HUMAN:COR1B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CORO1B
Protein Name(s)	Coronin-1B Coronin-2
External Links
UniProt	Q9BR76
EMBL	AK315399 CH471076 BC006449
CCDS	CCDS8164.1
RefSeq	NP_001018080.1 NP_065174.1
UniGene	Hs.6191
ProteinModelPortal	Q9BR76
SMR	Q9BR76
BioGrid	121425
IntAct	Q9BR76
MINT	MINT-5005556
STRING	9606.ENSP00000340211
PhosphoSite	Q9BR76
DMDM	21263481
MaxQB	Q9BR76
PaxDb	Q9BR76
PeptideAtlas	Q9BR76
PRIDE	Q9BR76
DNASU	57175
Ensembl	ENST00000341356 ENST00000393893
GeneID	57175
KEGG	hsa:57175
UCSC	uc001olk.1
CTD	57175
GeneCards	GC11M067205
HGNC	HGNC:2253
HPA	CAB017616
MIM	609849
neXtProt	NX_Q9BR76
PharmGKB	PA26769
eggNOG	COG2319
GeneTree	ENSGT00760000119195
HOGENOM	HOG000166356
HOVERGEN	HBG059978
InParanoid	Q9BR76
KO	K13886
OMA	QGERICR
OrthoDB	EOG7J70FB
PhylomeDB	Q9BR76
TreeFam	TF314280
SignaLink	Q9BR76
GenomeRNAi	57175
NextBio	63197
PRO	PR:Q9BR76
Proteomes	UP000005640
Bgee	Q9BR76
CleanEx	HS_CORO1B
ExpressionAtlas	Q9BR76
Genevestigator	Q9BR76
GO	GO:0015629 GO:0005884 GO:0031252 GO:0005737 GO:0070062 GO:0005925 GO:0030027 GO:0001725 GO:0051015 GO:0071933 GO:0042802 GO:0030036 GO:0090135 GO:0051017 GO:0016477 GO:0035767 GO:0034316 GO:2000394 GO:1902463 GO:0031529 GO:0042060
Gene3D	2.130.10.10
InterPro	IPR027340 IPR015505 IPR015048 IPR015049 IPR015943 IPR001680 IPR019775 IPR017986
PANTHER	PTHR10856 PTHR10856:SF16
Pfam	PF08953 PF08954 PF00400
SMART	SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005886	plasma membrane	PMID:15800061^[1]	ECO:0000314			C		Fig. 1A Through immunoflourescence microscopy, the localization of Coronin 1 was found at the plasma membrane.	complete CACAO 6997
	GO:0035767	endothelial cell chemotaxis	PMID:23667561^[2]	ECO:0000315			P		Fig 5	complete CACAO 9416
Contributes to	GO:0035767	endothelial cell chemotaxis	PMID:23667561^[2]	ECO:0000314			P		Rac1 plays a role in S1P-induced redistribution of coronin 1B and cortactin to cell periphery as well as chemotaxis of human pulmonary artery endothelial cells. (Figure 7)	complete CACAO 9417
	GO:0030036	actin cytoskeleton organization	PMID:18775315^[3]	ECO:0000314			P		According to Figure 2C, in the presence of 50 nM Coronin 1B, total actin filament was reduced and branching was less extensive than in the control reactions.	complete CACAO 7800
enables	GO:0045296	cadherin binding	PMID:25468996^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25468996^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	PMID:22619279^[5]	ECO:0000305	curator inference used in manual assertion	GO:0071933	P	occurs_in:(CL:0000359) happens_during:(GO:0072673) happens_during:(GO:0071670)	Seeded From UniProt	complete
enables	GO:0071933	Arp2/3 complex binding	PMID:22619279^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P85970	F		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:22619279^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:22619279^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:22619279^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22619279^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:22619279^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	PMID:22619279^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0071672	negative regulation of smooth muscle cell chemotaxis	PMID:22619279^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:22364218^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:18775315^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	PMID:23667561^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15800061^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000394	positive regulation of lamellipodium morphogenesis	PMID:17350576^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902463	protein localization to cell leading edge	PMID:17350576^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q8WYL5)	Seeded From UniProt	complete
involved_in	GO:0090135	actin filament branching	PMID:18775315^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071933	Arp2/3 complex binding	PMID:18775315^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0071933	Arp2/3 complex binding	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:17456547^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:17456547^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:23667561^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	PMID:23667561^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	PMID:17350576^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	PMID:18775315^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031529	ruffle organization	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:17456547^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:23667561^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:18775315^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23667561^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:16027158^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gatfield, J et al. (2005) Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol. Biol. Cell 16 2786-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Usatyuk, PV et al. (2013) Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. PLoS ONE 8 e63007 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cai, L et al. (2008) Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell 134 828-42 PubMed GONUTS page
↑ ^4.0 ^4.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Williams, HC et al. (2012) Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells. Circ. Res. 111 56-65 PubMed GONUTS page
↑ Chan, KT et al. (2012) Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. Biochem. J. 444 89-96 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Cai, L et al. (2007) Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell 128 915-29 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Cai, L et al. (2005) Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. J. Biol. Chem. 280 31913-23 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cai, L et al. (2007) F-actin binding is essential for coronin 1B function in vivo. J. Cell. Sci. 120 1779-90 PubMed GONUTS page

[PMID:15800061-1] 1.0 ^1.1 Gatfield, J et al. (2005) Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol. Biol. Cell 16 2786-98 PubMed GONUTS page

[PMID:23667561-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Usatyuk, PV et al. (2013) Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. PLoS ONE 8 e63007 PubMed GONUTS page

[PMID:18775315-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Cai, L et al. (2008) Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell 134 828-42 PubMed GONUTS page

[PMID:25468996-4] 4.0 ^4.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:22619279-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Williams, HC et al. (2012) Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells. Circ. Res. 111 56-65 PubMed GONUTS page

[PMID:22364218-6] Chan, KT et al. (2012) Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. Biochem. J. 444 89-96 PubMed GONUTS page

[PMID:21423176-7] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:23533145-8] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:17350576-9] 9.0 ^9.1 ^9.2 Cai, L et al. (2007) Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell 128 915-29 PubMed GONUTS page

[PMID:16027158-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Cai, L et al. (2005) Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. J. Biol. Chem. 280 31913-23 PubMed GONUTS page

[PMID:19199708-11] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:17456547-12] 12.0 ^12.1 ^12.2 Cai, L et al. (2007) F-actin binding is essential for coronin 1B function in vivo. J. Cell. Sci. 120 1779-90 PubMed GONUTS page

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HUMAN:COR1B

Contents

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Notes

References

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