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PMID:22546471
| Citation |
Hashizume, M, Yoshida, H, Tanaka, K, Suzuki, M, Matsumoto, I, Sumida, T and Mihara, M (2012) Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Arthritis Res. Ther. 14:R96 |
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| Abstract |
Methotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that SLC19A1 is associated with the efficacy of MTX. We here examined the relationship between the efficacy of MTX and the expression of SLC19A1 in glucose 6-phosphate isomerase (GPI)-induced arthritis. We found that interleukin-6 (IL-6) regulated the expression of SLC19A1, so we studied the effect of a combination of MTX and anti-mouse IL-6 receptor antibody (MR16-1). |
| Links |
PubMed PMC3446470 Online version:10.1186/ar3821 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008518: reduced folate carrier activity |
ECO:0000314: |
F |
Interleukin-6 "reduced SLC19A1 [a reduced folate carrier] expression in mouse synoviocytes." |
complete | ||||
See also
References
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