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PMID:24455461

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Citation

Singh, PP and Goyal, A (2013) Interleukin-6: a potent biomarker of mycobacterial infection. Springerplus 2:686

Abstract

Human tuberculosis (TB), a chronic inflammatory disease is caused by Mycobacterium tuberculosis, a facultative intramacrophage pathogen. The highly complex interactions between mycobacteria and macrophages (MΦs), characterized in part by the induction and elaboration of several cytokines including IL-1, IL-6, IL-10, IL-12 p40 and IL-12 p70 are not yet fully understood. The cytokines are known to have important bearing on the pathogenesis and host defense during TB. We thus studied different patterns of cytokines elaborated by mouse peritoneal macrophages (PMs) following their interaction with live and heat-killed, virulent and avirulent, and pathogenic and non-pathogenic mycobacteria, in vitro.

Links

PubMed Online version:10.1186/2193-1801-2-686

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:IL6

GO:0070102: interleukin-6-mediated signaling pathway

ECO:0000314:

P

Figure 2 shows that interaction of PMs with microbacteria occurred with increased IL-6 concentrations

complete
CACAO 9222

See also

References

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