PMID:2682662

Citation	Amson, R, Sigaux, F, Przedborski, S, Flandrin, G, Givol, D and Telerman, A (1989) The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. U.S.A. 86:8857-61
Abstract	We measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies. Our data indicate that during human fetal hematopoiesis the 33-kDa pim product, p33pim, is highly expressed in the liver and spleen. In contrast, at the adult stage it is only slightly expressed in circulating granulocytes. Out of 70 hematopoietic malignancies analyzed, 51 patients and 19 cell lines, p33pim was overexpressed in approximately 30% of the samples, particularly in myeloid and lymphoid acute leukemias. This overexpression was unrelated to any stage of cellular differentiation and was not due to gene rearrangement or amplification. These results imply a physiological role of the pim-1 protooncogene during hematopoietic development and a deregulation in various leukemias.
Links	PubMed PMC298389
Keywords	Adult; Antibodies, Monoclonal/diagnostic use; Blotting, Southern; Blotting, Western; Cell Line; Fetus/physiology; Gene Expression; Hematopoiesis; Humans; Leukemia/enzymology; Leukemia/genetics; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases/genetics; Proto-Oncogene Proteins/analysis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-pim-1; Proto-Oncogenes
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Significance

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:PIM1	involved_in	GO:0007275: multicellular organism development	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

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