HUMAN:AIM2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AIM2
Protein Name(s)	Interferon-inducible protein AIM2 Absent in melanoma 2
External Links
UniProt	O14862
EMBL	AF024714 AK292042 AL359753 BC010940
CCDS	CCDS1181.1
RefSeq	NP_004824.1
UniGene	Hs.733411
PDB	3RN2 3RN5 3VD8 4O7Q
PDBsum	3RN2 3RN5 3VD8 4O7Q
ProteinModelPortal	O14862
SMR	O14862
DIP	DIP-59741N
IntAct	O14862
STRING	9606.ENSP00000357112
PhosphoSite	O14862
MaxQB	O14862
PaxDb	O14862
PRIDE	O14862
Ensembl	ENST00000368130
GeneID	9447
KEGG	hsa:9447
UCSC	uc001ftj.1
CTD	9447
GeneCards	GC01M159032
HGNC	HGNC:357
HPA	HPA031365
MIM	604578
neXtProt	NX_O14862
PharmGKB	PA24651
eggNOG	NOG132015
GeneTree	ENSGT00390000013296
HOGENOM	HOG000033871
HOVERGEN	HBG006122
InParanoid	O14862
KO	K12966
OMA	FQKLNYM
OrthoDB	EOG78H3TT
PhylomeDB	O14862
TreeFam	TF337385
Reactome	REACT_75777
GeneWiki	AIM2
GenomeRNAi	9447
NextBio	35388
PRO	PR:O14862
Proteomes	UP000005640
Bgee	O14862
CleanEx	HS_AIM2
ExpressionAtlas	O14862
Genevestigator	O14862
GO	GO:0097169 GO:0005737 GO:0005829 GO:0005634 GO:0003690 GO:0042802 GO:0002218 GO:0006915 GO:0035690 GO:0035458 GO:0006955 GO:0006954 GO:0045087 GO:0050702 GO:0032088 GO:0035872 GO:2001056 GO:0002230 GO:0032731 GO:0050718 GO:0051092 GO:0032461 GO:0070269 GO:0033209
Gene3D	1.10.533.10 2.40.50.140
InterPro	IPR004020 IPR011029 IPR004021 IPR012340
Pfam	PF02760 PF02758
SUPFAM	SSF47986
PROSITE	PS50824 PS50834

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0002218	activation of innate immune response	PMID:21057088^[1]	ECO:0000314			P	Figure 1A: Unlike wild-type splenic cells, Aim2-null splenic cells had higher basal levels of STAT1, p202, p-STAT1, & viperin, an IFN-inducible protein.	complete CACAO 9338
part_of	GO:0005737	cytoplasm	PMID:24531343^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
	GO:0002218	activation of innate immune response	PMID:24325587^[3]	ECO:0000314			P	Table 5: High HBV load led to the increase in AIM2 expression which in turn resulted in a positive correlation with caspase-1 and IL-1β observed.	complete CACAO 9357
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:19158675^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:19158675^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:16432157^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:19158675^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:16432157^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:19158675^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VJ1	P	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:19158675^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:19158676^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:19158679^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:19158679^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24630722^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14862	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19158676^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14862	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	C	Seeded From UniProt	complete
involved_in	GO:0070269	pyroptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	F	Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	C	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	F	Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VJ1 ensembl:ENSMUSP00000119465	P	Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040205	P	Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040205	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:9242382^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-844619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Panchanathan, R et al. (2010) Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J. Immunol. 185 7385-93 PubMed GONUTS page
↑ Khare, S et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat. Immunol. 15 343-53 PubMed GONUTS page
↑ Du, W et al. (2013) Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis. J Inflamm (Lond) 10 37 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Fernandes-Alnemri, T et al. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458 509-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hornung, V et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 514-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Chen, IF et al. (2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol. Cancer Ther. 5 1-7 PubMed GONUTS page
↑ Lu, A et al. (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156 1193-206 PubMed GONUTS page
↑ DeYoung, KL et al. (1997) Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene 15 453-7 PubMed GONUTS page

[PMID:21057088-1] Panchanathan, R et al. (2010) Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. J. Immunol. 185 7385-93 PubMed GONUTS page

[PMID:24531343-2] Khare, S et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat. Immunol. 15 343-53 PubMed GONUTS page

[PMID:24325587-3] Du, W et al. (2013) Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis. J Inflamm (Lond) 10 37 PubMed GONUTS page

[PMID:19158679-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page

[PMID:19158676-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Fernandes-Alnemri, T et al. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458 509-13 PubMed GONUTS page

[PMID:19158675-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hornung, V et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 514-8 PubMed GONUTS page

[PMID:16432157-7] 7.0 ^7.1 Chen, IF et al. (2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol. Cancer Ther. 5 1-7 PubMed GONUTS page

[PMID:24630722-8] Lu, A et al. (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156 1193-206 PubMed GONUTS page

[PMID:9242382-9] DeYoung, KL et al. (1997) Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. Oncogene 15 453-7 PubMed GONUTS page

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HUMAN:AIM2

Contents

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