CAEEL:Q18534

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein NPR-1 (ECO:0000313 with EMBL:CCD67081.1)
External Links
UniProt	Q18534
EMBL	FO080826
PIR	T29741
RefSeq	NP_508816.1
UniGene	Cel.621
ProteinModelPortal	Q18534
SMR	Q18534
STRING	6239.C39E6.6
PaxDb	Q18534
PRIDE	Q18534
EnsemblMetazoa	C39E6.6
GeneID	180752
KEGG	cel:CELE_C39E6.6
UCSC	C39E6.6
CTD	180752
WormBase	C39E6.6
eggNOG	NOG149782
GeneTree	ENSGT00760000118781
HOGENOM	HOG000020311
InParanoid	Q18534
OMA	LESSCAF
OrthoDB	EOG7RFTHZ
PhylomeDB	Q18534
NextBio	910772
PRO	PR:Q18534
Proteomes	UP000001940
GO	GO:0030424 GO:0030425 GO:0005887 GO:0043025 GO:0008188 GO:0004983 GO:0007631 GO:0007218 GO:0045471 GO:0070482
InterPro	IPR000276 IPR017452 IPR000611
Pfam	PF00001
PRINTS	PR00237 PR01012
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0043052	thermotaxis	PMID:21368276^[1]	ECO:0000315			P	Fig 6 or 7	complete CACAO 7305
part_of	GO:0005886	plasma membrane	PMID:12821653^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P48182,UniProtKB:Q9N4V0	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P48182,UniProtKB:Q6F3C9,UniProtKB:Q9N4V0	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P48182,UniProtKB:Q6F3C9	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P48182	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41855,UniProtKB:P48182,UniProtKB:Q6F3C9	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	PMID:23658528^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41855,UniProtKB:P48182	P	Seeded From UniProt	complete
involved_in	GO:1904068	G protein-coupled receptor signaling pathway involved in social behavior	PMID:14555955^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:21368276^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070482	response to oxygen levels	PMID:15220933^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00000046 WB:WBVar00145397	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:15182714^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00000046 WB:WBVar00088388 WB:WBVar00090144	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12410311^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:12410311^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:12410311^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008188	neuropeptide receptor activity	PMID:14555955^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008188	neuropeptide receptor activity	PMID:12821653^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:15220933^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00000046 WB:WBVar00145397	P	Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	PMID:14555955^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:14555955^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:12821653^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:14555955^[4]	ECO:0000305	curator inference used in manual assertion	GO:0008188	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004983	neuropeptide Y receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000611	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000611	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000611 InterPro:IPR017452	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Glauser, DA et al. (2011) Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics 188 91-103 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kubiak, TM et al. (2003) Differential activation of "social" and "solitary" variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9. J. Biol. Chem. 278 33724-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Stawicki, TM et al. (2013) Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 9 e1003472 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Rogers, C et al. (2003) Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nat. Neurosci. 6 1178-85 PubMed GONUTS page
↑ ^5.0 ^5.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page
↑ Davies, AG et al. (2004) Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. Neuron 42 731-43 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Coates, JC & de Bono, M (2002) Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature 419 925-9 PubMed GONUTS page

[PMID:21368276-1] 1.0 ^1.1 Glauser, DA et al. (2011) Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics 188 91-103 PubMed GONUTS page

[PMID:12821653-2] 2.0 ^2.1 ^2.2 Kubiak, TM et al. (2003) Differential activation of "social" and "solitary" variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9. J. Biol. Chem. 278 33724-9 PubMed GONUTS page

[PMID:23658528-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Stawicki, TM et al. (2013) Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 9 e1003472 PubMed GONUTS page

[PMID:14555955-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Rogers, C et al. (2003) Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nat. Neurosci. 6 1178-85 PubMed GONUTS page

[PMID:15220933-5] 5.0 ^5.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page

[PMID:15182714-6] Davies, AG et al. (2004) Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. Neuron 42 731-43 PubMed GONUTS page

[PMID:12410311-7] 7.0 ^7.1 ^7.2 Coates, JC & de Bono, M (2002) Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature 419 925-9 PubMed GONUTS page

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CAEEL:Q18534

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