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HUMAN:RBL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBL1
Protein Name(s) Retinoblastoma-like protein 1

107 kDa retinoblastoma-associated protein p107 pRb1

External Links
UniProt P28749
EMBL L14812
AK290380
AL136172
AL365505
AL391114
AL365505
AL136172
AL391114
AL391114
AL136172
AL365505
AL365505
AL136172
AL391114
AL391114
AL136172
AL365505
AL136172
AL365505
AL391114
CH471077
BC032247
M74547
S78664
CCDS CCDS13289.1
CCDS13290.1
PIR A47319
RefSeq NP_002886.2
NP_899662.1
UniGene Hs.207745
PDB 1H28
PDBsum 1H28
ProteinModelPortal P28749
SMR P28749
BioGrid 111868
DIP DIP-148N
IntAct P28749
MINT MINT-1353484
STRING 9606.ENSP00000362768
PhosphoSite P28749
DMDM 90103515
MaxQB P28749
PaxDb P28749
PRIDE P28749
DNASU 5933
Ensembl ENST00000344359
ENST00000373664
GeneID 5933
KEGG hsa:5933
UCSC uc002xgi.3
uc002xgj.1
CTD 5933
GeneCards GC20M035624
H-InvDB HIX0040570
HGNC HGNC:9893
HPA HPA054962
HPA056525
MIM 116957
neXtProt NX_P28749
PharmGKB PA34257
eggNOG NOG296920
GeneTree ENSGT00530000063235
HOGENOM HOG000273892
HOVERGEN HBG017710
InParanoid P28749
KO K04681
OMA RRDMQPL
OrthoDB EOG7P5T04
PhylomeDB P28749
TreeFam TF105568
Reactome REACT_111214
REACT_120734
REACT_821
ChiTaRS RBL1
EvolutionaryTrace P28749
GeneWiki Retinoblastoma-like_protein_1
GenomeRNAi 5933
NextBio 23126
PRO PR:P28749
Proteomes UP000005640
Bgee P28749
CleanEx HS_RBL1
ExpressionAtlas P28749
Genevestigator P28749
GO GO:0005654
GO:0005634
GO:0005667
GO:0008134
GO:0016568
GO:0010467
GO:0000278
GO:0000122
GO:0045944
GO:0051726
GO:0043550
GO:0006367
GO:0006351
GO:0007179
GO:0016032
Gene3D 1.10.472.10
InterPro IPR013763
IPR002720
IPR002719
IPR015030
IPR028309
IPR024599
IPR028310
PANTHER PTHR13742
PTHR13742:SF20
Pfam PF11934
PF01858
PF01857
PF08934
SMART SM00385
SUPFAM SSF47954

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000773

negative regulation of cellular senescence

PMID:28595801[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000008)

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:8245034[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043550

regulation of lipid kinase activity

PMID:16286473[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q16254

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16360038[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14186

F

Seeded From UniProt

complete

Contributes to

GO:0006611

protein export from nucleus

PMID:24302570[5]

ECO:0000314

P

Figure 1:Phosphorylation of retinoblastoma proteins by up-regulation of cyclin-dependent kinase 4 triggers its cytoplasmic translocation from the nucleus in human skeletal muscle myotubes.

complete
CACAO 9459

involved_in

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
FB:FBgn0038390
MGI:MGI:97874
PANTHER:PTN000348425

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000348425
UniProtKB:Q9LKZ3

P

Seeded From UniProt

complete

involved_in

GO:0007346

regulation of mitotic cell cycle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000348425
UniProtKB:P06400

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103300
MGI:MGI:105085
MGI:MGI:97874
PANTHER:PTN000348425

C

Seeded From UniProt

complete

colocalizes_with

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
MGI:MGI:103300
MGI:MGI:105085
MGI:MGI:97874
PANTHER:PTN000348425
RGD:3540
UniProtKB:P06400
UniProtKB:Q08999
UniProtKB:Q9LKZ3
WB:WBGene00003020

C

Seeded From UniProt

complete

enables

GO:0001102

RNA polymerase II activating transcription factor binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97874
PANTHER:PTN000348425

F

Seeded From UniProt

complete

enables

GO:0001012

RNA polymerase II regulatory region DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
PANTHER:PTN000348425

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015799
PANTHER:PTN000348425
RGD:3541

C

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

PMID:25100735[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:25100735[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q64701
ensembl:ENSMUSP00000029170

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q64701
ensembl:ENSMUSP00000029170

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q64701
ensembl:ENSMUSP00000029170

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002719
InterPro:IPR002720

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028310

C

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028309

P

Seeded From UniProt

complete

involved_in

GO:0051302

regulation of cell division

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028310

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002719
InterPro:IPR002720
InterPro:IPR028309

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

Reactome:R-HSA-2173796

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8964525
Reactome:R-HSA-2127257
Reactome:R-HSA-1363314
Reactome:R-HSA-1363311
Reactome:R-HSA-1363274
Reactome:R-HSA-1227671
Reactome:R-HSA-1226095

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Wong, PF et al. (2017) Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells. Microvasc. Res. 114 26-33 PubMed GONUTS page
  2. ↑ Pahel, G et al. (1993) Structural and functional characterization of the HPV16 E7 protein expressed in bacteria. J. Biol. Chem. 268 26018-25 PubMed GONUTS page
  3. ↑ Los, AP et al. (2006) The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J. Biol. Chem. 281 858-66 PubMed GONUTS page
  4. ↑ 4.0 4.1 Rubin, SM et al. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123 1093-106 PubMed GONUTS page
  5. ↑ Araki, K et al. (2013) Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization. Elife 2 e01228 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Miles, WO et al. (2014) Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 33 2201-15 PubMed GONUTS page
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