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PMID:24325587
| Citation |
Du, W, Zhen, J, Zheng, Z, Ma, S and Chen, S (2013) Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis. J Inflamm (Lond) 10:37 |
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| Abstract |
Innate immunity is the first line of defense against invasive microbial infection, and AIM2 plays an important role in this process by sensing double-stranded DNA viruses. However, the role of AIM2 in regulating the immune response to viruses in vivo, especially in sensing hepatitis B virus (HBV), has not been examined. We hypothesized that the expression of AIM2 increases corresponding to HBV-mediated inflammation in patients with hepatitis B virus associated glomerulonephritis (HBV-GN), a condition which activates inflammatory mechanisms and causes renal damage. To test this hypothesis, we analyzed the expression of AIM2 in HBV-GN patients in relation to the inflammatory response to HBV infection. |
| Links |
PubMed Online version:10.1186/1476-9255-10-37 |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002218: activation of innate immune response |
ECO:0000314: |
P |
Table 5: High HBV load led to the increase in AIM2 expression which in turn resulted in a positive correlation with caspase-1 and IL-1β observed. |
complete | ||||
See also
References
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