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PMID:22720752
| Citation |
Maier, CJ, Maier, RH, Rid, R, Trost, A, Hundsberger, H, Eger, A, Hintner, H, Bauer, JW and Onder, K (2012) PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC Mol. Biol. 13:18 |
|---|---|
| Abstract |
The vitamin D3 receptor (VDR) is responsible for mediating the pleiotropic and, in part, cell-type-specific effects of 1,25-dihydroxyvitamin D3 (calcitriol) on the cardiovascular and the muscle system, on the bone development and maintenance, mineral homeostasis, cell proliferation, cell differentiation, vitamin D metabolism, and immune response modulation. |
| Links |
PubMed PMC3404970 Online version:10.1186/1471-2199-13-18 |
| Keywords |
Calcitriol/metabolism; Cell Line; Cell Nucleus/metabolism; DNA/metabolism; Humans; Protein Binding; Protein Isoforms/chemistry; Protein Isoforms/metabolism; Protein Structure, Tertiary; Proto-Oncogene Proteins c-pim-1/antagonists & inhibitors; Proto-Oncogene Proteins c-pim-1/genetics; Proto-Oncogene Proteins c-pim-1/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Receptors, Calcitriol/chemistry; Receptors, Calcitriol/metabolism; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0070561: vitamin D receptor signaling pathway |
ECO:0000315: |
P |
Fig 5 & 6 |
complete | ||||
|
involved_in |
GO:0070561: vitamin D receptor signaling pathway |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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