HUMAN:ELNE

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ELANE (synonyms: ELA2)
Protein Name(s)	Neutrophil elastase Bone marrow serine protease Elastase-2 Human leukocyte elastase HLE Medullasin PMN elastase
External Links
UniProt	P08246
EMBL	Y00477 M20203 M20199 M20200 M20201 M34379 AY596461 BC074816 BC074817 D00187 X05875 X05875 J03545 M27783
CCDS	CCDS12045.1
PIR	A31976
RefSeq	NP_001963.1 XP_005259574.1 XP_006725460.1
UniGene	Hs.99863
PDB	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL
PDBsum	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL
ProteinModelPortal	P08246
SMR	P08246
BioGrid	108306
IntAct	P08246
MINT	MINT-1505052
STRING	9606.ENSP00000263621
BindingDB	P08246
ChEMBL	CHEMBL248
DrugBank	DB00058 DB00099 DB00019
GuidetoPHARMACOLOGY	2358
MEROPS	S01.131
DMDM	119292
PaxDb	P08246
PeptideAtlas	P08246
PRIDE	P08246
Ensembl	ENST00000263621 ENST00000590230 ENST00000615489
GeneID	1991
KEGG	hsa:1991
UCSC	uc002lqb.3
CTD	1991
GeneCards	GC19P000854
GeneReviews	ELANE
HGNC	HGNC:3309
HPA	CAB015409
MIM	130130 162800 202700
neXtProt	NX_P08246
Orphanet	486 2686
PharmGKB	PA27735
eggNOG	COG5640
GeneTree	ENSGT00760000118895
HOGENOM	HOG000251820
HOVERGEN	HBG013304
InParanoid	P08246
KO	K01327
OMA	AQFANWI
OrthoDB	EOG7MKW6Q
PhylomeDB	P08246
BRENDA	3.4.21.37
Reactome	REACT_118572 REACT_118682 REACT_150401
SABIO-RK	P08246
EvolutionaryTrace	P08246
GeneWiki	Neutrophil_elastase
GenomeRNAi	1991
NextBio	8051
PRO	PR:P08246
Proteomes	UP000005640 UP000005640
Bgee	P08246
CleanEx	HS_ELA2
ExpressionAtlas	P08246
Genevestigator	P08246
GO	GO:0009986 GO:0005737 GO:0005576 GO:0070062 GO:0030141 GO:0017053 GO:0019955 GO:0004175 GO:0008201 GO:0008233 GO:0002020 GO:0001106 GO:0004252 GO:0002438 GO:0006874 GO:0030574 GO:0042742 GO:0022617 GO:0030198 GO:0050900 GO:0045079 GO:0050922 GO:0044130 GO:0050728 GO:0045415 GO:0000122 GO:0070947 GO:0006909 GO:0050778 GO:0045416 GO:0043406 GO:0048661 GO:0030163 GO:0006508 GO:0032496 GO:0009411 GO:0001878
InterPro	IPR001254 IPR018114 IPR001314 IPR009003
Pfam	PF00089
PRINTS	PR00722
SMART	SM00020
SUPFAM	SSF50494
PROSITE	PS50240 PS00134 PS00135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035579	specific granule membrane	PMID:25652853^[1]	ECO:0000314			C		Over-expression of neutrophil elastase promotes and inhibits apoptosis in K562 cells	complete CACAO 10579
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28344315^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002371)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070945	neutrophil mediated killing of gram-negative bacterium	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070945	neutrophil mediated killing of gram-negative bacterium	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria	PMID:20421939^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:25645918^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0007311)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:19506020^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19506020^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:19506020^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19506020^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:6980881^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:6980881^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08697	F		Seeded From UniProt	complete
involved_in	GO:0050922	negative regulation of chemotaxis	PMID:15140022^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:15140022^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:15010259^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	PMID:14730209^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045415	negative regulation of interleukin-8 biosynthetic process	PMID:12223522^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045079	negative regulation of chemokine biosynthetic process	PMID:12223522^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:14730209^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:14705961^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	PMID:12887060^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:12393522^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09919	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12114510^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:11928814^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:15140022^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:12114510^[17]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:12887060^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2679229 PANTHER:PTN000666593	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95316 PANTHER:PTN001207468 UniProtKB:P08246 UniProtKB:P24158	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001207468 UniProtKB:P08246	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2679229 PANTHER:PTN001207468 UniProtKB:P24158	F		Seeded From UniProt	complete
involved_in	GO:0002438	acute inflammatory response to antigenic stimulus	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2679229 PANTHER:PTN001546391	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903238	positive regulation of leukocyte tethering or rolling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A488 ensembl:ENSRNOP00000014981	P		Seeded From UniProt	complete
involved_in	GO:0002523	leukocyte migration involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A488 ensembl:ENSRNOP00000014981	P		Seeded From UniProt	complete
involved_in	GO:0070947	neutrophil mediated killing of fungus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0050778	positive regulation of immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	F		Seeded From UniProt	complete
involved_in	GO:0002438	acute inflammatory response to antigenic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3UP87 ensembl:ENSMUSP00000038925	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0022617	extracellular matrix disassembly	Reactome:R-HSA-1474228	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-2533972 Reactome:R-NUL-2514835 Reactome:R-NUL-2482182 Reactome:R-HSA-6813659 Reactome:R-HSA-6798751 Reactome:R-HSA-6798749 Reactome:R-HSA-1592398 Reactome:R-HSA-1592316 Reactome:R-HSA-1566962	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	Reactome:R-NUL-2514835 Reactome:R-NUL-2482182	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jiang, K et al. (2015) [Over-expression of neutrophil elastase promotes proliferation and inhibits apoptosis in K562 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 159-62, 167 PubMed GONUTS page
↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Papareddy, P et al. (2010) Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog. 6 e1000857 PubMed GONUTS page
↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Salipante, SJ et al. (2009) Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase. Mol. Cell. Biol. 29 4394-405 PubMed GONUTS page
↑ ^9.0 ^9.1 Brower, MS & Harpel, PC (1982) Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase. J. Biol. Chem. 257 9849-54 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tralau, T et al. (2004) Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. Exp. Dermatol. 13 316-25 PubMed GONUTS page
↑ Huang, CD et al. (2004) Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. Life Sci. 74 2479-92 PubMed GONUTS page
↑ ^12.0 ^12.1 Chen, HC et al. () Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. J. Biomed. Sci. 11 49-58 PubMed GONUTS page
↑ ^13.0 ^13.1 Nemoto, E et al. (2002) Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. J. Leukoc. Biol. 72 538-45 PubMed GONUTS page
↑ Eggers, CT et al. (2004) The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem. J. 379 107-18 PubMed GONUTS page
↑ ^15.0 ^15.1 Dulinski, R et al. (2003) Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins. Biol. Chem. 384 929-37 PubMed GONUTS page
↑ El Ouriaghli, F et al. (2003) Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. Blood 101 1752-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Korkmaz, B et al. (2002) Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. J. Biol. Chem. 277 39074-81 PubMed GONUTS page
↑ Cavarra, E et al. (2002) UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. Biol. Chem. 383 199-206 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page

[PMID:25652853-1] Jiang, K et al. (2015) [Over-expression of neutrophil elastase promotes proliferation and inhibits apoptosis in K562 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31 159-62, 167 PubMed GONUTS page

[PMID:28344315-2] Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page

[PMID:25037231-3] Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:20421939-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Papareddy, P et al. (2010) Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog. 6 e1000857 PubMed GONUTS page

[PMID:25645918-5] Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page

[PMID:23533145-6] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:19506020-8] 8.0 ^8.1 ^8.2 ^8.3 Salipante, SJ et al. (2009) Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase. Mol. Cell. Biol. 29 4394-405 PubMed GONUTS page

[PMID:6980881-9] 9.0 ^9.1 Brower, MS & Harpel, PC (1982) Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase. J. Biol. Chem. 257 9849-54 PubMed GONUTS page

[PMID:15140022-10] 10.0 ^10.1 ^10.2 Tralau, T et al. (2004) Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. Exp. Dermatol. 13 316-25 PubMed GONUTS page

[PMID:15010259-11] Huang, CD et al. (2004) Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. Life Sci. 74 2479-92 PubMed GONUTS page

[PMID:14730209-12] 12.0 ^12.1 Chen, HC et al. () Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway. J. Biomed. Sci. 11 49-58 PubMed GONUTS page

[PMID:12223522-13] 13.0 ^13.1 Nemoto, E et al. (2002) Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production. J. Leukoc. Biol. 72 538-45 PubMed GONUTS page

[PMID:14705961-14] Eggers, CT et al. (2004) The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem. J. 379 107-18 PubMed GONUTS page

[PMID:12887060-15] 15.0 ^15.1 Dulinski, R et al. (2003) Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins. Biol. Chem. 384 929-37 PubMed GONUTS page

[PMID:12393522-16] El Ouriaghli, F et al. (2003) Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. Blood 101 1752-8 PubMed GONUTS page

[PMID:12114510-17] 17.0 ^17.1 Korkmaz, B et al. (2002) Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. J. Biol. Chem. 277 39074-81 PubMed GONUTS page

[PMID:11928814-18] Cavarra, E et al. (2002) UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. Biol. Chem. 383 199-206 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11907569-20] 20.0 ^20.1 ^20.2 ^20.3 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page

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HUMAN:ELNE

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References

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