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PMID:24383930
| Citation |
Singh, N, Hopkins, SJ, Hulme, S, Galea, JP, Hoadley, M, Vail, A, Hutchinson, PJ, Grainger, S, Rothwell, NJ, King, AT and Tyrrell, PJ (2014) The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial. J Neuroinflammation 11:1 |
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| Abstract |
Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. |
| Links |
PubMed PMC3892121 Online version:10.1186/1742-2094-11-1 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002439: chronic inflammatory response to antigenic stimulus |
ECO:0000314: |
P |
Figure 3 shows reduced inflammation and build up of CFS after administration of IL-1Ra |
complete | ||||
See also
References
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