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HUMAN:INAR1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFNAR1 (synonyms: IFNAR)
Protein Name(s) Interferon alpha/beta receptor 1

IFN-R-1 IFN-alpha/beta receptor 1 Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 CRF2-1 Type I interferon receptor 1

External Links
UniProt P17181
EMBL J03171
X60459
AK298051
AK312631
AK222770
AK222812
AY654286
AF039907
AP000296
AP000297
AP000298
CH471079
CH471079
BC002590
BC021825
CCDS CCDS13624.1
PIR A32694
S41602
RefSeq NP_000620.2
XP_005261021.1
UniGene Hs.529400
PDB 3S98
3SE3
3SE4
4PO6
PDBsum 3S98
3SE3
3SE4
4PO6
ProteinModelPortal P17181
SMR P17181
BioGrid 109676
DIP DIP-57N
IntAct P17181
MINT MINT-107953
STRING 9606.ENSP00000270139
ChEMBL CHEMBL2364170
DrugBank DB00034
DB00105
DB00011
DB00018
DB00069
DB00060
DB00068
DB05258
DB00008
DB00022
GuidetoPHARMACOLOGY 1723
PhosphoSite P17181
DMDM 90110827
MaxQB P17181
PaxDb P17181
PRIDE P17181
DNASU 3454
Ensembl ENST00000270139
GeneID 3454
KEGG hsa:3454
UCSC uc002yrn.3
CTD 3454
GeneCards GC21P034696
HGNC HGNC:5432
HPA HPA018015
MIM 107450
neXtProt NX_P17181
PharmGKB PA29670
eggNOG NOG43815
GeneTree ENSGT00530000063449
HOVERGEN HBG052126
InParanoid P17181
KO K05130
OMA VYCVKAR
OrthoDB EOG73FQMD
PhylomeDB P17181
Reactome REACT_25162
REACT_25216
SignaLink P17181
ChiTaRS IFNAR1
EvolutionaryTrace P17181
GeneWiki IFNAR1
GenomeRNAi 3454
NextBio 13606
PRO PR:P17181
Proteomes UP000005640
Bgee P17181
CleanEx HS_IFNAR1
ExpressionAtlas P17181
Genevestigator P17181
GO GO:0005887
GO:0005886
GO:0004905
GO:0007166
GO:0019221
GO:0051607
GO:0007259
GO:0032729
GO:0050718
GO:0060338
GO:0009615
GO:0042110
GO:0045351
GO:0060337
Gene3D 2.60.40.10
InterPro IPR003961
IPR013783
IPR016669
IPR015373
Pfam PF09294
PF01108
PIRSF PIRSF016567
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060337

type I interferon signaling pathway

PMID:7665574[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004905

type I interferon receptor activity

PMID:7665574[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:14532120[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019962

type I interferon binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P33896

F

Seeded From UniProt

complete

involved_in

GO:0035457

cellular response to interferon-alpha

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P33896

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P33896

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3605069
PANTHER:PTN000466212

P

Seeded From UniProt

complete

GO:0045351

type I interferon biosynthetic process

PMID:24409099[4]

ECO:0000314

P

Figures 1B-E: The majority of changes to regulation of genes were dependent on type I IFN and not PRR stimulation. Thus type I IFN can be concluded to be the main variable for which maturation and metabolic shift to glycolysis after poly IC stimulation relies on.

complete
CACAO 9359

part_of

GO:0005886

plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000466212
RGD:620138

C

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000466212
ZFIN:ZDB-GENE-070905-4

F

Seeded From UniProt

complete

enables

GO:0004904

interferon receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016669

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016669

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:2153461[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007259

receptor signaling pathway via JAK-STAT

PMID:7665574[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8181059[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-997314
Reactome:R-HSA-997311
Reactome:R-HSA-997309
Reactome:R-HSA-909732
Reactome:R-HSA-909730
Reactome:R-HSA-909729
Reactome:R-HSA-909726
Reactome:R-HSA-909724
Reactome:R-HSA-909722
Reactome:R-HSA-909719
Reactome:R-HSA-909718

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0152

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Domanski, P et al. (1995) Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J. Biol. Chem. 270 21606-11 PubMed GONUTS page
  2. ↑ Kumar, KG et al. (2003) SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 22 5480-90 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Pantel, A et al. (2014) Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 12 e1001759 PubMed GONUTS page
  5. ↑ Uzé, G et al. (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60 225-34 PubMed GONUTS page
  6. ↑ Novick, D et al. (1994) The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77 391-400 PubMed GONUTS page
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