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HUMAN:COGA1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) COL16A1
Protein Name(s) Collagen alpha-1(XVI) chain
External Links
UniProt Q07092
EMBL M92642
AC114488
AB209571
X14963
X15038
S57132
AF370368
CCDS CCDS41297.1
PIR S23810
RefSeq NP_001847.3
UniGene Hs.368921
ProteinModelPortal Q07092
SMR Q07092
BioGrid 107703
IntAct Q07092
MINT MINT-6743139
STRING 9606.ENSP00000362776
PhosphoSite Q07092
DMDM 143811380
MaxQB Q07092
PaxDb Q07092
PRIDE Q07092
DNASU 1307
Ensembl ENST00000373672
GeneID 1307
KEGG hsa:1307
UCSC uc001btj.1
uc001btk.1
CTD 1307
GeneCards GC01M032117
H-InvDB HIX0028602
HGNC HGNC:2193
HPA HPA027235
HPA027237
MIM 120326
neXtProt NX_Q07092
PharmGKB PA26709
eggNOG NOG12793
GeneTree ENSGT00770000120455
HOGENOM HOG000085653
HOVERGEN HBG071631
InParanoid Q07092
OMA PGLDNCA
OrthoDB EOG779NXQ
PhylomeDB Q07092
TreeFam TF332900
Reactome REACT_121139
REACT_13552
REACT_150401
ChiTaRS COL16A1
GeneWiki Collagen,_type_XVI,_alpha_1
GenomeRNAi 1307
NextBio 5349
PRO PR:Q07092
Proteomes UP000005640
Bgee Q07092
CleanEx HS_COL16A1
ExpressionAtlas Q07092
Genevestigator Q07092
GO GO:0005597
GO:0005788
GO:0005576
GO:0005578
GO:0005178
GO:0007155
GO:0071230
GO:0030574
GO:0022617
GO:0030198
GO:0007565
GO:0007229
InterPro IPR008160
IPR013320
IPR001791
Pfam PF01391
SMART SM00210
SUPFAM SSF49899

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008544

epidermis development

PMID:16754661[1]

ECO:0000314

P

Epidermis

complete
CACAO 9305

GO:0051894

positive regulation of focal adhesion assembly

PMID:24466237[2]

ECO:0000314

P

Figure 2A displays that over expression of Collagen XVI increases interaction with integrin-linked kinase/kindlin-1 only at the focal adhesions.

complete
CACAO 9311

GO:0033622

integrin activation

PMID:16754661[1]

ECO:0000314

P

Figure 3 depicts via fluorescence tagging that collagen XVI induces recruitment of integrins α1β1 and α2β1 into focal adhesion plaques.

complete
CACAO 9320

GO:0033627

cell adhesion mediated by integrin

PMID:16754661[1]

ECO:0000314

P

Figure 2 depicts (via cell adhesion absorbance) cell attachment to collagen XVI and its inhibition by monoclonal antibodies against α1 and α2 integrin subunits.

complete
CACAO 9321

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:28327460[3]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(CL:0002540)|occurs_in:(CL:0002570)|occurs_in:(CL:0002551)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)|part_of:(CL:0002570)|part_of:(CL:0002551)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:27068509[4]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28344315[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002371)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:28344315[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

occurs_in:(UBERON:0002371)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)|part_of:(UBERON:0001911)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:28675934[6]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0003688)|occurs_in:(UBERON:0001911)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:25037231[7]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:25037231[7]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27068509[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

involved_in

GO:0033627

cell adhesion mediated by integrin

PMID:16754661[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033622

integrin activation

PMID:16754661[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051894

positive regulation of focal adhesion assembly

PMID:24466237[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:16754661[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

PMID:16754661[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051894

positive regulation of focal adhesion assembly

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002770936
UniProtKB:Q07092

P

Seeded From UniProt

complete

involved_in

GO:0033627

cell adhesion mediated by integrin

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002770936
UniProtKB:Q07092

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88445
MGI:MGI:88446
MGI:MGI:88452
MGI:MGI:88453
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067

C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1095415
MGI:MGI:2152695
MGI:MGI:2672118
MGI:MGI:88451
PANTHER:PTN002513067
WB:WBGene00001263
ZFIN:ZDB-GENE-030131-2281

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002770936
UniProtKB:Q07092

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88452
MGI:MGI:88468
PANTHER:PTN002513067
RGD:61817
RGD:70936
RGD:727898
UniProtKB:P02452
UniProtKB:P02458
UniProtKB:P02461
UniProtKB:P08123
UniProtKB:Q9BXS0

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104687
MGI:MGI:2672118
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067
UniProtKB:P02461
UniProtKB:P02462
UniProtKB:P53420

F

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002770936
UniProtKB:Q07092

F

Seeded From UniProt

complete

involved_in

GO:0071230

cellular response to amino acid stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8BLX7
ensembl:ENSMUSP00000035802

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:1284248[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005597

collagen type XVI trimer

PMID:1284248[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007229

integrin-mediated signaling pathway

PMID:16754661[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

Reactome:R-HSA-1474244

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8944219
Reactome:R-HSA-2089971
Reactome:R-HSA-2022073

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-2327695
Reactome:R-HSA-2089971

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0176

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Eble, JA et al. (2006) Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. J. Biol. Chem. 281 25745-56 PubMed GONUTS page
  2. 2.0 2.1 Bedal, KB et al. (2014) Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma. PLoS ONE 9 e86777 PubMed GONUTS page
  3. 3.0 3.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  4. 4.0 4.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  5. 5.0 5.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
  6. 6.0 6.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. 9.0 9.1 Yamaguchi, N et al. (1992) Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. J. Biochem. 112 856-63 PubMed GONUTS page