PMID:9207366

Citation	Stevens, DL, Tweten, RK, Awad, MM, Rood, JI and Bryant, AE (1997) Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J. Infect. Dis. 176:189-95
Abstract	The rapid extension of necrosis and an absence of polymorphonuclear leukocytes (PMNL) at the site of infection are two hallmarks of Clostridium perfringens gas gangrene. While both alpha and theta toxins profoundly affect PMNL function and viability in vitro, their roles in muscle destruction and impairment of the inflammatory response in vivo have not been investigated. Comparative histopathologic examinations were performed on animals infected with either wild-type C. perfringens, or isogenic, toxin-deficient mutants of C. perfringens. Tissue destruction was modest in animals infected with the alpha toxin-deficient mutant; destruction was more pronounced in tissues infected with the theta toxin-deficient mutant or the wild-type strain. alpha and theta toxins also displayed differing abilities to modulate the inflammatory response. Histopathologic studies in which recombinant toxins were injected together with killed, washed C. perfringens further substantiated these tissue-destructive and differential antiinflammatory effects.
Links	PubMed
Keywords	Animals; Bacterial Toxins/immunology; Bacterial Toxins/toxicity; Calcium-Binding Proteins; Female; Gas Gangrene/immunology; Gas Gangrene/pathology; Hemolysin Proteins; Immunization; Mice; Necrosis; Neutrophils/physiology; Type C Phospholipases
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CLOPE:TACY		GO:0009405: pathogenesis	ECO:0000315:		P		Figure 2 shows that both theta and alpha toxins contribute to myonecrosis in mice after 4 hours.	complete CACAO 11370

References

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