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PMID:26008232
| Citation |
Verherstraeten, S, Goossens, E, Valgaeren, B, Pardon, B, Timbermont, L, Haesebrouck, F, Ducatelle, R, Deprez, P, Wade, KR, Tweten, R and Van Immerseel, F (2015) Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel) 7:1702-21 |
|---|---|
| Abstract |
The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as θ toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Membrane-bound monomers undergo structural changes that culminate in the formation of an oligomerized prepore complex on the membrane surface. The prepore then undergoes conversion into the bilayer-spanning pore measuring approximately 250-300 Å in diameter. PFO is expressed in nearly all identified C. perfringens strains and harbors interesting traits that suggest a potential undefined role for PFO in disease development. Research has demonstrated a role for PFO in gas gangrene progression and bovine necrohemorrhagic enteritis, but there is limited data available to determine if PFO also functions in additional disease presentations caused by C. perfringens. This review summarizes the known structural and functional characteristics of PFO, while highlighting recent insights into the potential contributions of PFO to disease pathogenesis. |
| Links |
PubMed PMC4448169 Online version:10.3390/toxins7051702 |
| Keywords |
Animals; Bacterial Toxins/chemistry; Bacterial Toxins/genetics; Bacterial Toxins/metabolism; Bacterial Toxins/toxicity; Cell Membrane/metabolism; Clostridium perfringens/genetics; Clostridium perfringens/metabolism; Hemolysin Proteins/chemistry; Hemolysin Proteins/genetics; Hemolysin Proteins/metabolism; Hemolysin Proteins/toxicity; Humans |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0015485: cholesterol binding |
ECO:0000315: |
F |
Figure 5 |
complete | ||||
Notes
See also
References
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