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PMID:20003220
| Citation |
Horvath, GC, Kistler, MK and Kistler, WS (2009) RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis. BMC Dev. Biol. 9:63 |
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| Abstract |
Mammalian spermatogenesis involves formation of haploid cells from the male germline and then a complex morphological transformation to generate motile sperm. Focusing on meiotic prophase, some tissue-specific transcription factors are known (A-MYB) or suspected (RFX2) to play important roles in modulating gene expression in pachytene spermatocytes. The current work was initiated to identify both downstream and upstream regulatory connections for Rfx2. |
| Links |
PubMed PMC2797782 Online version:10.1186/1471-213X-9-63 |
| Keywords |
Animals; Base Sequence; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Male; Mice; Mice, Knockout; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb/metabolism; Spermatogenesis; Testis/metabolism; Trans-Activators/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity |
ECO:0000021: |
P |
transcriptional modulator of the Alf gene, -inferred from chIP assays (Figure 3) |
Missing: with/from | ||||
See also
References
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