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Guo, Y, Zhang, Y, Li, JL and Wang, N (2012) Diffusible signal factor-mediated quorum sensing plays a central role in coordinating gene expression of Xanthomonas citri subsp. citri. Mol. Plant Microbe Interact. 25:165-79


Diffusible signal factor (DSF) family signal-mediated quorum sensing (QS) has been identified in many gram-negative bacteria. This QS pathway of Xanthomonas spp. consists of three major QS components: RpfF, RpfC, and RpfG. The rpfF gene encodes a putative enoyl-CoA hydratase that catalyzes the synthesis of the signal molecule. RpfC and RpfG serve as a two-component system for the perception and transduction of the extracellular DSF family signals. In order to further characterize the QS regulatory network in Xanthomonas citri subsp. citri, we investigated the RpfF, RpfC, and RpfG regulons by using transcriptome analyses. Comparison of the transcriptomes of the QS mutants (rpfF, rpfC, and rpfG) with that of the wild-type strain revealed a core group of genes controlled by all three QS components, suggesting that the RpfC-RpfG two-component system is a major and conserved signal perception and transduction system for DSF family signal-mediated QS in X. citri subsp. citri. The unique genes controlled by RpfF alone indicate the complexity of the QS pathway and the involvement of additional sensory mechanisms in X. citri subsp. citri. The unique genes controlled by RpfC and RpfG, respectively, support the possibility that RpfC and RpfG play broader roles in gene regulation other than transduction of DSF signals.


PubMed Online version:10.1094/MPMI-07-11-0184




Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0043709: cell adhesion involved in single-species biofilm formation

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt



GO:0043709: cell adhesion involved in single-species biofilm formation



rpfC and rpfG make up a two component system that is responsible for the perception and transduction a signal molecule . Figure 1 shows that rpfG is involved in the enhancement of Xanthomona citri virulence. Mutations rpfG showed a reduction in the virulence of X. citri as measured by canker lesions on the Duncan Grapefruit leaf.

CACAO 7433

See also


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