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MOUSE:UBQL1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Ubqln1 (synonyms: Plic1) | |
Protein Name(s) | Ubiquilin-1
Protein linking IAP with cytoskeleton 1 PLIC-1 | |
External Links | ||
UniProt | Q8R317 | |
EMBL | AF177345 AK048534 AK049298 AK004183 BC010213 BC026847 BC027375 BC028857 BC051098 | |
CCDS | CCDS26569.1 CCDS49281.1 | |
RefSeq | NP_081118.4 NP_689420.1 | |
UniGene | Mm.182053 | |
ProteinModelPortal | Q8R317 | |
SMR | Q8R317 | |
BioGrid | 207807 | |
IntAct | Q8R317 | |
MINT | MINT-4139320 | |
PhosphoSite | Q8R317 | |
REPRODUCTION-2DPAGE | Q8R317 | |
MaxQB | Q8R317 | |
PaxDb | Q8R317 | |
PRIDE | Q8R317 | |
Ensembl | ENSMUST00000058735 ENSMUST00000076454 | |
GeneID | 56085 | |
KEGG | mmu:56085 | |
UCSC | uc007qtl.2 uc007qtm.2 | |
CTD | 29979 | |
MGI | MGI:1860276 | |
eggNOG | COG5272 | |
GeneTree | ENSGT00390000005720 | |
HOVERGEN | HBG064537 | |
InParanoid | Q8R317 | |
KO | K04523 | |
OMA | YRIASSH | |
OrthoDB | EOG7HF1J8 | |
PhylomeDB | Q8R317 | |
TreeFam | TF314412 | |
ChiTaRS | Ubqln1 | |
NextBio | 311884 | |
PRO | PR:Q8R317 | |
Proteomes | UP000000589 | |
Bgee | Q8R317 | |
CleanEx | MM_UBQLN1 | |
ExpressionAtlas | Q8R317 | |
Genevestigator | Q8R317 | |
GO | GO:0005737 GO:0005783 GO:0005634 GO:0048471 GO:0000502 GO:0019215 GO:0019900 GO:0005102 GO:0071456 GO:1902175 GO:0031396 GO:0034976 | |
InterPro | IPR006636 IPR009060 IPR015940 IPR000449 IPR015496 IPR000626 IPR029071 IPR028799 | |
PANTHER | PTHR10677 PTHR10677:SF16 | |
Pfam | PF00627 PF00240 | |
SMART | SM00727 SM00165 SM00213 | |
SUPFAM | SSF46934 SSF54236 | |
PROSITE | PS50030 PS50053 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000315 |
P |
(Figure 1C)The lab group performed a series of reporter assays and found that PLIC-1 is a potent inhibitor of the TLR3-Trif pathway. Over expression of mouse PLIC-1 inhibited Trif-dependent activation of the NFk-B dependent Reporter. |
complete | |||||
involved_in |
GO:1903071 |
positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016235 |
aggresome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035973 |
aggrephagy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005776 |
autophagosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031593 |
polyubiquitin modification-dependent protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901340 |
negative regulation of store-operated calcium channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902175 |
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019900 |
kinase binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019215 |
intermediate filament binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0031593 |
polyubiquitin modification-dependent protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000073411 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000073487 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016241 |
regulation of macroautophagy |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000073487 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0031057 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2150152 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005776 |
autophagosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1860276 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000073487 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1903071 |
positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902175 |
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901340 |
negative regulation of store-operated calcium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097352 |
autophagosome maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071456 |
cellular response to hypoxia |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035973 |
aggrephagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0031593 |
polyubiquitin modification-dependent protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620745 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019900 |
kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0016236 |
macroautophagy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016235 |
aggresome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005776 |
autophagosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620745 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000045 |
autophagosome assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903071 |
positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902175 |
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901340 |
negative regulation of store-operated calcium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097352 |
autophagosome maturation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035973 |
aggrephagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0031593 |
polyubiquitin modification-dependent protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031396 |
regulation of protein ubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030433 |
ubiquitin-dependent ERAD pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019900 |
kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016236 |
macroautophagy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016235 |
aggresome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005776 |
autophagosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UMX0 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000502 |
proteasome complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005776 |
autophagosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Biswas, N et al. (2011) The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling. PLoS ONE 6 e21153 PubMed GONUTS page
- ↑ Rothenberg, C et al. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum. Mol. Genet. 19 3219-32 PubMed GONUTS page
- ↑ 3.0 3.1 Wu, AL et al. (1999) Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol. Cell 4 619-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0048471 ! perinuclear region of cytoplasm
- GO:0005886 ! plasma membrane
- GO:0031593 ! polyubiquitin modification-dependent protein binding
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:0000502 ! proteasome complex
- GO:0032991 ! protein-containing complex
- GO:0019904 ! protein domain specific binding
r