MOUSE:BCR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bcr (synonyms: Kiaa3017)
Protein Name(s)	Breakpoint cluster region protein
External Links
UniProt	Q6PAJ1
EMBL	AC160402 BC002193 BC060270 X52831 AK129482
CCDS	CCDS35935.1
PIR	S14194
RefSeq	NP_001074881.1
UniGene	Mm.333722
ProteinModelPortal	Q6PAJ1
SMR	Q6PAJ1
BioGrid	225455
IntAct	Q6PAJ1
STRING	10090.ENSMUSP00000039247
PhosphoSite	Q6PAJ1
MaxQB	Q6PAJ1
PaxDb	Q6PAJ1
PRIDE	Q6PAJ1
Ensembl	ENSMUST00000164107
GeneID	110279
KEGG	mmu:110279
UCSC	uc007fqb.2
CTD	613
MGI	MGI:88141
eggNOG	NOG267747
GeneTree	ENSGT00760000119098
HOGENOM	HOG000006779
HOVERGEN	HBG004165
InParanoid	Q6PAJ1
KO	K08878
OMA	KRANSHS
OrthoDB	EOG7BP81P
TreeFam	TF105082
Reactome	REACT_196460 REACT_210090
ChiTaRS	Bcr
NextBio	363683
PRO	PR:Q6PAJ1
Proteomes	UP000000589
Bgee	Q6PAJ1
CleanEx	MM_BCR
ExpressionAtlas	Q6PAJ1
Genevestigator	Q6PAJ1
GO	GO:0005829 GO:0070062 GO:0005886 GO:0043234 GO:0005524 GO:0005096 GO:0004674 GO:0030675 GO:0005089 GO:0030036 GO:0007420 GO:0042472 GO:0035556 GO:0030336 GO:0050728 GO:0043314 GO:0050885 GO:0048008 GO:0043547 GO:0050766 GO:0032855 GO:0046777 GO:0051726 GO:0032496
Gene3D	1.10.555.10 1.20.900.10 2.30.29.30 2.60.40.150 4.10.280.30
InterPro	IPR015123 IPR000008 IPR000219 IPR001331 IPR001849 IPR011993 IPR008936 IPR000198
Pfam	PF09036 PF00168 PF00169 PF00620 PF00621
SMART	SM00239 SM00233 SM00324 SM00325
SUPFAM	SSF48065 SSF48350 SSF49562 SSF69036
PROSITE	PS50004 PS00741 PS50010 PS50003 PS50238

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060313	negative regulation of blood vessel remodeling	PMID:23152932^[1]	ECO:0000315			P		Figure 2A shows that the walls of the pulmonary arteries of the bcr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that bcr is one component needed for the prevention of artery remodeling	complete CACAO 6049
	GO:0043114	regulation of vascular permeability	PMID:23152932^[1]	ECO:0000315			P		"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Bcr...were clearly more severely affected." This suggests that bcr is a component needed for the prevention of vascular leakage under hypoxic conditions.	complete CACAO 6056
	GO:0002692	negative regulation of cellular extravasation	PMID:23152932^[1]	ECO:0000315			P		Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking... Bcr function as compared to wt mice," suggesting that bcr prevents leukocytes from pulmonary extravasation.	complete CACAO 6069
involved_in	GO:0002692	negative regulation of cellular extravasation	PMID:23152932^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043114	regulation of vascular permeability	PMID:23152932^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060313	negative regulation of blood vessel remodeling	PMID:23152932^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:25331951^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20962234^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:20962234^[3]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:20962234^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:20962234^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065002	intracellular protein transmembrane transport	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060268	negative regulation of respiratory burst	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060216	definitive hemopoiesis	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	PMID:11809706^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051171	regulation of nitrogen compound metabolic process	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:11921339^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050766	positive regulation of phagocytosis	PMID:17116687^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:19703997^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048872	homeostasis of number of cells	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043314	negative regulation of neutrophil degranulation	PMID:19703997^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P	regulates_o_occurs_in:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:11921339^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P	has_participant:(EMAPA:17290)\|has_participant:(EMAPA:17293)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23382219^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11274	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:19703997^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	PMID:17116687^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_results_in_movement_of:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:17116687^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P	occurs_in:(CL:0000581)\|occurs_in:(EMAPA:32760) occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:11684658^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17116687^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32760) part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17116687^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32760) part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307993	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:19703997^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107771	F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:17116687^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:97846)\|has_regulation_target:(MGI:MGI:2180784)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003014	renal system process	PMID:7889565^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154396	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	C		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LXF1 ensembl:ENSRNOP00000001766	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11274 ensembl:ENSP00000303507	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015123	F		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015123 InterPro:IPR037769	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015123	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000198 InterPro:IPR008936 InterPro:IPR015123	P		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037769	P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:11684658^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Yu, M et al. (2012) Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE 7 e49756 PubMed GONUTS page
↑ Gray, EJ et al. (2014) Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. J. Biol. Chem. 289 35397-408 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Oh, D et al. (2010) Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J. Neurosci. 30 14134-44 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Voncken, JW et al. (1995) Increased neutrophil respiratory burst in bcr-null mutants. Cell 80 719-28 PubMed GONUTS page
↑ Jena, N et al. (2002) Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res. 62 535-41 PubMed GONUTS page
↑ ^6.0 ^6.1 Kaartinen, V et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev. Dyn. 223 517-25 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cho, YJ et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol. Cell. Biol. 27 899-911 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Cunnick, JM et al. (2009) Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol. Cell. Biol. 29 5742-50 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ ^10.0 ^10.1 Kaartinen, V et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 128 4217-27 PubMed GONUTS page

[PMID:23152932-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Yu, M et al. (2012) Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE 7 e49756 PubMed GONUTS page

[PMID:25331951-2] Gray, EJ et al. (2014) Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. J. Biol. Chem. 289 35397-408 PubMed GONUTS page

[PMID:20962234-3] 3.0 ^3.1 ^3.2 ^3.3 Oh, D et al. (2010) Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J. Neurosci. 30 14134-44 PubMed GONUTS page

[PMID:7889565-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Voncken, JW et al. (1995) Increased neutrophil respiratory burst in bcr-null mutants. Cell 80 719-28 PubMed GONUTS page

[PMID:11809706-5] Jena, N et al. (2002) Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res. 62 535-41 PubMed GONUTS page

[PMID:11921339-6] 6.0 ^6.1 Kaartinen, V et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev. Dyn. 223 517-25 PubMed GONUTS page

[PMID:17116687-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cho, YJ et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol. Cell. Biol. 27 899-911 PubMed GONUTS page

[PMID:19703997-8] 8.0 ^8.1 ^8.2 ^8.3 Cunnick, JM et al. (2009) Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol. Cell. Biol. 29 5742-50 PubMed GONUTS page

[PMID:23382219-9] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:11684658-10] 10.0 ^10.1 Kaartinen, V et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 128 4217-27 PubMed GONUTS page

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MOUSE:BCR

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