User:Aborel

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:IL1RA	2014-01-26 14:26:39 CST	GO:0002439 chronic inflammatory response to antigenic stimulus (P)	PMID:24383930	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows reduced inflammation and build up of CFS after administration of IL-1Ra	challenge
unacceptable	HUMAN:IRAK2	2014-01-26 17:59:47 CST	GO:0007165 signal transduction (P)	PMID:23724040	ECO:0000314 direct assay evidence used in manual assertion	Figure 6 suggests IRAK2 regulates expression of UPR signaling protein.	challenge
unacceptable	HUMAN:IL8	2014-01-26 18:03:51 CST	GO:0005153 interleukin-8 receptor binding (F)	PMID:24455739	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows that IL-8 production is directly associated with TNF-alpha concentrations	challenge
unacceptable	HUMAN:IL6	2014-01-26 18:24:09 CST	GO:0042127 regulation of cell proliferation (P)	PMID:24453423	ECO:0000314 direct assay evidence used in manual assertion	Table 4 says that increased IL-6 concentrations show early endothelial activation in RA patients	challenge
unacceptable	HUMAN:IL6	2014-01-26 18:30:23 CST	GO:0070102 interleukin-6-mediated signaling pathway (P)	PMID:24455461	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows that interaction of PMs with microbacteria occurred with increased IL-6 concentrations	challenge
unacceptable	MOUSE:IL6	2014-02-11 12:43:58 CST	GO:0002675 positive regulation of acute inflammatory response (P)	PMID:24223643	ECO:0000314 direct assay evidence used in manual assertion	Figure 4 shows that inhibition of IL-6 using MR16-1 greatly increased the recovery time of spinal cord injury mice because of a reduced inflammatory response which is normally positively regulated by IL-6.	challenge
unacceptable	MOUSE:IL6	2014-02-11 14:24:54 CST	GO:0032966 negative regulation of collagen biosynthetic process (P)	GO_REF:24449804	ECO:0000314 direct assay evidence used in manual assertion	Figure 4 shows the dilation of aortic tissue in mice with increased concentrations of IL-6 due to the break down of collagen.	challenge
unacceptable	MOUSE:IL6	2014-02-11 15:06:58 CST	GO:0009409 response to cold (P)	PMID:24416310	ECO:0000314 direct assay evidence used in manual assertion	Figure 3C shows a great increase in UCP1 protein because of IL-6 when under cold exposure conditions.	challenge

acceptable:0
unacceptable:8
requires_changes:0
flagged:0

Annotations challenged by Aborel

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Fclingen, Team What the Fox Says	HUMAN:EAF1	GO:0030097 - hemopoiesis (P)	PMID:24445282	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
unacceptable	Fclingen, Team What the Fox Says	HUMAN:EAF1	GO:0010629 - negative regulation of gene expression (P)	PMID:24445282	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
unacceptable	Cford, Team What the Fox Says	HUMAN:PML	GO:0051607 - defense response to virus (P)	PMID:24407287	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (Figure 1 (A, B) shows that injection of Danio rerio with triple tnnt morpholino oligonucleotides (tnnt2c, tnnt3a, tnnt3b)had a decreased showing of myofibril striation at 28 hours post fertilization. This shows the necessity of troponin-based genes for muscle differentiation.)	PMID:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4 UniProtKB:Q9I8U9	challenge	C: 1
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (When comparing the control and the experimental triple tnnt (tnnt2c, tnnt3a, tnnt3b) morpholino oligonucleotide-injected panels in Figure 1 (C' and D'), it is seen that at 48 hours post-fertilization, T12 (a titin epitope) is delocalized from normal Z line locations.)	PMID:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4_DANRE UniProtKB:Q9I8U9_DANRE	challenge	C: 1
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (When comparing the control and the experimental triple tnnt (tnnt2c, tnnt3a, tnnt3b) morpholino oligonucleotide-injected panels in Figure 1 (C'' and D''), it is seen that at 48 hours post-fertilization, actin is delocalized from normal muscle striations to be randomly dispersed in muscle.)	PMID:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4_DANRE UniProtKB:Q9I8U9_DANRE	challenge	C: 1
unacceptable	Evazquez, Team 50K Volts	?	GO:0060299 - negative regulation of sarcomere organization (By disrupting the expression of different members of the troponin T family, and comparing wildtype and mutant zebrafish, it has been concluded that troponin is required for normal myofibrillogenesis. In the absence of troponin, sarcomeres do not form, instead stacks of thick filaments, expanded Z lines and aggregates of filamentous actin can be observed. Methods used to display the results include transmission electron microscopy, immunofluorescence assays, electron micrographs, electron microscopy and immunostaining.)	PMID:21245197	IMP: Inferred from Mutant Phenotype	challenge	C: 1
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (In Figure 1 (E and F), Danio rerio is stained to show that at 48 hours post-fertilization T11 (a titin epitope)is delocalized from the I-band/A-band portions in muscle to become scattered in the cytoplasm. This is after triple tnnt (tnnt2c, tnnt3a, tnnt3b) morpholino oligonucleotide injection.)	PMID:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4_DANRE UniProtKB:Q9I8U9_DANRE	challenge	C: 1
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (In Figure 1 (G and H), Danio rerio is stained to show that at 48 hours post-fertilization myomesin (an endline protein that is found in the M-band of muscle) is delocalized to become scattered in the cytoplasm of muscle. This is after triple tnnt (tnnt2c, tnnt3a, tnnt3b) morpholino oligonucleotide injection.)	21245197:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4_DANRE UniProtKB:Q9I8U9_DANRE	challenge	C: 3
unacceptable	Evazquez, Team 50K Volts	?	GO:0060298 - positive regulation of sarcomere organization (In Figure 1 (I and J), Danio rerio is stained to show that at 48 hours post-fertilization tropomyosin (a protein that is important in actin filaments) is organizational control is significantly delocalized from the thin actin filaments after triple tnnt (tnnt2c, tnnt3a, tnnt3b) morpholino oligonucleotide injection.)	PMID:21245197	IGI: Inferred from Genetic Interaction Zfin:ZDB-GENE-000322-3 Zfin:ZDB-GENE-030520-2 UniProtKB:Q7ZZW4_DANRE UniProtKB:Q9I8U9_DANRE	challenge	C: 1
unacceptable	Sprem, Team On a Boat	HUMAN:RYR1	GO:0006936 - muscle contraction (P)	PMID:2298749	ECO:0000255 match to sequence model evidence used in manual assertion	challenge	C: 4
unacceptable	Sprem, Team On a Boat	HUMAN:HXK1	GO:0004396 - hexokinase activity (F)	PMID:9531504	ECO:0000255 match to sequence model evidence used in manual assertion	challenge	C: 3
unacceptable	Gandii2, Team Protein Titans	GIAIA:E1F6D1	GO:0060627 - regulation of vesicle-mediated transport (P)	PMID:20532229	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 6
unacceptable	Bmanieri, Team Chicken Day	HUMAN:COGA1	GO:0008544 - epidermis development (P)	PMID:16754661	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
updatedbyinstructor	Aross, Team BAMF	DROME:ABL	GO:0010592 - positive regulation of lamellipodium assembly (P)	PMID:24466097	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4
updatedbyinstructor	Aross, Team BAMF	DROME:ABL	GO:0010977 - negative regulation of neuron projection development (P)	PMID:24466097	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4
updatedbyinstructor	Kdiawara, Team Lobster Soul	HUMAN:HS90B	GO:0097435 - supramolecular fiber organization (P)	PMID:24466266	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 8
unacceptable	Kdiawara, Team Lobster Soul	9HIV1:Q2ME96	GO:2000353 - positive regulation of endothelial cell apoptotic process (P)	PMID:24318111	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2
unacceptable	Csobelman, Team Lobster Soul	MOUSE:FOXP2	GO:0042297 - vocal learning (P)	PMID:15983371	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
updatedbyinstructor	Csobelman, Team Lobster Soul	CHICK:MLE1	GO:0043520 - regulation of myosin II filament assembly (P)	PMID:1464306	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 6 fixed by Djgulizia
unacceptable	Csobelman, Team Lobster Soul	MOUSE:P53	GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (P)	PMID:12952892	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3

0 annotations fixed by Aborel

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