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PMID:21695056
| Citation |
Biswas, N, Liu, S, Ronni, T, Aussenberg, SE, Liu, W, Fujita, T and Wang, T (2011) The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling. PLoS ONE 6:e21153 |
|---|---|
| Abstract |
The innate immune responses to virus infection are initiated by either Toll-like receptors (TLR3/7/8/9) or cytoplasmic double-stranded RNA (dsRNA)-recognizing RNA helicases RIG-I and MDA5. To avoid causing injury to the host, these signaling pathways must be switched off in time by negative regulators. |
| Links |
PubMed PMC3117881 Online version:10.1371/journal.pone.0021153 |
| Keywords |
Adaptor Proteins, Signal Transducing/metabolism; Adaptor Proteins, Vesicular Transport/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Down-Regulation/drug effects; Gene Knockdown Techniques; Genes, Reporter/genetics; HEK293 Cells; Humans; Interferon-beta/genetics; Luciferases/genetics; NF-kappa B/metabolism; Newcastle disease virus/drug effects; Newcastle disease virus/physiology; Poly I-C/pharmacology; Promoter Regions, Genetic/genetics; Protein Transport/drug effects; RNA, Small Interfering/genetics; Signal Transduction/drug effects; Signal Transduction/genetics; Toll-Like Receptor 3/metabolism; Two-Hybrid System Techniques |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0034140: negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000315: |
P |
(Figure 1C)The lab group performed a series of reporter assays and found that PLIC-1 is a potent inhibitor of the TLR3-Trif pathway. Over expression of mouse PLIC-1 inhibited Trif-dependent activation of the NFk-B dependent Reporter. |
complete | ||||
|
involved_in |
GO:0034140: negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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