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PMID:24455461
| Citation |
Singh, PP and Goyal, A (2013) Interleukin-6: a potent biomarker of mycobacterial infection. Springerplus 2:686 |
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| Abstract |
Human tuberculosis (TB), a chronic inflammatory disease is caused by Mycobacterium tuberculosis, a facultative intramacrophage pathogen. The highly complex interactions between mycobacteria and macrophages (MΦs), characterized in part by the induction and elaboration of several cytokines including IL-1, IL-6, IL-10, IL-12 p40 and IL-12 p70 are not yet fully understood. The cytokines are known to have important bearing on the pathogenesis and host defense during TB. We thus studied different patterns of cytokines elaborated by mouse peritoneal macrophages (PMs) following their interaction with live and heat-killed, virulent and avirulent, and pathogenic and non-pathogenic mycobacteria, in vitro. |
| Links |
PubMed Online version:10.1186/2193-1801-2-686 |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0070102: interleukin-6-mediated signaling pathway |
ECO:0000314: |
P |
Figure 2 shows that interaction of PMs with microbacteria occurred with increased IL-6 concentrations |
complete | ||||
See also
References
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