MOUSE:IL6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Il6 (synonyms: Il-6)
Protein Name(s)	Interleukin-6 IL-6 B-cell hybridoma growth factor Interleukin HP-1
External Links
UniProt	P08505
EMBL	X06203 M20572 J03783 X54542 AK150440 X51457 M24221
CCDS	CCDS19153.1
PIR	A30531
RefSeq	NP_112445.1
UniGene	Mm.1019
PDB	2L3Y
PDBsum	2L3Y
ProteinModelPortal	P08505
SMR	P08505
BioGrid	200641
IntAct	P08505
PhosphoSite	P08505
MaxQB	P08505
PRIDE	P08505
Ensembl	ENSMUST00000026845
GeneID	16193
KEGG	mmu:16193
UCSC	uc008wuu.1
CTD	3569
MGI	MGI:96559
eggNOG	NOG48083
GeneTree	ENSGT00390000000878
HOGENOM	HOG000236330
HOVERGEN	HBG000471
InParanoid	P08505
KO	K05405
OMA	FNQETCL
OrthoDB	EOG7QG453
PhylomeDB	P08505
TreeFam	TF335984
Reactome	REACT_199118 REACT_206033 REACT_247448 REACT_263321
EvolutionaryTrace	P08505
NextBio	289109
PRO	PR:P08505
Proteomes	UP000000589
Bgee	P08505
CleanEx	MM_IL6
ExpressionAtlas	P08505
Genevestigator	P08505
GO	GO:0005737 GO:0009897 GO:0005615 GO:0005896 GO:0005125 GO:0005138 GO:0006953 GO:0007568 GO:0046849 GO:0060445 GO:0016049 GO:0045454 GO:0071549 GO:0070301 GO:0071347 GO:0071222 GO:0071356 GO:0050829 GO:0050830 GO:0042832 GO:0051607 GO:0031018 GO:0060664 GO:0070091 GO:0042593 GO:0070102 GO:0046716 GO:0002262 GO:0008285 GO:0045079 GO:0032966 GO:0043154 GO:0050710 GO:0045721 GO:0046888 GO:0048635 GO:1901215 GO:0006469 GO:0031175 GO:0001781 GO:0002675 GO:0043065 GO:0050871 GO:0032722 GO:0045740 GO:0050679 GO:0070374 GO:0051024 GO:0032755 GO:0045666 GO:0045429 GO:0033138 GO:0033160 GO:0051897 GO:0051091 GO:0048661 GO:0042102 GO:0045630 GO:0045944 GO:0045893 GO:0045727 GO:0051971 GO:0042517 GO:0042981 GO:0042127 GO:0008360 GO:0045188 GO:0010574 GO:0043200 GO:0046677 GO:0010996 GO:0031000 GO:0051592 GO:0009409 GO:0042493 GO:0051602 GO:0009408 GO:0032868 GO:0031667 GO:0032494 GO:0009611 GO:0042110 GO:0072540 GO:0042060
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR003574 IPR003573
PANTHER	PTHR11457
Pfam	PF00489
PIRSF	PIRSF001935
PRINTS	PR00433 PR00434
SMART	SM00126
SUPFAM	SSF47266
PROSITE	PS00254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002675	positive regulation of acute inflammatory response	PMID:24223643^[1]	ECO:0000314			P		Figure 4 shows that inhibition of IL-6 using MR16-1 greatly increased the recovery time of spinal cord injury mice because of a reduced inflammatory response which is normally positively regulated by IL-6.	complete CACAO 9470
	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:24449804	ECO:0000314			P		Figure 4 shows the dilation of aortic tissue in mice with increased concentrations of IL-6 due to the break down of collagen.	complete CACAO 9472
	GO:0009409	response to cold	PMID:24416310^[2]	ECO:0000314			P		Figure 3C shows a great increase in UCP1 protein because of IL-6 when under cold exposure conditions.	complete CACAO 9474
	GO:0042493	response to drug	PMID:22047130^[3]	ECO:0000314			P		Figure 2C treatment with diazoxide decreases release of IL-6 in a dose dependent manner	complete CACAO 3828
	GO:0008518	reduced folate carrier activity	PMID:22546471^[4]	ECO:0000314			F		Interleukin-6 "reduced SLC19A1 [a reduced folate carrier] expression in mouse synoviocytes."	complete CACAO 5818
involved_in	GO:0014015	positive regulation of gliogenesis	PMID:26134658^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_agent:(CL:0000129) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0045380	positive regulation of interleukin-17 biosynthetic process	PMID:25362566^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	PMID:11159963^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P18893)	Seeded From UniProt	complete
involved_in	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	PMID:11159963^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0045779)	Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	PMID:11159963^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:16330325^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0070102)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16330325^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9EQ21) part_of:(GO:0070102)	Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:16330325^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070091	glucagon secretion	PMID:18719127^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:18719127^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	PMID:16990136^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090091	positive regulation of extracellular matrix disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071864	positive regulation of cell proliferation in bone marrow	PMID:21048959^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95560 MGI:MGI:97799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	PMID:19955433^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	PMID:19955433^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23610142^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:21606371^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:19047410^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070102	interleukin-6-mediated signaling pathway	PMID:1312474^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:11275690^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:11275690^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:11275690^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051971	positive regulation of transmission of nerve impulse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051024	positive regulation of immunoglobulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050871	positive regulation of B cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:11275690^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:11275690^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048635	negative regulation of muscle organ development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046888	negative regulation of hormone secretion	PMID:7867561^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	PMID:18056981^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19666510^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96542 MGI:MGI:96543	P	has_regulation_target:(MGI:MGI:107364)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:1373998^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045837	negative regulation of membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045630	positive regulation of T-helper 2 cell differentiation	PMID:12594267^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045454	cell redox homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045079	negative regulation of chemokine biosynthetic process	PMID:12925700^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045079	negative regulation of chemokine biosynthetic process	PMID:12925700^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:11275690^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042832	defense response to protozoan	PMID:17109471^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:24332041^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2385165	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:18056981^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042110	T cell activation	PMID:18792410^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21072211^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:7959007^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96536 MGI:MGI:96787	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010574	regulation of vascular endothelial growth factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:11275690^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17755)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:19404405^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008360	regulation of cell shape	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	P		Seeded From UniProt	complete
part_of	GO:0005896	interleukin-6 receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25084278^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23892723^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23460747^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23395675^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19139201^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18559975^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18261938^[37]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17693256^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17277142^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16275384^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16236719^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15843532^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1577194^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15692051^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15292196^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15240714^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:14764707^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12855817^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11894098^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11016935^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000581)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10549626^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	C		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	PMID:1312474^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	F		Seeded From UniProt	complete
contributes_to	GO:0005138	interleukin-6 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:23395675^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1373998^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12925700^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2901	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002675	positive regulation of acute inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002384	hepatic immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002262	myeloid cell homeostasis	PMID:24357729^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001781	neutrophil apoptotic process	PMID:12925700^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001781	neutrophil apoptotic process	PMID:12925700^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001781	neutrophil apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05231	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:1990646	cellular response to prolactin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0051971	positive regulation of transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0048635	negative regulation of muscle organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045837	negative regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0031294	lymphocyte costimulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0010996	response to auditory stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	C		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	F		Seeded From UniProt	complete
involved_in	GO:0002526	acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20607 ensembl:ENSRNOP00000013732	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030474	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574 InterPro:IPR030474	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003574 InterPro:IPR030474	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0011	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Murakami, T et al. (2013) Anti-interleukin-6 receptor antibody reduces neuropathic pain following spinal cord injury in mice. Exp Ther Med 6 1194-1198 PubMed GONUTS page
↑ Knudsen, JG et al. (2014) Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. PLoS ONE 9 e84910 PubMed GONUTS page
↑ Virgili, N et al. (2011) Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. J Neuroinflammation 8 149 PubMed GONUTS page
↑ Hashizume, M et al. (2012) Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Arthritis Res. Ther. 14 R96 PubMed GONUTS page
↑ Woodbury, ME et al. (2015) miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J. Neurosci. 35 9764-81 PubMed GONUTS page
↑ Zhang, R et al. (2015) miR26a modulates Th17/T reg balance in the EAE model of multiple sclerosis by targeting IL6. Neuromolecular Med. 17 24-34 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Balto, K et al. (2001) Interleukin-6 deficiency increases inflammatory bone destruction. Infect. Immun. 69 744-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wang, RH et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 399-409 PubMed GONUTS page
↑ ^9.0 ^9.1 Ellingsgaard, H et al. (2008) Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc. Natl. Acad. Sci. U.S.A. 105 13163-8 PubMed GONUTS page
↑ Ivanov, II et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 1121-33 PubMed GONUTS page
↑ Pirih, FQ et al. (2010) Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS ONE 5 e13657 PubMed GONUTS page
↑ ^12.0 ^12.1 Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page
↑ Fukasaka, M et al. (2013) Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J. Immunol. 190 5702-11 PubMed GONUTS page
↑ Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
↑ Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^17.0 ^17.1 Fiorillo, MT et al. (1992) Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction. Eur. J. Immunol. 22 799-804 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Melnick, M et al. (2001) Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs (Print) 168 233-45 PubMed GONUTS page
↑ Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page
↑ ^20.0 ^20.1 Baltgalvis, KA et al. (2008) Interleukin-6 and cachexia in ApcMin/+ mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R393-401 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ ^22.0 ^22.1 Itoh, Y et al. (1992) Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin. Exp. Immunol. 88 356-9 PubMed GONUTS page
↑ Kusam, S et al. (2003) Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J. Immunol. 170 2435-41 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 McLoughlin, RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112 598-607 PubMed GONUTS page
↑ Wu, W et al. (2006) Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur. J. Immunol. 36 3238-47 PubMed GONUTS page
↑ Gao, S et al. (2013) NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell 24 725-37 PubMed GONUTS page
↑ van Hamburg, JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38 2573-86 PubMed GONUTS page
↑ Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page
↑ Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page
↑ Sônego, F et al. (2014) MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE 9 e103734 PubMed GONUTS page
↑ Yang, S et al. (2013) Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat. Immunol. 14 927-36 PubMed GONUTS page
↑ Poddar, D et al. (2013) An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J. Immunol. 190 3600-12 PubMed GONUTS page
↑ ^34.0 ^34.1 Zheng, Y et al. (2013) Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation. Immunity 38 285-95 PubMed GONUTS page
↑ Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ Novitskiy, SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112 1822-31 PubMed GONUTS page
↑ Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page
↑ Lee, NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130 456-69 PubMed GONUTS page
↑ Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page
↑ Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page
↑ Negishi, H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc. Natl. Acad. Sci. U.S.A. 102 15989-94 PubMed GONUTS page
↑ Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page
↑ De, M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev. Biol. 151 297-305 PubMed GONUTS page
↑ Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page
↑ Lye, E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279 40653-8 PubMed GONUTS page
↑ McKee, AS & Pearce, EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J. Immunol. 173 1224-31 PubMed GONUTS page
↑ Sakurai, D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J. Immunol. 172 2374-81 PubMed GONUTS page
↑ Yamamoto, M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 640-3 PubMed GONUTS page
↑ Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page
↑ Solle, M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276 125-32 PubMed GONUTS page
↑ Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page
↑ Gardenghi, S et al. (2014) Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood 123 1137-45 PubMed GONUTS page

[PMID:24223643-1] Murakami, T et al. (2013) Anti-interleukin-6 receptor antibody reduces neuropathic pain following spinal cord injury in mice. Exp Ther Med 6 1194-1198 PubMed GONUTS page

[PMID:24416310-2] Knudsen, JG et al. (2014) Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. PLoS ONE 9 e84910 PubMed GONUTS page

[PMID:22047130-3] Virgili, N et al. (2011) Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. J Neuroinflammation 8 149 PubMed GONUTS page

[PMID:22546471-4] Hashizume, M et al. (2012) Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Arthritis Res. Ther. 14 R96 PubMed GONUTS page

[PMID:26134658-5] Woodbury, ME et al. (2015) miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J. Neurosci. 35 9764-81 PubMed GONUTS page

[PMID:25362566-6] Zhang, R et al. (2015) miR26a modulates Th17/T reg balance in the EAE model of multiple sclerosis by targeting IL6. Neuromolecular Med. 17 24-34 PubMed GONUTS page

[PMID:11159963-7] 7.0 ^7.1 ^7.2 Balto, K et al. (2001) Interleukin-6 deficiency increases inflammatory bone destruction. Infect. Immun. 69 744-50 PubMed GONUTS page

[PMID:16330325-8] 8.0 ^8.1 ^8.2 Wang, RH et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 399-409 PubMed GONUTS page

[PMID:18719127-9] 9.0 ^9.1 Ellingsgaard, H et al. (2008) Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc. Natl. Acad. Sci. U.S.A. 105 13163-8 PubMed GONUTS page

[PMID:16990136-10] Ivanov, II et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 1121-33 PubMed GONUTS page

[PMID:21048959-11] Pirih, FQ et al. (2010) Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS ONE 5 e13657 PubMed GONUTS page

[PMID:19955433-12] 12.0 ^12.1 Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page

[PMID:23610142-13] Fukasaka, M et al. (2013) Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J. Immunol. 190 5702-11 PubMed GONUTS page

[PMID:21606371-14] Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page

[PMID:19047410-15] Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

[PMID:23776175-16] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:1312474-17] 17.0 ^17.1 Fiorillo, MT et al. (1992) Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction. Eur. J. Immunol. 22 799-804 PubMed GONUTS page

[PMID:11275690-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Melnick, M et al. (2001) Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs (Print) 168 233-45 PubMed GONUTS page

[PMID:7867561-19] Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page

[PMID:18056981-20] 20.0 ^20.1 Baltgalvis, KA et al. (2008) Interleukin-6 and cachexia in ApcMin/+ mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R393-401 PubMed GONUTS page

[PMID:19666510-21] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:1373998-22] 22.0 ^22.1 Itoh, Y et al. (1992) Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin. Exp. Immunol. 88 356-9 PubMed GONUTS page

[PMID:12594267-23] Kusam, S et al. (2003) Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J. Immunol. 170 2435-41 PubMed GONUTS page

[PMID:12925700-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 McLoughlin, RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112 598-607 PubMed GONUTS page

[PMID:17109471-25] Wu, W et al. (2006) Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur. J. Immunol. 36 3238-47 PubMed GONUTS page

[PMID:24332041-26] Gao, S et al. (2013) NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell 24 725-37 PubMed GONUTS page

[PMID:18792410-27] van Hamburg, JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur. J. Immunol. 38 2573-86 PubMed GONUTS page

[PMID:21072211-28] Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page

[PMID:7959007-29] Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page

[PMID:19404405-30] Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page

[PMID:25084278-31] Sônego, F et al. (2014) MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS ONE 9 e103734 PubMed GONUTS page

[PMID:23892723-32] Yang, S et al. (2013) Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat. Immunol. 14 927-36 PubMed GONUTS page

[PMID:23460747-33] Poddar, D et al. (2013) An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J. Immunol. 190 3600-12 PubMed GONUTS page

[PMID:23395675-34] 34.0 ^34.1 Zheng, Y et al. (2013) Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation. Immunity 38 285-95 PubMed GONUTS page

[PMID:19139201-35] Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page

[PMID:18559975-36] Novitskiy, SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112 1822-31 PubMed GONUTS page

[PMID:18261938-37] Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page

[PMID:17693256-38] Lee, NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130 456-69 PubMed GONUTS page

[PMID:17277142-39] Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page

[PMID:16275384-40] Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page

[PMID:16236719-41] Negishi, H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc. Natl. Acad. Sci. U.S.A. 102 15989-94 PubMed GONUTS page

[PMID:15843532-42] Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page

[PMID:1577194-43] De, M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev. Biol. 151 297-305 PubMed GONUTS page

[PMID:15692051-44] Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page

[PMID:15292196-45] Lye, E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279 40653-8 PubMed GONUTS page

[PMID:15240714-46] McKee, AS & Pearce, EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J. Immunol. 173 1224-31 PubMed GONUTS page

[PMID:14764707-47] Sakurai, D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J. Immunol. 172 2374-81 PubMed GONUTS page

[PMID:12855817-48] Yamamoto, M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 640-3 PubMed GONUTS page

[PMID:11894098-49] Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page

[PMID:11016935-50] Solle, M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276 125-32 PubMed GONUTS page

[PMID:10549626-51] Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page

[PMID:24357729-52] Gardenghi, S et al. (2014) Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus. Blood 123 1137-45 PubMed GONUTS page

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