User:Reddenc1

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	XANC5:Q3BUB5	2013-04-09 12:22:03 CDT	GO:0043709 cell adhesion involved in single-species biofilm formation (P)	PMID:21995764	ECO:0000315 mutant phenotype evidence used in manual assertion	rpfC and rpfG make up a two component system that is responsible for the perception and transduction a signal molecule . Figure 1 shows that rpfG is involved in the enhancement of Xanthomona citri virulence. Mutations rpfG showed a reduction in the virulence of X. citri as measured by canker lesions on the Duncan Grapefruit leaf.	challenge
acceptable	MOUSE:HIPK1	2013-04-09 13:04:19 CDT	GO:0034333 adherens junction assembly (P)	PMID:23565059	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1(I-J') shows that HIPK1 -/- mice showed a reduced size and density of adherens junctions as compared to the control group.	challenge
acceptable	MOUSE:UBQL1	2013-04-11 20:22:55 CDT	GO:0034140 negative regulation of toll-like receptor 3 signaling pathway (P)	PMID:21695056	ECO:0000315 mutant phenotype evidence used in manual assertion	(Figure 1C)The lab group performed a series of reporter assays and found that PLIC-1 is a potent inhibitor of the TLR3-Trif pathway. Over expression of mouse PLIC-1 inhibited Trif-dependent activation of the NFk-B dependent Reporter.	challenge
updatedbyinstructor	ECOLI:MENI	2013-04-11 21:27:32 CDT	GO:0009234 menaquinone biosynthetic process (P)	PMID:23564174	ECO:0000315 mutant phenotype evidence used in manual assertion	(Figure 4a) ydiI mutants produced 67% less menaquinone-8 than the parent strain.	challenge
requireschanges	?	2013-04-11 22:11:01 CDT	GO:0010389 regulation of G2/M transition of mitotic cell cycle ((Figure 4.H,I) H3f3b knockouts had a 40% increase in G2/M phase cells compared to the wild type. G0/G1 phase was decreased from 54% to 42%. This was measured with flow cytometry for DNA content.)	PMID:23570311	IMP: Inferred from Mutant Phenotype		challenge
updatedbyinstructor	MOUSE:SIR4	2013-04-13 17:05:49 CDT	GO:0000820 regulation of glutamine family amino acid metabolic process (P)	PMID:23562301	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 5) SIR4 knock out cells grew significantly faster than wild type cells. Over expression of SIR4 cells were significantly inhibited in their growth as compared to wild type cells.	challenge

acceptable:2
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Reddenc1

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Lallison2012, Team Bonfire	MOUSE:GDF8	GO:0033673 - negative regulation of kinase activity (P)	PMID:19357233	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3
requireschanges	Dylan.browning, Team Phatty Acidz	MOUSE:CLN8	GO:0045184 - establishment of protein localization (P)	PMID:23142642	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
updatedbyinstructor	Sbuschbach, Team Worminator	CAEEL:Q18534	GO:0043052 - thermotaxis (P)	PMID:21368276	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Djgulizia, Team Texas Aggies	MOUSE:WNT5A	GO:0071542 - dopaminergic neuron differentiation (P)	PMID:23324743	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Jlieblich, Team Let's Take This Outside	HUMAN:PIM1	GO:0070561 - vitamin D receptor signaling pathway (P)	PMID:22720752	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4 fixed by Reddenc1
updatedbyinstructor	Nazarud1, Team Wheat Thins	SPIOL:O50054	GO:0009631 - cold acclimation (P)	PMID:9536054	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2

1 annotations fixed by Reddenc1

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