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HUMAN:TYRO

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TYR
Protein Name(s) Tyrosinase

LB24-AB Monophenol monooxygenase SK29-AB Tumor rejection antigen AB

External Links
UniProt P14679
EMBL M27160
M63239
M63235
M63236
M63237
M63238
J03581
Y00819
U01873
M74314
X16073
AF237811
AF237807
AF237808
AF237809
AF237810
BC027179
AY012019
CCDS CCDS8284.1
PIR A38444
RefSeq NP_000363.1
UniGene Hs.503555
ProteinModelPortal P14679
SMR P14679
BioGrid 113150
STRING 9606.ENSP00000263321
BindingDB P14679
ChEMBL CHEMBL1973
DrugBank DB00548
DB01055
DB00600
GuidetoPHARMACOLOGY 2643
PhosphoSite P14679
DMDM 401235
PaxDb P14679
PRIDE P14679
Ensembl ENST00000263321
GeneID 7299
KEGG hsa:7299
UCSC uc001pcs.3
CTD 7299
GeneCards GC11P088911
GeneReviews TYR
HGNC HGNC:12442
HPA CAB000079
MIM 103470
203100
601800
606933
606952
neXtProt NX_P14679
Orphanet 352734
352740
79431
79434
352737
PharmGKB PA37095
eggNOG NOG08919
GeneTree ENSGT00500000044790
HOVERGEN HBG003553
InParanoid P14679
KO K00505
OMA CLSLTQY
OrthoDB EOG7TJ3HG
PhylomeDB P14679
TreeFam TF315865
BioCyc MetaCyc:HS01248-MONOMER
SABIO-RK P14679
GeneWiki Tyrosinase
GenomeRNAi 7299
NextBio 28547
PRO PR:P14679
Proteomes UP000005640
Bgee P14679
CleanEx HS_TYR
ExpressionAtlas P14679
Genevestigator P14679
GO GO:0005737
GO:0005798
GO:0016021
GO:0005764
GO:0042470
GO:0033162
GO:0048471
GO:0005507
GO:0004503
GO:0046982
GO:0042803
GO:0008283
GO:0006726
GO:0006583
GO:0048538
GO:0007601
Gene3D 1.10.1280.10
InterPro IPR002227
IPR008922
Pfam PF00264
PRINTS PR00092
SUPFAM SSF48056
PROSITE PS00497
PS00498

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042438

melanin biosynthetic process

PMID:8126111[1]

ECO:0000314

P

Based on the results in fig 5.

complete
CACAO 2234

Colocalizes with

GO:0042470

melanosome

PMID:1145200[2]

ECO:0000314

C

Fig. 5: normal melanosomes stain for Tyrosinase.

complete
CACAO 2451

Contributes to

GO:0050371

tyrosine phenol-lyase activity

PMID:25654191[3]

ECO:0000314

F

Degrades tyrosine and generates free radicals in the process

complete
CACAO 10569

colocalizes_with

GO:0042470

melanosome

PMID:1145200[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042438

melanin biosynthetic process

PMID:8126111[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:11092760[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11344

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11344

F

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P11344

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11092760[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

PMID:11092760[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004503

monophenol monooxygenase activity

PMID:11092760[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043473

pigmentation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98880
PANTHER:PTN001352375
RGD:1589755
ZFIN:ZDB-GENE-991026-3

P

Seeded From UniProt

complete

colocalizes_with

GO:0042470

melanosome

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98880
PANTHER:PTN001352375
UniProtKB:P14679

C

Seeded From UniProt

complete

involved_in

GO:0042438

melanin biosynthetic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98880
PANTHER:PTN001352375
UniProtKB:P14679

P

Seeded From UniProt

complete

enables

GO:0004503

monophenol monooxygenase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001352375
UniProtKB:P14679

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

P

Seeded From UniProt

complete

involved_in

GO:0043473

pigmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

P

Seeded From UniProt

complete

involved_in

GO:0033280

response to vitamin D

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

P

Seeded From UniProt

complete

involved_in

GO:0009411

response to UV

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A9G4
ensembl:ENSRNOP00000021971

C

Seeded From UniProt

complete

involved_in

GO:0048538

thymus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

F

Seeded From UniProt

complete

involved_in

GO:0043473

pigmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

F

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

C

Seeded From UniProt

complete

involved_in

GO:0042438

melanin biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

P

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11344
ensembl:ENSMUSP00000004770

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002227

F

Seeded From UniProt

complete

enables

GO:0004503

monophenol monooxygenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.18.1

F

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

PMID:7704033[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006726

eye pigment biosynthetic process

PMID:7704033[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006583

melanin biosynthetic process from tyrosine

PMID:7704033[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005798

Golgi-associated vesicle

PMID:10823941[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:11092760[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042438

melanin biosynthetic process

Reactome:R-HSA-5662702

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033162

melanosome membrane

Reactome:R-HSA-5663050
Reactome:R-HSA-5662692
Reactome:R-HSA-5662662

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0042438

melanin biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0470

P

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0161

C

Seeded From UniProt

complete

part_of

GO:0033162

melanosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0160

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Abdel-Malek, Z et al. (1993) Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes. J. Cell. Sci. 106 ( Pt 4) 1323-31 PubMed GONUTS page
  2. ↑ 2.0 2.1 Palmer, LG & Civan, MM (1975) Intracellular distribution of free potassium in Chironomus salivary glands. Science 188 1321-2 PubMed GONUTS page
  3. ↑ Jantakee, K & Tragoolpua, Y (2015) Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals. Biol. Res. 48 4 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Petris, MJ et al. (2000) The Menkes copper transporter is required for the activation of tyrosinase. Hum. Mol. Genet. 9 2845-51 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Fukai, K et al. (1995) Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism. Nat. Genet. 9 92-5 PubMed GONUTS page
  7. ↑ Halaban, R et al. (2000) Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism. Proc. Natl. Acad. Sci. U.S.A. 97 5889-94 PubMed GONUTS page
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