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MOUSE:FOXP2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Foxp2 | |
| Protein Name(s) | Forkhead box protein P2 | |
| External Links | ||
| UniProt | P58463 | |
| EMBL | AF339106 AY079003 AK082361 BC058960 BC062926 | |
| CCDS | CCDS19918.1 CCDS71726.1 | |
| RefSeq | NP_001273536.1 NP_444472.2 NP_997600.1 | |
| UniGene | Mm.332919 | |
| ProteinModelPortal | P58463 | |
| SMR | P58463 | |
| BioGrid | 227578 | |
| PhosphoSite | P58463 | |
| PRIDE | P58463 | |
| Ensembl | ENSMUST00000031545 ENSMUST00000115472 ENSMUST00000115477 | |
| GeneID | 114142 | |
| KEGG | mmu:114142 | |
| UCSC | uc009ayy.1 uc012eie.1 | |
| CTD | 93986 | |
| MGI | MGI:2148705 | |
| eggNOG | COG5025 | |
| GeneTree | ENSGT00750000117475 | |
| HOGENOM | HOG000092089 | |
| HOVERGEN | HBG051657 | |
| InParanoid | P58463 | |
| KO | K09409 | |
| OrthoDB | EOG7M6D7G | |
| PhylomeDB | P58463 | |
| TreeFam | TF326978 | |
| ChiTaRS | Foxp2 | |
| NextBio | 368137 | |
| PRO | PR:P58463 | |
| Proteomes | UP000000589 | |
| Bgee | P58463 | |
| CleanEx | MM_FOXP2 | |
| ExpressionAtlas | P58463 | |
| Genevestigator | P58463 | |
| GO | GO:0005634 GO:0003677 GO:0046872 GO:0046982 GO:0042803 GO:0000978 GO:0001078 GO:0003700 GO:0043010 GO:0021757 GO:0021549 GO:0021987 GO:0040007 GO:0048286 GO:0030324 GO:0000122 GO:0045892 GO:0050679 GO:0060501 GO:0002053 GO:0009791 GO:0021758 GO:0060013 GO:0007519 GO:0048745 GO:0042297 | |
| Gene3D | 1.10.10.10 | |
| InterPro | IPR001766 IPR018122 IPR011991 IPR015880 | |
| Pfam | PF00250 | |
| PRINTS | PR00053 | |
| SMART | SM00339 SM00355 | |
| PROSITE | PS00658 PS50039 PS00028 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:22287) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021758 |
putamen development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021757 |
caudate nucleus development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060501 |
positive regulation of epithelial cell proliferation involved in lung morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
regulates_o_occurs_in:(EMAPA:16728) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060013 |
righting reflex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3723630 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
occurs_in:(EMAPA:16728) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048745 |
smooth muscle tissue development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
results_in_development_of:(EMAPA:18860)|results_in_development_of:(EMAPA:16833) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048286 |
lung alveolus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3584266 |
P |
results_in_development_of:(EMAPA:16728)|results_in_development_of:(EMAPA:32692) |
Seeded From UniProt |
complete | |
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0042297 |
vocal learning |
ECO:0000315 |
P |
Disruption of both copies of the Foxp2 gene caused severe motor impairment, premature death, and an absence of ultrasonic vocalizations that are elicited when pups are removed from their mothers. Figure 1b shows a southern blot analysis showing the alteration of the mutant foxp2 allele. |
complete | |||||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043010 |
camera-type eye development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3723630 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042297 |
vocal learning |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3584266 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030324 |
lung development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
results_in_development_of:(EMAPA:16728) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0021549 |
cerebellum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3723630 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0021549 |
cerebellum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3584266 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0009791 |
post-embryonic development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3723630 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007519 |
skeletal muscle tissue development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
results_in_development_of:(EMAPA:18860)|results_in_development_of:(EMAPA:16833) |
Seeded From UniProt |
complete | |
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1914004 |
P |
occurs_in:(EMAPA:16728) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021758 |
putamen development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021757 |
caudate nucleus development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O15409 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098582 |
innate vocalization behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P0CF24 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P0CF24 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033574 |
response to testosterone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P0CF24 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030900 |
forebrain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P0CF24 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Li, S et al. (2004) Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol. Cell. Biol. 24 809-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Shu, W et al. (2007) Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development 134 1991-2000 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 French, CA et al. (2007) Generation of mice with a conditional Foxp2 null allele. Genesis 45 440-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Shu, W et al. (2005) Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc. Natl. Acad. Sci. U.S.A. 102 9643-8 PubMed GONUTS page
- ↑ Shu, W et al. (2001) Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J. Biol. Chem. 276 27488-97 PubMed GONUTS page
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- GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
- GO:0002053 ! positive regulation of mesenchymal cell proliferation
- GO:0050679 ! positive regulation of epithelial cell proliferation
- GO:0009791 ! post-embryonic development
- GO:0046982 ! protein heterodimerization activity
- GO:0042803 ! protein homodimerization activity
- GO:0021758 ! putamen development
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