005829 GO:0000139 GO:0016363 GO:0005730 GO:0048471 GO:0030532 GO:0005802 GO:0005086 GO:0034237 GO:0010256 GO:0007030 GO:0030837 GO:0034259 GO:0043547 GO:0090284 GO:0090303 GO:0015031 GO:0032012 GO:2000114 GO:0016192
Gene3D	1.10.1000.11 1.25.10.10
InterPro	IPR011989 IPR016024 IPR015403 IPR023394 IPR000904
Pfam	PF09324 PF01369
SMART	SM00222
SUPFAM	SSF48371 SSF48425
PROSITE	PS50190

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0031175	neuron projection development	PMID:24090963^[1]	ECO:0000315			P	As shown in Figure 3A and B, a knockdown in wild type BIG1 led to a significant reduction in the development of neurites, or neuron projections.	complete CACAO 9029
	GO:0051897	positive regulation of protein kinase B signaling cascade	PMID:24090963^[1]	ECO:0000315			P	As shown in Figure 5C, knockdowns of BIG1 lead to significantly reduced phosphorylation of AKT in the protein kinase B signalling pathway, as compared to the wild type.	complete CACAO 9030
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:24090963^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:24090963^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
involved_in	GO:0090284	positive regulation of protein glycosylation in Golgi	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
enables	GO:0034237	protein kinase A regulatory subunit binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	F	Seeded From UniProt	complete
involved_in	GO:0030837	negative regulation of actin filament polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
part_of	GO:0030532	small nuclear ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	C	Seeded From UniProt	complete
involved_in	GO:0010256	endomembrane system organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
involved_in	GO:0007030	Golgi organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:11809827^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6D6	C	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000070561 TAIR:locus:2025502 TAIR:locus:2084706	P	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028538 PANTHER:PTN000070561 RGD:1560793 RGD:631430 SGD:S000002577 TAIR:locus:2084706	C	Seeded From UniProt	complete
enables	GO:0005086	ARF guanyl-nucleotide exchange factor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028538 PANTHER:PTN000070561 SGD:S000002577 UniProtKB:Q9Y6D5	F	Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
involved_in	GO:0090284	positive regulation of protein glycosylation in Golgi	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
enables	GO:0034237	protein kinase A regulatory subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	F	Seeded From UniProt	complete
involved_in	GO:0030837	negative regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
part_of	GO:0030532	small nuclear ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	F	Seeded From UniProt	complete
involved_in	GO:0010256	endomembrane system organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
involved_in	GO:0007030	Golgi organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	F	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y6D6 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7X0 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7X0 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7X0 ensembl:ENSP00000262215	C	Seeded From UniProt	complete
enables	GO:0005086	ARF guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000904 InterPro:IPR035999	F	Seeded From UniProt	complete
involved_in	GO:0032012	regulation of ARF protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000904 InterPro:IPR035999	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F	Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0181	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhou, C et al. (2013) BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience 254 361-8 PubMed GONUTS page
↑ Zhao, X et al. (2002) Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Mol. Biol. Cell 13 119-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24090963-1] 1.0 ^1.1 ^1.2 ^1.3 Zhou, C et al. (2013) BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Neuroscience 254 361-8 PubMed GONUTS page

[PMID:11809827-2] Zhao, X et al. (2002) Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Mol. Biol. Cell 13 119-33 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:BIG1

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Annotations

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