User:Lperilloux

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	MOUSE:UCHL1	2015-02-10 10:53:28 CST	GO:0042985 negative regulation of amyloid precursor protein biosynthetic process (P)	PMID:25466238	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows UCHL 1 reduces the level of mature APP protein	challenge
requireschanges	MOUSE:UCHL1	2015-02-10 10:53:28 CST	GO:0042984 regulation of amyloid precursor protein biosynthetic process (P)	PMID:25466238	ECO:0000314 direct assay evidence used in manual assertion	Figure 1 shows UCHL 1 regulates APP processing	challenge
requireschanges	HUMAN:MTOR	2015-02-10 11:00:14 CST	GO:1902949 positive regulation of tau-protein kinase activity (P)	PMID:23585566	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows mTor directly phosphorylates tau protein	challenge
unacceptable	HUMAN:MTOR	2015-02-10 11:00:15 CST	GO:1903032 negative regulation of microtubule plus-end binding (P)	PMID:23585566	ECO:0000314 direct assay evidence used in manual assertion	Figure 7 shows mTor affects microtubule binding ability	challenge
requireschanges	HUMAN:MTOR	2015-02-10 11:00:15 CST	GO:0034109 homotypic cell-cell adhesion (P)	PMID:23585566	ECO:0000314 direct assay evidence used in manual assertion	Figure 6 shows mTor affects tau aggregation	challenge
requireschanges	DROME:Q7KTX7	2015-02-10 11:14:19 CST	GO:0044743 intracellular protein transmembrane import (P)	PMID:20194754	ECO:0000316 genetic interaction evidence used in manual assertion	Figure 2 shows PINK1 is required for Parkin translocation	challenge
correctedthroughchallenges	DROME:Q7KTX7	2015-02-10 11:14:19 CST	GO:0031398 positive regulation of protein ubiquitination (P)	PMID:20194754	ECO:0000314 direct assay evidence used in manual assertion	Figure 4 shows parkin overexpression can cause mfn ubiquitination in the absense of PINK1	challenge
unacceptable	DROME:Q7KTX7	2015-02-10 11:14:19 CST	GO:0090141 positive regulation of mitochondrial fission (P)	PMID:20194754	ECO:0000316 genetic interaction evidence used in manual assertion	Figure 1 shows Parkin and PINK1 activity promotes mitochondrial fission	challenge
unacceptable	DROME:Q7KTX7	2015-02-10 11:14:20 CST	GO:0010637 negative regulation of mitochondrial fusion (P)	PMID:20194754	ECO:0000316 genetic interaction evidence used in manual assertion	Figure 1 shows Parkin and PINK1 activity inhibits mitochondrial fusion	challenge

acceptable:0
unacceptable:3
requires_changes:5
flagged:0

Annotations challenged by Lperilloux

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Asingh, Team Designated Drinkers	LACCA:K0N2B5	GO:0051117 - ATPase binding (F)	PMID:25658360	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
correctedthroughchallenges	Jderrickson, Team Bio Bois	YEAST:ESS1	GO:0030052 - obsolete parvulin (F)	PMID:24468661	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3 fixed by Min.lorna
requireschanges	Jderrickson, Team Bio Bois	ECO27:ATPE	GO:0045269 - obsolete proton-transporting ATP synthase, central stalk (C)	PMID:25603139	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
unacceptable	Jderrickson, Team Bio Bois	BOVIN:Q547S4	GO:0032023 - trypsinogen activation (P)	PMID:25637872	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
unacceptable	Jderrickson, Team Bio Bois	HUMAN:RENI	GO:0004195 - obsolete renin activity (F)	PMID:25635129	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
unacceptable	Jderrickson, Team Bio Bois	HUMAN:PEPA3	GO:0004194 - obsolete pepsin A activity (F)	PMID:25633964	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
unacceptable	Jderrickson, Team Bio Bois	HUMAN:CO3	GO:0018103 - protein C-linked glycosylation (P)	PMID:25651845	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
requireschanges	Jderrickson, Team Bio Bois	HUMAN:ELNE	GO:0035579 - specific granule membrane (C)	PMID:25652853	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
correctedthroughchallenges	Jderrickson, Team Bio Bois	HUMAN:MASP1	GO:0008236 - serine-type peptidase activity (F)	PMID:25617734	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 6 fixed by Brcalk
correctedthroughchallenges	Bbourgoyne, Team Bio Bois	HUMAN:PERT	GO:0004447 - iodide peroxidase activity (F)	PMID:25595679	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4 fixed by Min.lorna
unacceptable	Bbourgoyne, Team Bio Bois	MOUSE:CAPON	GO:0004517 - nitric-oxide synthase activity (F)	PMID:25621792	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
unacceptable	Bbourgoyne, Team Bio Bois	HUMAN:TYRO	GO:0050371 - tyrosine phenol-lyase activity (F)	PMID:25654191	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
requireschanges	Lhicks, Team Ubiquitous Mafia	HUMAN:TOPK	GO:0043433 - negative regulation of DNA-binding transcription factor activity (P)	PMID:25575812	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4
unacceptable	Sedmondson, Team Designated Drinkers	PIG:STF1	GO:0003677 - DNA binding (F)	PMID:25604140	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
correctedthroughchallenges	Ksenagbe, Team Mic Drop	HUMAN:ABCE1	GO:0008428 - ribonuclease inhibitor activity (F)	PMID:25659154	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3 fixed by Brcalk
unacceptable	Mrogers, Team Dos Juanitas	HUMAN:MFGM	GO:0031012 - extracellular matrix (C)	PMID:25659147	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Lperilloux

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