It is now the 2nd CHALLENGE Period for CACAO Spring 2018! It will end on Monday February 26, 2018 at 05:59 pm CST
This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at

Category:CACAO MSU 2012

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  • MSU teams are joining the Spring 2012 competition for the final round, called the Super Bowl round. Good luck.


CACAO Materials

Student and instructor resources (including many listed on this page) can be found HERE.

Here's a list of the evidence codes that CACAO students may use

  1. IDA: Inferred from Direct Assay
  2. IMP: Inferred from Mutant Phenotype
  3. IGI: Inferred from Genetic Interaction - requires with/from field to be filled in
  4. IEP: Inferred from Expression Pattern
  5. ISO: Inferred from Sequence Orthology - requires with/from field to be filled in
  6. ISA: Inferred from Sequence Alignment - requires with/from field to be filled in
  7. ISM: Inferred from Sequence Model - requires with/from field to be filled in
  8. IGC: Inferred from Genomic Context


Inning/Round Period Start - End (CST)
( TAMU, UNT & UW-P )
1 Annotation Mar. 25, 6:00pm - Apr. 1, 5:59:59pm
1 Challenge Apr. 1, 6:00pm - Apr. 8, 5:59:59pm
Spring 2012 open competition Annotation Apr. 8, 6:00pm - Apr. 15, 5:59:59pm
Spring 2012 open competition Challenge Apr. 15, 6:00pm - Apr. 22, 5:59:59pm

How the annotations will be checked

If any of these conditions are not met, the GO annotation will be marked as incorrect and will not be submitted to UniProt or other databases.

  1. Is the annotation on the right protein’s page? (Is the paper about the right protein and the right organism/strain?)
  2. Is the annotation complete? Does it have the 4 required parts? Does the annotation require either of the additional 2 fields (i.e. does the annotation use an evidence code that needs the with/from field filled in)?
  3. Has the student used information NOT allowed by the CACAO rules (i.e. evidence code or binding terms)?
  4. Do the notes point to a figure/table that supports the annotation? (i.e. is the paper a peer-reviewed article (not a review article)? Is the figure or table experimental data (no models or crystal structures)?) And do all parts of the figure apply to the term (eg, is part B using a different organism or only showing component when the annotation was for a process term)?
  5. Is there a more suitable GO term (more or less specific)?
  6. Does the evidence code fit with the experiment described?
  7. For IGI, ISO, or ISA have they entered the correct accession in the with/from field?
  8. For ISO & ISA, does the protein in the with/from field have a GO annotation that has experimental evidence for that GO term? (i.e. Does the annotation maintain a direct chain of evidence?)
  9. Is the annotation complete, correct and accurate based on the paper? (i.e. will it be submitted to UniProt?)