GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
|Status||Page||Date/Time||GO Term (Aspect)||Reference||Evidence||Notes||Links|
|XANC5:Q3BUB5||2013-04-09 12:22:03 CDT||GO:0043709 cell adhesion involved in single-species biofilm formation (P)||PMID:21995764||ECO:0000315 mutant phenotype evidence used in manual assertion|
rpfC and rpfG make up a two component system that is responsible for the perception and transduction a signal molecule . Figure 1 shows that rpfG is involved in the enhancement of Xanthomona citri virulence. Mutations rpfG showed a reduction in the virulence of X. citri as measured by canker lesions on the Duncan Grapefruit leaf.
|MOUSE:HIPK1||2013-04-09 13:04:19 CDT||GO:0034333 adherens junction assembly (P)||PMID:23565059||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 1(I-J') shows that HIPK1 -/- mice showed a reduced size and density of adherens junctions as compared to the control group.
|MOUSE:UBQL1||2013-04-11 20:22:55 CDT||GO:0034140 negative regulation of toll-like receptor 3 signaling pathway (P)||PMID:21695056||ECO:0000315 mutant phenotype evidence used in manual assertion|
(Figure 1C)The lab group performed a series of reporter assays and found that PLIC-1 is a potent inhibitor of the TLR3-Trif pathway. Over expression of mouse PLIC-1 inhibited Trif-dependent activation of the NFk-B dependent Reporter.
|ECOLI:MENI||2013-04-11 21:27:32 CDT||GO:0009234 menaquinone biosynthetic process (P)||PMID:23564174||ECO:0000315 mutant phenotype evidence used in manual assertion|
(Figure 4a) ydiI mutants produced 67% less menaquinone-8 than the parent strain.
|?||2013-04-11 22:11:01 CDT||GO:0010389 regulation of G2/M transition of mitotic cell cycle ((Figure 4.H,I) H3f3b knockouts had a 40% increase in G2/M phase cells compared to the wild type. G0/G1 phase was decreased from 54% to 42%. This was measured with flow cytometry for DNA content.)||PMID:23570311||IMP: Inferred from Mutant Phenotype||challenge|
|MOUSE:SIR4||2013-04-13 17:05:49 CDT||GO:0000820 regulation of glutamine family amino acid metabolic process (P)||PMID:23562301||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 5) SIR4 knock out cells grew significantly faster than wild type cells. Over expression of SIR4 cells were significantly inhibited in their growth as compared to wild type cells.
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