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HUMAN:TOPK
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PBK (synonyms: TOPK) | |
| Protein Name(s) | Lymphokine-activated killer T-cell-originated protein kinase
Cancer/testis antigen 84 CT84 MAPKK-like protein kinase Nori-3 PDZ-binding kinase Spermatogenesis-related protein kinase SPK T-LAK cell-originated protein kinase | |
| External Links | ||
| UniProt | Q96KB5 | |
| EMBL | AB027249 AB027250 AF189722 AF237709 AK027291 AK301836 AC104997 CH471080 CH471080 BC015191 | |
| CCDS | CCDS6063.1 CCDS64858.1 | |
| RefSeq | NP_001265874.1 NP_060962.2 XP_006716431.1 | |
| UniGene | Hs.104741 | |
| ProteinModelPortal | Q96KB5 | |
| SMR | Q96KB5 | |
| BioGrid | 120971 | |
| IntAct | Q96KB5 | |
| MINT | MINT-130347 | |
| STRING | 9606.ENSP00000301905 | |
| BindingDB | Q96KB5 | |
| ChEMBL | CHEMBL4896 | |
| GuidetoPHARMACOLOGY | 2140 | |
| PhosphoSite | Q96KB5 | |
| DMDM | 83305809 | |
| MaxQB | Q96KB5 | |
| PaxDb | Q96KB5 | |
| PeptideAtlas | Q96KB5 | |
| PRIDE | Q96KB5 | |
| DNASU | 55872 | |
| Ensembl | ENST00000301905 ENST00000522944 | |
| GeneID | 55872 | |
| KEGG | hsa:55872 | |
| UCSC | uc003xgi.3 uc011lap.2 | |
| CTD | 55872 | |
| GeneCards | GC08M027724 | |
| HGNC | HGNC:18282 | |
| HPA | HPA005753 | |
| MIM | 611210 | |
| neXtProt | NX_Q96KB5 | |
| PharmGKB | PA134925802 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00720000108839 | |
| HOGENOM | HOG000294208 | |
| HOVERGEN | HBG056011 | |
| InParanoid | Q96KB5 | |
| KO | K08865 | |
| OMA | ELFYLCT | |
| OrthoDB | EOG7S4X6F | |
| PhylomeDB | Q96KB5 | |
| TreeFam | TF329763 | |
| SignaLink | Q96KB5 | |
| ChiTaRS | PBK | |
| GeneWiki | PBK_(gene) | |
| GenomeRNAi | 55872 | |
| NextBio | 35475910 | |
| PRO | PR:Q96KB5 | |
| Proteomes | UP000005640 | |
| Bgee | Q96KB5 | |
| CleanEx | HS_PBK | |
| ExpressionAtlas | Q96KB5 | |
| Genevestigator | Q96KB5 | |
| GO | GO:0005524 GO:0004674 GO:0034644 GO:0007067 GO:0050728 GO:0032435 GO:0001933 GO:0032873 | |
| InterPro | IPR011009 IPR000719 IPR008271 | |
| Pfam | PF00069 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
ECO:0000314 |
P |
Figures 4, 5, 6, |
complete | |||||
| GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
F |
Figure 4 |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 6 |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034644 |
cellular response to UV |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032873 |
negative regulation of stress-activated MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032435 |
negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9JJ78 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Rizkallah, R et al. (2015) Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Oncotarget 6 1446-61 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, S et al. (2000) Characterization of PDZ-binding kinase, a mitotic kinase. Proc. Natl. Acad. Sci. U.S.A. 97 5167-72 PubMed GONUTS page
n
- GO:0001933 ! negative regulation of protein phosphorylation
- GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0032873 ! negative regulation of stress-activated MAPK cascade
- GO:0050728 ! negative regulation of inflammatory response
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
p
