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HUMAN:RENI

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) REN
Protein Name(s) Renin

Angiotensinogenase

External Links
UniProt P00797
EMBL L00073
L00064
L00065
L00066
L00067
L00068
L00069
L00070
L00071
L00072
M26901
M26899
M26900
M10152
M10030
M10128
M10150
M10151
AY436324
CR536498
EU332871
AL592114
AL592146
AL592146
AL592114
BC033474
BC047752
M15410
M26440
M13253
CCDS CCDS30981.1
PIR A21454
RefSeq NP_000528.1
UniGene Hs.3210
PDB 1BBS
1BIL
1BIM
1HRN
1RNE
2BKS
2BKT
2FS4
2G1N
2G1O
2G1R
2G1S
2G1Y
2G20
2G21
2G22
2G24
2G26
2G27
2I4Q
2IKO
2IKU
2IL2
2REN
2V0Z
2V10
2V11
2V12
2V13
2V16
2X0B
3D91
3G6Z
3G70
3G72
3GW5
3K1W
3KM4
3O9L
3OAD
3OAG
3OOT
3OQF
3OQK
3OWN
3Q3T
3Q4B
3Q5H
3SFC
3VCM
3VSW
3VSX
3VUC
3VYD
3VYE
3VYF
4AMT
4GJ5
4GJ6
4GJ7
4GJ8
4GJ9
4GJA
4GJB
4GJC
4GJD
4PYV
4Q1N
PDBsum 1BBS
1BIL
1BIM
1HRN
1RNE
2BKS
2BKT
2FS4
2G1N
2G1O
2G1R
2G1S
2G1Y
2G20
2G21
2G22
2G24
2G26
2G27
2I4Q
2IKO
2IKU
2IL2
2REN
2V0Z
2V10
2V11
2V12
2V13
2V16
2X0B
3D91
3G6Z
3G70
3G72
3GW5
3K1W
3KM4
3O9L
3OAD
3OAG
3OOT
3OQF
3OQK
3OWN
3Q3T
3Q4B
3Q5H
3SFC
3VCM
3VSW
3VSX
3VUC
3VYD
3VYE
3VYF
4AMT
4GJ5
4GJ6
4GJ7
4GJ8
4GJ9
4GJA
4GJB
4GJC
4GJD
4PYV
4Q1N
ProteinModelPortal P00797
SMR P00797
BioGrid 111904
DIP DIP-59219N
IntAct P00797
MINT MINT-1381167
STRING 9606.ENSP00000272190
BindingDB P00797
ChEMBL CHEMBL286
DrugBank DB01258
DB00212
GuidetoPHARMACOLOGY 2413
MEROPS A01.007
PhosphoSite P00797
UniCarbKB P00797
DMDM 132326
PaxDb P00797
PRIDE P00797
DNASU 5972
Ensembl ENST00000272190
GeneID 5972
KEGG hsa:5972
UCSC uc001haq.2
CTD 5972
GeneCards GC01M204123
GeneReviews REN
HGNC HGNC:9958
HPA CAB025903
HPA005131
MIM 179820
267430
613092
neXtProt NX_P00797
Orphanet 217330
97369
PharmGKB PA297
eggNOG NOG248684
GeneTree ENSGT00760000118929
HOGENOM HOG000197681
HOVERGEN HBG000482
InParanoid P00797
KO K01380
OMA NFIARYY
OrthoDB EOG7HQN88
PhylomeDB P00797
TreeFam TF314990
Reactome REACT_147707
EvolutionaryTrace P00797
GeneWiki Renin
GenomeRNAi 5972
NextBio 23249
PMAP-CutDB P00797
PRO PR:P00797
Proteomes UP000005640
Bgee P00797
CleanEx HS_REN
ExpressionAtlas P00797
Genevestigator P00797
GO GO:0005737
GO:0005576
GO:0005615
GO:0005886
GO:0004190
GO:0008233
GO:0005102
GO:0002003
GO:0050435
GO:0048469
GO:0044267
GO:0035690
GO:0042756
GO:0009755
GO:0001822
GO:0008584
GO:0001823
GO:0006508
GO:0008217
GO:0043408
GO:0002018
GO:0051591
GO:0070305
GO:0035902
GO:0032496
Gene3D 2.40.70.10
InterPro IPR001461
IPR001969
IPR012848
IPR021109
PANTHER PTHR13683
Pfam PF07966
PF00026
PRINTS PR00792
SUPFAM SSF50630
PROSITE PS00141

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004195

renin activity

PMID:25635129[1]

ECO:0000314

F

Aids in homeostasis

complete
CACAO 10582

part_of

GO:0045177

apical part of cell

PMID:26322847[2]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0002305)
  • part_of:(UBERON:0001232)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:26322847[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001969)

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:16116425[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:12045255[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O75787

F

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002003

angiotensin maturation

PMID:12045255[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000190503
CGD:CAL0000194661
CGD:CAL0000196689
CGD:CAL0000201140
MGI:MGI:1346542
PANTHER:PTN000342793
RGD:621511
SGD:S000002551
TAIR:locus:2008940
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P41748
UniProtKB:P43094
UniProtKB:P56817
UniProtKB:Q59VH7
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
WB:WBGene00000217

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97898
MGI:MGI:97899
PANTHER:PTN002671446
RGD:3554
UniProtKB:P00797

C

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000196689
MGI:MGI:107361
MGI:MGI:1915935
MGI:MGI:88562
PANTHER:PTN000342793
PomBase:SPCC1795.09
RGD:2446
SGD:S000001277
SGD:S000002551
SGD:S000004110
SGD:S000004111
TAIR:locus:2145954
UniProtKB:P00797
UniProtKB:P0CY27
UniProtKB:P14091
UniProtKB:P20142
UniProtKB:P56817
UniProtKB:Q4WNV0
UniProtKB:Q5AC08
UniProtKB:Q8I6Z5
UniProtKB:Q9LTW4
UniProtKB:Q9Y5Z0

F

Seeded From UniProt

complete

involved_in

GO:0002003

angiotensin maturation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97898
PANTHER:PTN000342885
RGD:3554
UniProtKB:P00797

P

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

PMID:12045255[4]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048469

cell maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0042756

drinking behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0008584

male gonad development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

C

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

F

Seeded From UniProt

complete

involved_in

GO:0002018

renin-angiotensin regulation of aldosterone production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0002016

regulation of blood volume by renin-angiotensin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0002003

angiotensin maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0001823

mesonephros development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06281
ensembl:ENSMUSP00000092135

P

Seeded From UniProt

complete

involved_in

GO:0070305

response to cGMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0051591

response to cAMP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0050435

amyloid-beta metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0035902

response to immobilization stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

C

Seeded From UniProt

complete

enables

GO:0005159

insulin-like growth factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

F

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

F

Seeded From UniProt

complete

involved_in

GO:0002003

angiotensin maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08424
ensembl:ENSRNOP00000003951

P

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001461
InterPro:IPR001969
InterPro:IPR012848

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

PMID:7584914[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2065357
Reactome:R-HSA-2022403

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-2022412

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002003

angiotensin maturation

Reactome:R-HSA-2065357
Reactome:R-HSA-2022412
Reactome:R-HSA-2022403

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0064

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Cao, W et al. (2015) A Salt-Induced Reno-Cerebral Reflex Activates Renin-Angiotensin Systems and Promotes CKD Progression. J. Am. Soc. Nephrol. 26 1619-33 PubMed GONUTS page
  2. ↑ 2.0 2.1 Marques, FZ et al. (2015) Signatures of miR-181a on the Renal Transcriptome and Blood Pressure. Mol. Med. 21 739-748 PubMed GONUTS page
  3. ↑ Gribouval, O et al. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat. Genet. 37 964-8 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Nguyen, G et al. (2002) Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109 1417-27 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Tamura, K et al. (1995) Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body. Hypertens. Res. 18 7-18 PubMed GONUTS page
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