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PMID:1373998
| Citation |
Itoh, Y, Maruyama, N, Kitamura, M, Shirasawa, T, Shigemoto, K and Koike, T (1992) Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin. Exp. Immunol. 88:356-9 |
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| Abstract |
The effect of Lps locus and IL-6 on the production of SU (previously termed gp70), a mouse endogenous retroviral gene product, was studied. Back-cross studies using the progeny between (NZB x C3H/HeJ)F1 and C3H/HeJ mice indicate that the basal level of SU is not associated with the Lps locus on chromosome 4. Lipopolysaccharide (LPS) mitogen response-negative mice did not show the enhancement of serum SU production after LPS injection. Spleen cells from LPS-mitogen response-positive but not from negative mice showed increase of IL-6 synthesis in the presence of LPS. Since IL-6 may be involved in the production of serum SU, we tested the effect of IL-6 in a primary hepatocyte culture system. SU production was clearly enhanced in the presence of recombinant IL-6, indicating that IL-6 induced by LPS can enhance the expression of retroviral genome. |
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| Keywords |
Acute-Phase Proteins/biosynthesis; Animals; Cells, Cultured; Crosses, Genetic; Female; Interleukin-6/biosynthesis; Interleukin-6/pharmacology; Lipopolysaccharides; Liver/metabolism; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Inbred NZB; Recombinant Proteins/pharmacology; Retroviridae Proteins, Oncogenic/biosynthesis; Transcription, Genetic/drug effects; Viral Envelope Proteins/biosynthesis |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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