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CLOPE:TACY
Contents
| Species (Taxon ID) | Clostridium perfringens (strain 13 / Type A). (195102) | |
| Gene Name(s) | pfo (synonyms: pfoA, pfoR) | |
| Protein Name(s) | Perfringolysin O
Theta-toxin Thiol-activated cytolysin | |
| External Links | ||
| UniProt | P0C2E9 | |
| EMBL | M81080 BA000016 | |
| PIR | B43577 | |
| RefSeq | NP_561079.1 | |
| PDB | 1M3I 1M3J 1PFO 2BK1 2BK2 | |
| PDBsum | 1M3I 1M3J 1PFO 2BK1 2BK2 | |
| DisProt | DP00280 | |
| ProteinModelPortal | P0C2E9 | |
| SMR | P0C2E9 | |
| STRING | 195102.CPE0163 | |
| TCDB | 1.C.12.1.1 | |
| EnsemblBacteria | BAB79869 | |
| GeneID | 988404 | |
| KEGG | cpe:CPE0163 | |
| PATRIC | 19494208 | |
| eggNOG | NOG04845 | |
| HOGENOM | HOG000056095 | |
| KO | K11031 | |
| OMA | THKTWDG | |
| OrthoDB | EOG6S7XT6 | |
| BioCyc | CPER195102:GJFM-188-MONOMER | |
| EvolutionaryTrace | P0C2E9 | |
| Proteomes | UP000000818 | |
| GO | GO:0020002 GO:0016021 GO:0015485 GO:0044179 GO:0009405 | |
| Gene3D | 3.90.840.10 | |
| InterPro | IPR001869 | |
| Pfam | PF01289 | |
| PRINTS | PR01400 | |
| SUPFAM | SSF56978 | |
| PROSITE | PS00481 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 2: gene knockouts indicated role in pathogenesis |
complete | |||||
| GO:0044179 |
hemolysis in other organism |
ECO:0000315 |
P |
Figure 3.A shows that the pfo wild type strain grew hemolytic colonies and the pfo mutant strain grew non hemolytic colonies on sheep blood agar. |
complete | |||||
| GO:0015485 |
cholesterol binding |
ECO:0000315 |
F |
Figure 5 |
complete | |||||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 2 shows that both theta and alpha toxins contribute to myonecrosis in mice after 4 hours. |
complete | |||||
|
involved_in |
GO:0044179 |
hemolysis in other organism |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015485 |
cholesterol binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019835 |
cytolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044179 |
hemolysis in other organism |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Uzal, FA & McClane, BA (2011) Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections. Vet. Microbiol. 153 37-43 PubMed GONUTS page
- ↑ 2.0 2.1 Sayeed, S et al. (2008) Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol. Microbiol. 67 15-30 PubMed GONUTS page
- ↑ Verherstraeten, S et al. (2015) Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel) 7 1702-21 PubMed GONUTS page
- ↑ Stevens, DL et al. (1997) Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J. Infect. Dis. 176 189-95 PubMed GONUTS page
