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Category:Team Gene-Yes

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SUPER BOWL ROUND Spring 2012

StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesPLAFA:Q17SB3Jenni162, Team Gene-Yes2012-04-15 15:04:12 CDTGO:0042540 hemoglobin catabolic process (P)PMID:11904142ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that incubation with plasmepsin IV causes the 17kDa hemoglobin protein to be degraded into an intermediate 14kDa protein.

challenge
requireschangesMOUSE:FOXL2Lulgjur2, Team Gene-Yes2012-04-15 14:36:14 CDTGO:0006309 DNA fragmentation involved in apoptotic nuclear change (P)PMID:16153597ECO:0000315 mutant phenotype evidence used in manual assertion

Figure1: Fragmentation assay of FOXL2

Figure 2: Overexpression of FOXL2 decreased the cell viability of granulose cells in mice

challenge
requireschanges?Lulgjur2, Team Gene-Yes2012-04-15 12:47:13 CDTGO:0034599 cellular response to oxidative stress (Figure 6c shows that overexpression of the trx2 gene has less lipid peroxidation compared to the wild-type.)PMID:20152017IMP: Inferred from Mutant Phenotype
challenge
requireschanges?Lulgjur2, Team Gene-Yes2012-04-15 12:25:08 CDTGO:0055069 zinc ion homeostasis (Figure 2A compares leaf growth in the presence of zinc between the wild-type and the zif1 mutant.)PMID:17277087IMP: Inferred from Mutant Phenotype
challenge
acceptablePLAFA:TPISJenni162, Team Gene-Yes2012-04-15 11:35:56 CDTGO:0004807 triose-phosphate isomerase activity (F)PMID:7903426ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows that the recombinant TPI enzymes are able to convert glyceraldehyde-3-phosphate to dihydroxyacetone phosphate at a much greater rate than the controls.

challenge
requireschangesCLOPE:F7J0A5Jenni162, Team Gene-Yes2012-04-14 09:37:16 CDTGO:0009405 pathogenesis (P)PMID:21628512ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows an increasing level of mouse intestinal damage following more/longer exposure to CPE

challenge
acceptableCLOPE:TACYJenni162, Team Gene-Yes2012-04-14 08:56:34 CDTGO:0044179 hemolysis in other organism (P)PMID:18078439ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3.A shows that the pfo wild type strain grew hemolytic colonies and the pfo mutant strain grew non hemolytic colonies on sheep blood agar.

challenge
acceptableCLOTE:TETXJenni162, Team Gene-Yes2012-04-13 19:12:17 CDTGO:0046929 negative regulation of neurotransmitter secretion (P)PMID:1328520ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that an increase in Tetanus toxin causes a decrease in noradrenaline release from rat brain cells.

challenge


MSU Internal Competition

StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableCLOPE:TACYLulgjur2, Team Gene-Yes2012-04-01 16:49:00 CDTGO:0009405 pathogenesis (P)PMID:21420802ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2: gene knockouts indicated role in pathogenesis

challenge
requireschangesMOUSE:RFX2Lulgjur2, Team Gene-Yes2012-04-01 15:57:13 CDTGO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity (P)PMID:20003220ECO:0000021 physical interaction evidence

transcriptional modulator of the Alf gene,

-inferred from chIP assays (Figure 3)
challenge

Pages in category "Team Gene-Yes"

The following 2 pages are in this category, out of 2 total.


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