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MOUSE:RFX2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Rfx2
Protein Name(s) DNA-binding protein RFX2

Regulatory factor X 2

External Links
UniProt P48379
EMBL X76089
AK044439
BC004654
CCDS CCDS28915.1
CCDS50156.1
PIR C55926
RefSeq NP_033082.1
NP_082063.1
UniGene Mm.102
ProteinModelPortal P48379
SMR P48379
BioGrid 202873
IntAct P48379
STRING 10090.ENSMUSP00000002444
PhosphoSite P48379
MaxQB P48379
PaxDb P48379
PRIDE P48379
Ensembl ENSMUST00000002444
ENSMUST00000086801
GeneID 19725
KEGG mmu:19725
UCSC uc008ddf.2
uc008ddg.2
CTD 5990
MGI MGI:106583
eggNOG NOG264634
GeneTree ENSGT00550000074532
HOGENOM HOG000294091
HOVERGEN HBG002753
InParanoid P48379
KO K09173
OMA EAQIYAP
OrthoDB EOG7TF793
PhylomeDB P48379
TreeFam TF321340
NextBio 297132
PRO PR:P48379
Proteomes UP000000589
Bgee P48379
Genevestigator P48379
GO GO:0005634
GO:0003677
GO:0006355
GO:0006351
Gene3D 1.10.10.10
InterPro IPR003150
IPR007668
IPR011991
Pfam PF04589
PF02257
PROSITE PS51526

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

PMID:20003220[1]

ECO:0000021

P

transcriptional modulator of the Alf gene, 

-inferred from chIP assays (Figure 3)

Missing: with/from
CACAO 4208

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0000977,GO:0045944

F

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

PMID:26853561[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:26853561[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:26853561[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:26853561[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:26853561[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

PMID:26248850[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001675

acrosome assembly

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:26162102[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2GV50

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2GV50

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:14743396[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:8289803[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106583
MGI:MGI:1918387
PANTHER:PTN000289470
RGD:1588579
WB:WBGene00000914

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1918387
MGI:MGI:2445208
PANTHER:PTN000289470
RGD:1588579
UniProtKB:Q8HWS3
WB:WBGene00000914

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106582
MGI:MGI:106583
PANTHER:PTN000289470
RGD:1588579

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106583
PANTHER:PTN000289470
RGD:1588579
SGD:S000004166
UniProtKB:Q33E94

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990830

cellular response to leukemia inhibitory factor

PMID:20439489[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1588579

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1588579

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1588579

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1588579

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1588579

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003150
InterPro:IPR007668

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039779

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007668

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003150
InterPro:IPR007668

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Horvath, GC et al. (2009) RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis. BMC Dev. Biol. 9 63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Wu, Y et al. (2016) Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. Sci Rep 6 20435 PubMed GONUTS page
  3. ↑ Shawlot, W et al. (2015) Rfx2 is required for spermatogenesis in the mouse. Genesis 53 604-611 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Kistler, WS et al. (2015) RFX2 Is a Major Transcriptional Regulator of Spermiogenesis. PLoS Genet. 11 e1005368 PubMed GONUTS page
  5. ↑ Wolfe, SA et al. (2004) Regulatory factor X2 (RFX2) binds to the H1t/TE1 promoter element and activates transcription of the testis-specific histone H1t gene. J. Cell. Biochem. 91 375-83 PubMed GONUTS page
  6. ↑ Reith, W et al. (1994) RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol. Cell. Biol. 14 1230-44 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
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