HUMAN:IL1RA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL1RN (synonyms: IL1F3, IL1RA)
Protein Name(s)	Interleukin-1 receptor antagonist protein IL-1RN IL-1ra IRAP ICIL-1RA IL1 inhibitor
External Links
UniProt	P18510
EMBL	X53296 X52015 M63099 X64532 U65590 U65590 U65590 M55646 X84348 AY196903 AK290898 AK290926 AC024704 CH471217 BC009745 AF043143 BN000002
CCDS	CCDS2113.1 CCDS2114.1 CCDS2115.1 CCDS46396.1
PIR	A40956 I37893
RefSeq	NP_000568.1 NP_776213.1 NP_776214.1 NP_776215.1 XP_005263718.1 XP_006712560.1
UniGene	Hs.81134
PDB	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
PDBsum	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
ProteinModelPortal	P18510
SMR	P18510
BioGrid	109772
DIP	DIP-3513N
IntAct	P18510
MINT	MINT-1522172
STRING	9606.ENSP00000259206
DrugBank	DB06372
DMDM	124312
MaxQB	P18510
PaxDb	P18510
PRIDE	P18510
DNASU	3557
Ensembl	ENST00000259206 ENST00000354115 ENST00000361779 ENST00000409052 ENST00000409930
GeneID	3557
KEGG	hsa:3557
UCSC	uc002tiy.3 uc002tiz.3 uc002tja.3
CTD	3557
GeneCards	GC02P113864
HGNC	HGNC:6000
HPA	CAB009633 HPA001482
MIM	147679 612628 612852
neXtProt	NX_P18510
Orphanet	210115
PharmGKB	PA29816
eggNOG	NOG46710
GeneTree	ENSGT00530000062899
HOGENOM	HOG000231506
HOVERGEN	HBG052099
InParanoid	P18510
KO	K05481
OMA	IHGGKLC
OrthoDB	EOG7X6M1M
PhylomeDB	P18510
TreeFam	TF300203
Reactome	REACT_22442
ChiTaRS	IL1RN
EvolutionaryTrace	P18510
GeneWiki	Interleukin_1_receptor_antagonist
GenomeRNAi	3557
NextBio	13886
PRO	PR:P18510
Proteomes	UP000005640
Bgee	P18510
CleanEx	HS_IL1RN
ExpressionAtlas	P18510
Genevestigator	P18510
GO	GO:0005737 GO:0005615 GO:0070062 GO:0005622 GO:0005886 GO:0005152 GO:0005149 GO:0045352 GO:0045353 GO:0005150 GO:0005151 GO:0006953 GO:0019752 GO:0071874 GO:0002439 GO:0007565 GO:0001660 GO:0006955 GO:0030073 GO:0006629 GO:0007613 GO:0043066 GO:0030336 GO:0001960 GO:0014050 GO:0034115 GO:2000660 GO:0045837 GO:0043507 GO:0014823 GO:0042493 GO:0051384 GO:0070555 GO:0070670 GO:0032496 GO:0042594 GO:0019233
InterPro	IPR008996 IPR020877 IPR000975 IPR027166 IPR003297
PANTHER	PTHR10078:SF6
Pfam	PF00340
PRINTS	PR00264 PR01360
SUPFAM	SSF50353
PROSITE	PS00253

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002439	chronic inflammatory response to antigenic stimulus	PMID:24383930^[1]	ECO:0000314			P		Figure 3 shows reduced inflammation and build up of CFS after administration of IL-1Ra	complete CACAO 9209
part_of	GO:0070062	extracellular exosome	PMID:19056867^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	PMID:2137200^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	PMID:2139180^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:10443688^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045353	interleukin-1 type II receptor antagonist activity	PMID:1830582^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045352	interleukin-1 type I receptor antagonist activity	PMID:1828071^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:2139180^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12483741^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10443688^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005152	interleukin-1 receptor antagonist activity	PMID:2139180^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005151	interleukin-1, type II receptor binding	PMID:1830582^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27930	F		Seeded From UniProt	complete
enables	GO:0005150	interleukin-1, type I receptor binding	PMID:1828071^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13504	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:7629520^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859324 MGI:MGI:1916927 MGI:MGI:2449929 MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96543 PANTHER:PTN000008572	P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 UniProtKB:P01584	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008646 RGD:621159 UniProtKB:P18510	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859324 MGI:MGI:1916927 MGI:MGI:2449929 MGI:MGI:96543 PANTHER:PTN000008572 RGD:2891 RGD:621159 UniProtKB:P01584 UniProtKB:P18510	C		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000008572 RGD:621159 UniProtKB:P18510	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25085 ensembl:ENSMUSP00000110126	C		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25085 ensembl:ENSMUSP00000110126	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25085 ensembl:ENSMUSP00000110126	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25085 ensembl:ENSMUSP00000110126	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	F		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003297	F		Seeded From UniProt	complete
enables	GO:0005152	interleukin-1 receptor antagonist activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039348	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR020877	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
involved_in	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039348	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:9185517^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9185517^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2137200^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005152	interleukin-1 receptor antagonist activity	PMID:2137200^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	PMID:2137200^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001960	negative regulation of cytokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005152	P		Seeded From UniProt	complete
enables	GO:0005152	interleukin-1 receptor antagonist activity	PMID:7629520^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8937654 Reactome:R-HSA-445757	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Singh, N et al. (2014) The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation 11 1 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hannum, CH et al. (1990) Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343 336-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Carter, DB et al. (1990) Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344 633-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Franchimont, D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84 2834-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Granowitz, EV et al. (1991) Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J. Biol. Chem. 266 14147-50 PubMed GONUTS page
↑ ^7.0 ^7.1 Dripps, DJ et al. (1991) Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266 10331-6 PubMed GONUTS page
↑ Aksentijevich, I et al. (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46 3340-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Muzio, M et al. (1995) Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. J. Exp. Med. 182 623-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 Gabay, C et al. (1997) Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. J. Clin. Invest. 99 2930-40 PubMed GONUTS page

[PMID:24383930-1] Singh, N et al. (2014) The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation 11 1 PubMed GONUTS page

[PMID:19056867-2] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:2137200-3] 3.0 ^3.1 ^3.2 ^3.3 Hannum, CH et al. (1990) Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343 336-40 PubMed GONUTS page

[PMID:2139180-4] 4.0 ^4.1 ^4.2 Carter, DB et al. (1990) Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344 633-8 PubMed GONUTS page

[PMID:10443688-5] 5.0 ^5.1 Franchimont, D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84 2834-9 PubMed GONUTS page

[PMID:1830582-6] 6.0 ^6.1 Granowitz, EV et al. (1991) Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J. Biol. Chem. 266 14147-50 PubMed GONUTS page

[PMID:1828071-7] 7.0 ^7.1 Dripps, DJ et al. (1991) Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266 10331-6 PubMed GONUTS page

[PMID:12483741-8] Aksentijevich, I et al. (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46 3340-8 PubMed GONUTS page

[PMID:7629520-9] 9.0 ^9.1 Muzio, M et al. (1995) Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. J. Exp. Med. 182 623-8 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9185517-11] 11.0 ^11.1 Gabay, C et al. (1997) Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. J. Clin. Invest. 99 2930-40 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

HUMAN:IL1RA

Contents

Annotations

Notes

References

a

c

e

h

i

l

m

n

p

r

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools