User:Lallison2012

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	HUMAN:GDF8	2013-02-04 04:32:55 CST	GO:0045662 negative regulation of myoblast differentiation (P)	PMID:19357233	ECO:0000314 direct assay evidence used in manual assertion	Fig. 1 & 4A	challenge
acceptable	HUMAN:GDF8	2013-02-04 05:05:28 CST	GO:0046716 muscle cell homeostasis (P)	PMID:19357233	ECO:0000314 direct assay evidence used in manual assertion	Results section/ Myostatin reduces diameters...section/last sentence; Fig. 5c; states myostatin inhibits genes required for muscle maintenance [homeostatsis of muscle] instead of alternative atrophy pathway	challenge
updatedbyinstructor	MOUSE:GDF8	2013-02-04 05:50:25 CST	GO:0033673 negative regulation of kinase activity (P)	PMID:19357233	ECO:0000315 mutant phenotype evidence used in manual assertion	Results section/ Increased muscle weight and CK activity... Section; Fig. 7 B; Show Creatine Kinase activity increased by myostatin expression inhitbion in vivo [mice], activity bio marker used. Mice had Severe Combined Immunodeficiency and no MSTN mutations	challenge
acceptable	MOUSE:GDF8	2013-02-04 10:05:06 CST	GO:0046627 negative regulation of insulin receptor signaling pathway (P)	PMID:16182246	ECO:0000315 mutant phenotype evidence used in manual assertion	Responses of insulin action.. Section; Fig 3; muscle protein kinase Akt intermediate phosphorylation was measured due to is role in the insulin signaling pathway, transgenic mice showed greater levels [inhibition of myostatin] of phosphorylation	challenge
acceptable	BOVIN:GDF8	2013-02-10 12:29:37 CST	GO:0048147 negative regulation of fibroblast proliferation (P)	PMID:23268959	ECO:0000314 direct assay evidence used in manual assertion	Figure 1; Indicates a significant inhibition of fibroblast [NIH3T3, mouse] cell proliferation by myostatin [recombinant, bovine] compared to control. Myostatin fibroblast inhibition directly stated in: Results Section/1st paragraph/last sentence.	challenge
acceptable	HUMAN:GDF8	2013-02-10 12:36:27 CST	GO:0051898 negative regulation of protein kinase B signaling cascade (P)	PMID:19357233	ECO:0000314 direct assay evidence used in manual assertion	Fig. 3; Fig 4; demonstrate that mysostatin inhibits the activation of the Akt signaling pathway in differentiating HuSkMC	challenge

acceptable:4
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Lallison2012

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Lallison2012

What do the icons mean in the status column?