User:Tnguyen2

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:AIM2	2014-01-30 17:42:20 CST	GO:0002218 activation of innate immune response (P)	PMID:21057088	ECO:0000314 direct assay evidence used in manual assertion	Figure 1A: Unlike wild-type splenic cells, Aim2-null splenic cells had higher basal levels of STAT1, p202, p-STAT1, & viperin, an IFN-inducible protein.	challenge
updatedbyinstructor	?	2014-01-30 23:10:30 CST	GO:0043032 positive regulation of macrophage activation (Figure 6C: Analysis of RT-PCR showed that enforced expression of Ifi204 favors M-CSF-dependent macrophage differentiation in in FD-Fms cells.)	PMID:16244109	IDA: Inferred from Direct Assay		challenge
unacceptable	HUMAN:AIM2	2014-01-30 23:32:54 CST	GO:0002218 activation of innate immune response (P)	PMID:24325587	ECO:0000314 direct assay evidence used in manual assertion	Table 5: High HBV load led to the increase in AIM2 expression which in turn resulted in a positive correlation with caspase-1 and IL-1β observed.	challenge
unacceptable	HUMAN:NALP3	2014-01-31 00:05:34 CST	GO:0072559 NLRP3 inflammasome complex (C)	PMID:22147977	ECO:0000314 direct assay evidence used in manual assertion	Figure 3: LPS upregulation of mRNA expression of Nalp3 led to an increase in caspase, a protease known to play a role in inflammation.	challenge
unacceptable	HUMAN:INAR1	2014-01-31 00:54:18 CST	GO:0045351 type I interferon biosynthetic process (P)	PMID:24409099	ECO:0000314 direct assay evidence used in manual assertion	Figures 1B-E: The majority of changes to regulation of genes were dependent on type I IFN and not PRR stimulation. Thus type I IFN can be concluded to be the main variable for which maturation and metabolic shift to glycolysis after poly IC stimulation relies on.	challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Tnguyen2

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Asigurdsson, Team On a Boat	RAT:ASIC2	GO:0005261 - monoatomic cation channel activity (F)	PMID:8631835	ECO:0000266 sequence orthology evidence used in manual assertion	challenge	C: 3
updatedbyinstructor	Kyoung, Team Pnut Butter Squares	HUMAN:BRCA1	GO:0033147 - negative regulation of intracellular estrogen receptor signaling pathway (P)	PMID:17505062	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3 fixed by Grevever
unacceptable	Astephens2, Team Bacon Pancakes	HUMAN:FADD		PMID:9582077	ECO:0000247 sequence alignment evidence used in manual assertion	challenge	C: 2
unacceptable	Astephens2, Team Bacon Pancakes	HUMAN:SHBG	GO:0007285 - primary spermatocyte growth (P)	PMID:3569533	ECO:0000255 match to sequence model evidence used in manual assertion	challenge	C: 2
unacceptable	Csobelman, Team Lobster Soul	MOUSE:P53	GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (P)	PMID:12952892	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3
unacceptable	Cbrandao, Team Schmowzow	BACSU:COTH	GO:0030435 - sporulation resulting in formation of a cellular spore (P)	PMID:24355926	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Tnguyen2

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