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MOUSE:UBQL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ubqln1 (synonyms: Plic1)
Protein Name(s) Ubiquilin-1

Protein linking IAP with cytoskeleton 1 PLIC-1

External Links
UniProt Q8R317
EMBL AF177345
AK048534
AK049298
AK004183
BC010213
BC026847
BC027375
BC028857
BC051098
CCDS CCDS26569.1
CCDS49281.1
RefSeq NP_081118.4
NP_689420.1
UniGene Mm.182053
ProteinModelPortal Q8R317
SMR Q8R317
BioGrid 207807
IntAct Q8R317
MINT MINT-4139320
PhosphoSite Q8R317
REPRODUCTION-2DPAGE Q8R317
MaxQB Q8R317
PaxDb Q8R317
PRIDE Q8R317
Ensembl ENSMUST00000058735
ENSMUST00000076454
GeneID 56085
KEGG mmu:56085
UCSC uc007qtl.2
uc007qtm.2
CTD 29979
MGI MGI:1860276
eggNOG COG5272
GeneTree ENSGT00390000005720
HOVERGEN HBG064537
InParanoid Q8R317
KO K04523
OMA YRIASSH
OrthoDB EOG7HF1J8
PhylomeDB Q8R317
TreeFam TF314412
ChiTaRS Ubqln1
NextBio 311884
PRO PR:Q8R317
Proteomes UP000000589
Bgee Q8R317
CleanEx MM_UBQLN1
ExpressionAtlas Q8R317
Genevestigator Q8R317
GO GO:0005737
GO:0005783
GO:0005634
GO:0048471
GO:0000502
GO:0019215
GO:0019900
GO:0005102
GO:0071456
GO:1902175
GO:0031396
GO:0034976
InterPro IPR006636
IPR009060
IPR015940
IPR000449
IPR015496
IPR000626
IPR029071
IPR028799
PANTHER PTHR10677
PTHR10677:SF16
Pfam PF00627
PF00240
SMART SM00727
SM00165
SM00213
SUPFAM SSF46934
SSF54236
PROSITE PS50030
PS50053

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0034140

negative regulation of toll-like receptor 3 signaling pathway

PMID:21695056[1]

ECO:0000315

P

(Figure 1C)The lab group performed a series of reporter assays and found that PLIC-1 is a potent inhibitor of the TLR3-Trif pathway. Over expression of mouse PLIC-1 inhibited Trif-dependent activation of the NFk-B dependent Reporter.

complete
CACAO 7685

involved_in

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0016235

aggresome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

involved_in

GO:0035973

aggrephagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

PMID:20529957[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030433

ubiquitin-dependent ERAD pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

involved_in

GO:1901340

negative regulation of store-operated calcium channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

involved_in

GO:0031398

positive regulation of protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

involved_in

GO:0034140

negative regulation of toll-like receptor 3 signaling pathway

PMID:21695056[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902175

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

involved_in

GO:0031396

regulation of protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

enables

GO:0019215

intermediate filament binding

PMID:10549293[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:10549293[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000073411
PomBase:SPAC26A3.16
TAIR:locus:2059677
TAIR:locus:2059682
UniProtKB:Q9NRR5
UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

involved_in

GO:0030433

ubiquitin-dependent ERAD pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000073487
UniProtKB:Q9UHD9
UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000073487
UniProtKB:Q9UHD9

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031057
PANTHER:PTN000073411
SGD:S000004889
UniProtKB:Q9UHD9
UniProtKB:Q9UMX0
WB:WBGene00008852

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2150152
PANTHER:PTN000073411
TAIR:locus:2059677
TAIR:locus:2059682
UniProtKB:Q9UHD9
UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860276
PANTHER:PTN000073502
UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000073487
UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902175

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901340

negative regulation of store-operated calcium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097352

autophagosome maturation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035973

aggrephagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031398

positive regulation of protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031396

regulation of protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030433

ubiquitin-dependent ERAD pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620745

F

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016236

macroautophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

part_of

GO:0016235

aggresome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620745

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000045

autophagosome assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UMX0

P

Seeded From UniProt

complete

involved_in

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:1902175

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:1901340

negative regulation of store-operated calcium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:0097352

autophagosome maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

F

Seeded From UniProt

complete

involved_in

GO:0035973

aggrephagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

enables

GO:0031593

polyubiquitin modification-dependent protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

F

Seeded From UniProt

complete

involved_in

GO:0031398

positive regulation of protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:0031396

regulation of protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

involved_in

GO:0030433

ubiquitin-dependent ERAD pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

F

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

part_of

GO:0016235

aggresome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UMX0
ensembl:ENSP00000365576

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

part_of

GO:0000502

proteasome complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0647

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Biswas, N et al. (2011) The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling. PLoS ONE 6 e21153 PubMed GONUTS page
  2. Rothenberg, C et al. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum. Mol. Genet. 19 3219-32 PubMed GONUTS page
  3. 3.0 3.1 Wu, AL et al. (1999) Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol. Cell 4 619-25 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page