HUMAN:COGA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	COL16A1
Protein Name(s)	Collagen alpha-1(XVI) chain
External Links
UniProt	Q07092
EMBL	M92642 AC114488 AB209571 X14963 X15038 S57132 AF370368
CCDS	CCDS41297.1
PIR	S23810
RefSeq	NP_001847.3
UniGene	Hs.368921
ProteinModelPortal	Q07092
SMR	Q07092
BioGrid	107703
IntAct	Q07092
MINT	MINT-6743139
STRING	9606.ENSP00000362776
PhosphoSite	Q07092
DMDM	143811380
MaxQB	Q07092
PaxDb	Q07092
PRIDE	Q07092
DNASU	1307
Ensembl	ENST00000373672
GeneID	1307
KEGG	hsa:1307
UCSC	uc001btj.1 uc001btk.1
CTD	1307
GeneCards	GC01M032117
H-InvDB	HIX0028602
HGNC	HGNC:2193
HPA	HPA027235 HPA027237
MIM	120326
neXtProt	NX_Q07092
PharmGKB	PA26709
eggNOG	NOG12793
GeneTree	ENSGT00770000120455
HOGENOM	HOG000085653
HOVERGEN	HBG071631
InParanoid	Q07092
OMA	PGLDNCA
OrthoDB	EOG779NXQ
PhylomeDB	Q07092
TreeFam	TF332900
Reactome	REACT_121139 REACT_13552 REACT_150401
ChiTaRS	COL16A1
GeneWiki	Collagen,_type_XVI,_alpha_1
GenomeRNAi	1307
NextBio	5349
PRO	PR:Q07092
Proteomes	UP000005640
Bgee	Q07092
CleanEx	HS_COL16A1
ExpressionAtlas	Q07092
Genevestigator	Q07092
GO	GO:0005597 GO:0005788 GO:0005576 GO:0005578 GO:0005178 GO:0007155 GO:0071230 GO:0030574 GO:0022617 GO:0030198 GO:0007565 GO:0007229
InterPro	IPR008160 IPR013320 IPR001791
Pfam	PF01391
SMART	SM00210
SUPFAM	SSF49899

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008544	epidermis development	PMID:16754661^[1]	ECO:0000314			P		Epidermis	complete CACAO 9305
	GO:0051894	positive regulation of focal adhesion assembly	PMID:24466237^[2]	ECO:0000314			P		Figure 2A displays that over expression of Collagen XVI increases interaction with integrin-linked kinase/kindlin-1 only at the focal adhesions.	complete CACAO 9311
	GO:0033622	integrin activation	PMID:16754661^[1]	ECO:0000314			P		Figure 3 depicts via fluorescence tagging that collagen XVI induces recruitment of integrins α1β1 and α2β1 into focal adhesion plaques.	complete CACAO 9320
	GO:0033627	cell adhesion mediated by integrin	PMID:16754661^[1]	ECO:0000314			P		Figure 2 depicts (via cell adhesion absorbance) cell attachment to collagen XVI and its inhibition by monoclonal antibodies against α1 and α2 integrin subunits.	complete CACAO 9321
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28327460^[3]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(CL:0002540)\|occurs_in:(CL:0002570)\|occurs_in:(CL:0002551)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:27068509^[4]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28344315^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28675934^[6]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)\|occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:25037231^[7]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:25037231^[7]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27068509^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	PMID:16754661^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033622	integrin activation	PMID:16754661^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:24466237^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:16754661^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:16754661^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002770936 UniProtKB:Q07092	P		Seeded From UniProt	complete
involved_in	GO:0033627	cell adhesion mediated by integrin	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002770936 UniProtKB:Q07092	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88445 MGI:MGI:88446 MGI:MGI:88452 MGI:MGI:88453 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067	C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095415 MGI:MGI:2152695 MGI:MGI:2672118 MGI:MGI:88451 PANTHER:PTN002513067 WB:WBGene00001263 ZFIN:ZDB-GENE-030131-2281	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002770936 UniProtKB:Q07092	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88452 MGI:MGI:88468 PANTHER:PTN002513067 RGD:61817 RGD:70936 RGD:727898 UniProtKB:P02452 UniProtKB:P02458 UniProtKB:P02461 UniProtKB:P08123 UniProtKB:Q9BXS0	C		Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104687 MGI:MGI:2672118 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067 UniProtKB:P02461 UniProtKB:P02462 UniProtKB:P53420	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002770936 UniProtKB:Q07092	F		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BLX7 ensembl:ENSMUSP00000035802	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:1284248^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005597	collagen type XVI trimer	PMID:1284248^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:16754661^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8944219 Reactome:R-HSA-2089971 Reactome:R-HSA-2022073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2327695 Reactome:R-HSA-2089971	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0176	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Eble, JA et al. (2006) Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. J. Biol. Chem. 281 25745-56 PubMed GONUTS page
↑ ^2.0 ^2.1 Bedal, KB et al. (2014) Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma. PLoS ONE 9 e86777 PubMed GONUTS page
↑ ^3.0 ^3.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^4.0 ^4.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^5.0 ^5.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ ^6.0 ^6.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Yamaguchi, N et al. (1992) Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. J. Biochem. 112 856-63 PubMed GONUTS page

[PMID:16754661-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Eble, JA et al. (2006) Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. J. Biol. Chem. 281 25745-56 PubMed GONUTS page

[PMID:24466237-2] 2.0 ^2.1 Bedal, KB et al. (2014) Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma. PLoS ONE 9 e86777 PubMed GONUTS page

[PMID:28327460-3] 3.0 ^3.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:27068509-4] 4.0 ^4.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:28344315-5] 5.0 ^5.1 Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:28675934-6] 6.0 ^6.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-7] 7.0 ^7.1 ^7.2 ^7.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1284248-9] 9.0 ^9.1 Yamaguchi, N et al. (1992) Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. J. Biochem. 112 856-63 PubMed GONUTS page

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HUMAN:COGA1

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