HUMAN:PIM1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIM1
Protein Name(s)	Serine/threonine-protein kinase pim-1
External Links
UniProt	P11309
EMBL	M27903 M16750 M54915 M24779 DQ022562 AL353579 CH471081 BC020224 AF386792
CCDS	CCDS4830.1
PIR	JU0327
RefSeq	NP_001230115.1 NP_002639.1
UniGene	Hs.81170
PDB	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MED 4N6Y 4N6Z 4N70
PDBsum	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MED 4N6Y 4N6Z 4N70
DisProt	DP00322
ProteinModelPortal	P11309
SMR	P11309
BioGrid	111310
IntAct	P11309
MINT	MINT-1412755
STRING	9606.ENSP00000362608
BindingDB	P11309
ChEMBL	CHEMBL2147
DrugBank	DB00131
GuidetoPHARMACOLOGY	2158
PhosphoSite	P11309
DMDM	83305339
MaxQB	P11309
PaxDb	P11309
PRIDE	P11309
DNASU	5292
Ensembl	ENST00000373509
GeneID	5292
KEGG	hsa:5292
UCSC	uc003onk.3
CTD	5292
GeneCards	GC06P037137
HGNC	HGNC:8986
HPA	CAB017040 HPA003941
MIM	164960
neXtProt	NX_P11309
PharmGKB	PA33318
eggNOG	COG0515
GeneTree	ENSGT00760000119045
HOGENOM	HOG000231357
HOVERGEN	HBG106681
InParanoid	P11309
KO	K04702
OMA	ERPENVK
OrthoDB	EOG7NW6B0
PhylomeDB	P11309
TreeFam	TF320810
SignaLink	P11309
ChiTaRS	PIM1
EvolutionaryTrace	P11309
GeneWiki	PIM1
GenomeRNAi	5292
NextBio	20450
PRO	PR:P11309
Proteomes	UP000005640
Bgee	P11309
CleanEx	HS_PIM1
ExpressionAtlas	P11309
Genevestigator	P11309
GO	GO:0005737 GO:0005634 GO:0005886 GO:0005524 GO:0030145 GO:0004674 GO:0043024 GO:0008134 GO:0006915 GO:0007049 GO:0008283 GO:0030212 GO:0007275 GO:0043066 GO:0043433 GO:0031659 GO:0046777 GO:0006468
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 IPR017348
Pfam	PF00069
PIRSF	PIRSF037993
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070561	vitamin D receptor signaling pathway	PMID:22720752^[1]	ECO:0000315			P		Fig 5 & 6	complete CACAO 6447
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:21474815^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905062	positive regulation of cardioblast proliferation	PMID:21474815^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070561	vitamin D receptor signaling pathway	PMID:22720752^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:16266891^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16186805^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043024	ribosomal small subunit binding	PMID:16266891^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P39019	F		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:1825810^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:16186805^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18593906^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16266891^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P39019)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:1825810^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:1825810^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:1825810^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:1825810^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21474815^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)\|part_of:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21474815^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001122685 RGD:620462 UniProtKB:P11309	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001122685 UniProtKB:P11309	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97584 MGI:MGI:97587 PANTHER:PTN001122685 RGD:620462 UniProtKB:P11309 UniProtKB:Q86V86 UniProtKB:Q9P1W9	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902033	regulation of hematopoietic stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	P		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06803 ensembl:ENSMUSP00000024811	F		Seeded From UniProt	complete
involved_in	GO:0030212	hyaluronan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26794 ensembl:ENSRNOP00000000637	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017348	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR017348	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017348	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:18593906^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0000082)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18593906^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:2682662^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6790036	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Maier, CJ et al. (2012) PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC Mol. Biol. 13 18 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Katare, R et al. (2011) Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ. Res. 108 1238-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Chiocchetti, A et al. (2005) Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein. Haematologica 90 1453-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Morishita, D et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 68 5076-85 PubMed GONUTS page
↑ ^5.0 ^5.1 Xie, Y et al. (2006) The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene 25 70-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Saris, CJ et al. (1991) The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 10 655-64 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Amson, R et al. (1989) The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. U.S.A. 86 8857-61 PubMed GONUTS page

[PMID:22720752-1] 1.0 ^1.1 Maier, CJ et al. (2012) PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC Mol. Biol. 13 18 PubMed GONUTS page

[PMID:21474815-2] 2.0 ^2.1 ^2.2 ^2.3 Katare, R et al. (2011) Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ. Res. 108 1238-51 PubMed GONUTS page

[PMID:16266891-3] 3.0 ^3.1 ^3.2 Chiocchetti, A et al. (2005) Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein. Haematologica 90 1453-62 PubMed GONUTS page

[PMID:18593906-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Morishita, D et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 68 5076-85 PubMed GONUTS page

[PMID:16186805-5] 5.0 ^5.1 Xie, Y et al. (2006) The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene 25 70-8 PubMed GONUTS page

[PMID:1825810-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Saris, CJ et al. (1991) The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 10 655-64 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2682662-8] Amson, R et al. (1989) The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. U.S.A. 86 8857-61 PubMed GONUTS page

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HUMAN:PIM1

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