User:Deasterling

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	HUMAN:COGA1	2014-01-30 07:35:05 CST	GO:0051894 positive regulation of focal adhesion assembly (P)	PMID:24466237	ECO:0000314 direct assay evidence used in manual assertion	Figure 2A displays that over expression of Collagen XVI increases interaction with integrin-linked kinase/kindlin-1 only at the focal adhesions.	challenge
unacceptable	HUMAN:CO3A1	2014-01-30 09:14:55 CST	GO:0032966 negative regulation of collagen biosynthetic process (P)	PMID:24288677	ECO:0000314 direct assay evidence used in manual assertion	Figure 5 depicts through immunofluorescence, nAG protein expression in human fibroblast cells has an inhibitory effect on the expression of collagen I and III.	challenge
unacceptable	HUMAN:ELN	2014-01-30 10:13:54 CST	GO:0060311 negative regulation of elastin catabolic process (P)	PMID:24358135	ECO:0000314 direct assay evidence used in manual assertion	Figure 9 shows where the boundaries of the elastic lamellae layers are compromised and loose amorphous elastin has been exposed as a result of elastase digestion.	challenge
updatedbyinstructor	HUMAN:MFAP2	2014-01-30 10:36:58 CST	GO:0001527 microfibril (C)	PMID:24353434	ECO:0000314 direct assay evidence used in manual assertion	Figure 3	challenge
unacceptable	HUMAN:CO3A1	2014-01-30 11:02:39 CST	GO:0032966 negative regulation of collagen biosynthetic process (P)	PMID:24288677	ECO:0000314 direct assay evidence used in manual assertion	Figure 4 displays a western blot assay showing collagen III expression in untreated control fibroblasts and control fibroblasts treated with TGF-β1. With TGF-β1 treatment, there was also decreased collagen III expression in transfected fibroblasts. This shows that the inhibitory effect of nAG is dominant over the TGF-β1 effect.	challenge
updatedbyinstructor	HUMAN:COR1B	2014-02-02 09:19:06 CST	GO:0035767 endothelial cell chemotaxis (P)	PMID:23667561	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 5	challenge
unacceptable	HUMAN:COR1B	2014-02-02 09:57:03 CST	GO:0035767 endothelial cell chemotaxis (P)	PMID:23667561	ECO:0000314 direct assay evidence used in manual assertion	Rac1 plays a role in S1P-induced redistribution of coronin 1B and cortactin to cell periphery as well as chemotaxis of human pulmonary artery endothelial cells. (Figure 7)	challenge
unacceptable	HUMAN:RBL1	2014-02-02 17:27:19 CST	GO:0006611 protein export from nucleus (P)	PMID:24302570	ECO:0000314 direct assay evidence used in manual assertion	Figure 1:Phosphorylation of retinoblastoma proteins by up-regulation of cyclin-dependent kinase 4 triggers its cytoplasmic translocation from the nucleus in human skeletal muscle myotubes.	challenge

acceptable:0
unacceptable:5
requires_changes:0
flagged:0

Annotations challenged by Deasterling

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Kfree, Team Bfast Taco	MOUSE:ACHB4	GO:0051971 - positive regulation of transmission of nerve impulse (P)	PMID:12606764	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 5 fixed by Kfree
unacceptable	Cford, Team What the Fox Says	HUMAN:PML	GO:0051607 - defense response to virus (P)	PMID:24407287	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
unacceptable	Wtrimble, Team Pnut Butter Squares	MOUSE:MERTK	GO:0002834 - regulation of response to tumor cell (P)	PMID:23867499	ECO:0000316 genetic interaction evidence used in manual assertion	challenge	C: 3
unacceptable	Aborel, Team Schmowzow	HUMAN:IL1RA	GO:0002439 - chronic inflammatory response to antigenic stimulus (P)	PMID:24383930	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
unacceptable	Asigurdsson, Team On a Boat	MOUSE:BMP2	GO:0035630 - bone mineralization involved in bone maturation (P)	PMID:15039429	ECO:0000316 genetic interaction evidence used in manual assertion	challenge	C: 3
unacceptable	Tnguyen2, Team Food Rewards	HUMAN:AIM2	GO:0002218 - activation of innate immune response (P)	PMID:24325587	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Deasterling

What do the icons mean in the status column?