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PMID:15220933
| Citation |
Gray, JM, Karow, DS, Lu, H, Chang, AJ, Chang, JS, Ellis, RE, Marletta, MA and Bargmann, CI (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430:317-22 |
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| Abstract |
Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen, avoiding higher and lower oxygen levels. 3',5'-cyclic guanosine monophosphate (cGMP) is a common second messenger in sensory transduction and is implicated in oxygen sensation. Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35. The GCY-35 haem domain binds molecular oxygen, unlike the haem domains of classical nitric-oxide-regulated guanylate cyclases. GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans. Social feeding and related behaviours occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments. |
| Links |
PubMed Online version:10.1038/nature02714 |
| Keywords |
Animals; Bacteria/genetics; Bacteria/metabolism; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Aggregation/drug effects; Cyclic GMP/metabolism; Feeding Behavior/drug effects; Feeding Behavior/physiology; Food; Gases/metabolism; Guanylate Cyclase/chemistry; Guanylate Cyclase/genetics; Guanylate Cyclase/metabolism; Heme/metabolism; Hyperoxia/enzymology; Hyperoxia/genetics; Hyperoxia/metabolism; Ion Channels/metabolism; Mutation/genetics; Neurons, Afferent/metabolism; Nitric Oxide/metabolism; Nitric Oxide/pharmacology; Oxygen/metabolism; Oxygen/pharmacology; Protein Binding; Protein Structure, Tertiary; Social Behavior |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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