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PMID:25633964
| Citation |
O'Reilly, RC, Soundar, S, Tonb, D, Bolling, L, Yoo, E, Nadal, T, Grindle, C, Field, E and He, Z' (2015) The Role of Gastric Pepsin in the Inflammatory Cascade of Pediatric Otitis Media. JAMA Otolaryngol Head Neck Surg ' |
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| Abstract |
Otitis media is characterized as an ongoing inflammation with accumulation of an effusion in the middle ear cleft. The molecular mechanisms underlying the pathogenesis, particularly the inflammatory response, remain largely unknown. We hypothesize that aspiration of gastric contents into the nasopharynx may be responsible for the initiation of the inflammatory process or aggravate a preexisting condition. |
| Links |
PubMed Online version:10.1001/jamaoto.2014.3581 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004194: pepsin A activity |
ECO:0000314: |
F |
Causes extraesophageal reflux and may be involved in middle ear inflammatory process |
complete | ||||
Notes
See also
References
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